Navigation Links
Study suggests link between scleroderma, cancer in certain patients
Date:7/8/2010

Patients with a certain type of scleroderma may get cancer and scleroderma simultaneously, Johns Hopkins researchers have found, suggesting that in some diseases, autoimmunity and cancer may be linked.

These findings could lead researchers closer to discovering what causes scleroderma, an incurable autoimmune disease that causes scar tissue to develop in the skin and in major organ systems, and to pinning down why some with scleroderma appear to be at increased risk of cancer. The insights add to the growing body of evidence linking some autoimmune disorders with cancer.

"Our research adds more to the discussion about whether cancer and autoimmune diseases are related and whether cancer may be a trigger for scleroderma," says Ami A. Shah, M.D., M.H.S., an assistant professor of medicine in the division of rheumatology at the Johns Hopkins University School of Medicine and the study's lead author.

The small study, which appears online in the journal Arthritis & Rheumatism, looked at blood and tumor samples from 23 patients with both scleroderma and cancer who were treated at the Johns Hopkins Scleroderma Center. Ten percent of the patients treated at the scleroderma center have cancer as well as the autoimmune disease.

The researchers looked for specific immune markers in each patient, determining which type of antibodies the patients made. Those with antibodies called anti-RNA polymerase I/III had the most closely related onset of cancer and scleroderma, they found. Those patients got both diseases within two years of one another. Similar results were also found in another subset of patients those who tested positive for none of the known autoimmune antibodies. Researchers suspect there are immune markers in their blood that have yet to be discovered.

The reasons for the apparent link between scleroderma and cancer are not understood, Shah says. And it is unknown whether cancer could be causing scleroderma or if scleroderma could be causing cancer.

Most often, Shah says, the patients developed cancer first and then scleroderma soon after. She says one theory, as yet unproven, is that as the body generates an immune response to fight a tumor, the immune response could trigger the development of scleroderma. It is also possible, she says, that the immune response could successfully defeat a developing tumor but still result in scleroderma.

Another possibility could be that organ damage from scleroderma could predispose patients to cancer. Or it could be that the use of immune-suppressing drugs to treat scleroderma could lead to cancer.

She says that some reports in the medical literature have shown that in cases of concurrent cancer and scleroderma, treating the cancer halted the progression of the autoimmune disorder.

Several other autoimmune disorders also appear to have potential links to cancer, Shah says. This research could have implications for those diseases as well.

Many questions remain and more research is needed, says Livia Casciola-Rosen, Ph.D., an associate professor of medicine in the division of rheumatology at Johns Hopkins' medical school and one of the study's principal investigators. "Are particular antibodies in scleroderma associated with increased risk of cancer? Maybe we need to look," she says. "And if you develop both at the same time, does treatment of one affect the outcome of the other?

"This research," she says, "is really just the beginning."


'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... , ... December 07, 2016 , ... A quote from ... outpouring of comments on social media that offer a rare glimpse into the mind ... ADHD authority and New York Times bestselling author, has described people with ADHD as ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Cliff Hart ... in South Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, and Farmington Hills, is ... for a brain tumor. , Jason Bauer and his family are longtime members ...
(Date:12/7/2016)... ... ... A. Kevin Spann Insurance, a New York-based firm offering insurance and financial consultation ... drive to raise funds that will benefit the Marine Corps League. , The Marine ... Corpsmen. Working closely with the MCL, the A. Kevin Spann team plans to generate ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... Delete® - ... in Time For The Holiday Party Season. Save Up To 33% Off Botox® and ... Salon is providing the Phoenix Valley with Delightful Deals on Botox® and ...
(Date:12/7/2016)... ... 2016 , ... Gensuite is honored to be selected as ... Product Launch category. Gensuite’s entry on their EZ Scan feature detailed the tool’s ... Training Group is a professional event and training provider based in the United ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... 7, 2016  Organovo Holdings, Inc. (NASDAQ: ... focused on delivering scientific and medical breakthroughs using ... and Chief Executive Officer Keith Murphy ... December 14, 2016 at 1:00 p.m. Eastern Time ... yet familiar with the Company, an informational video ...
(Date:12/7/2016)... Today, Stock-Callers.com presents four Biotech equities for review, ... Pharmaceuticals Inc. (NASDAQ: ANTH ), ProNAi Therapeutics Inc. ... AVXS ). From its peak in July 2015, the ... level equal to what it saw at the start of ... year, it has still out-performed other market sectors, beating the ...
(Date:12/7/2016)... 7, 2016  Lannett Company, Inc. (NYSE: LCI ) ... Markets 2016 Prescription for Success Healthcare Conference on December 14, 2016 ... New York City . In addition, the ... Guggenheim Securities 4 th Annual Boston Healthcare Conference taking place ... ...
Breaking Medicine Technology: