Navigation Links
Study suggests link between scleroderma, cancer in certain patients
Date:7/8/2010

Patients with a certain type of scleroderma may get cancer and scleroderma simultaneously, Johns Hopkins researchers have found, suggesting that in some diseases, autoimmunity and cancer may be linked.

These findings could lead researchers closer to discovering what causes scleroderma, an incurable autoimmune disease that causes scar tissue to develop in the skin and in major organ systems, and to pinning down why some with scleroderma appear to be at increased risk of cancer. The insights add to the growing body of evidence linking some autoimmune disorders with cancer.

"Our research adds more to the discussion about whether cancer and autoimmune diseases are related and whether cancer may be a trigger for scleroderma," says Ami A. Shah, M.D., M.H.S., an assistant professor of medicine in the division of rheumatology at the Johns Hopkins University School of Medicine and the study's lead author.

The small study, which appears online in the journal Arthritis & Rheumatism, looked at blood and tumor samples from 23 patients with both scleroderma and cancer who were treated at the Johns Hopkins Scleroderma Center. Ten percent of the patients treated at the scleroderma center have cancer as well as the autoimmune disease.

The researchers looked for specific immune markers in each patient, determining which type of antibodies the patients made. Those with antibodies called anti-RNA polymerase I/III had the most closely related onset of cancer and scleroderma, they found. Those patients got both diseases within two years of one another. Similar results were also found in another subset of patients those who tested positive for none of the known autoimmune antibodies. Researchers suspect there are immune markers in their blood that have yet to be discovered.

The reasons for the apparent link between scleroderma and cancer are not understood, Shah says. And it is unknown whether cancer could be causing scleroderma or if scleroderma could be causing cancer.

Most often, Shah says, the patients developed cancer first and then scleroderma soon after. She says one theory, as yet unproven, is that as the body generates an immune response to fight a tumor, the immune response could trigger the development of scleroderma. It is also possible, she says, that the immune response could successfully defeat a developing tumor but still result in scleroderma.

Another possibility could be that organ damage from scleroderma could predispose patients to cancer. Or it could be that the use of immune-suppressing drugs to treat scleroderma could lead to cancer.

She says that some reports in the medical literature have shown that in cases of concurrent cancer and scleroderma, treating the cancer halted the progression of the autoimmune disorder.

Several other autoimmune disorders also appear to have potential links to cancer, Shah says. This research could have implications for those diseases as well.

Many questions remain and more research is needed, says Livia Casciola-Rosen, Ph.D., an associate professor of medicine in the division of rheumatology at Johns Hopkins' medical school and one of the study's principal investigators. "Are particular antibodies in scleroderma associated with increased risk of cancer? Maybe we need to look," she says. "And if you develop both at the same time, does treatment of one affect the outcome of the other?

"This research," she says, "is really just the beginning."


'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... announces the European launch of their new low volume, high throughput ... Cambridge, U.K on October 4th. The new ... unprecedented speed and sensitivity while using far less sample volume through ... ... ...
Breaking Medicine Technology: