Navigation Links
Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target
Date:4/14/2011

ctures of DNA before and after being cut by FEN1.

Earlier crystal structures suggested that FEN1 first grabs onto the flap of the 5' single stranded DNA, slides down to the joint where DNA is duplicated, and cuts and patches the primer there. But the new study found that, in fact, FEN1 binds, bends, frays, and then cuts the DNA.

"It binds duplex DNA, bends it into a single-stranded DNA right at the flap, flips out two base pairs, and cuts between them," said Tainer. "This gives FEN1 very precise controla sophistication we had not expected."

Clues to cancer control

Researchers know that mutations in FEN1 can predispose humans to cancer growth because errors in flap removal can create unstable DNA that promotes cell growth and division. And studies in mice have shown that when one of two inherited FEN1 genes are knocked out, the mice are predisposed to cancer development if their DNA is damaged.

While other DNA repair systems can help compensate for FEN1 mistakes, or for missing FEN1 activity, "you need a lot of FEN1 for DNA repair and replication to work properly," Tainer said.

This suggests that, in tumors already missing one set of repair proteins, selectively inhibiting the function of FEN1 in rapidly replicating cells may prove to be an effective anti-cancer therapy. "The Achilles heel of cancer cells is defective DNA repair pathways," said Tainer, "because that makes them more sensitive to traditional therapies, such as chemotherapy and radiation. If cancer can't repair the damage these therapies do to tumors, they will die."

This is the paradox of DNA repair: while a defect in DNA repair can cause cancer, knocking out a number of backup repair systems may make tumors vulnerable to anti-cancer therapies.

"My hope is that our finding of how FEN1 works mechanistically might provide a foundation for a next-generation cancer drug," said Tainer. "We need to cut as many lifelines as pos
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... Downers Grove, IL (PRWEB) July 14, 2014 ... and online marketing company for mental health professionals, ... Professional Counselors Association of North Carolina (LPCANC). ... extend their online marketing solutions to LPCANC members, ... the past 7 years, we have been dedicated ...
(Date:7/14/2014)... Spine Team Texas continues ... diagnosis to treatment and recovery. Currently all physical therapists ... or training for certification in The McKenzie Method. Two ... the extensive program. , “We require certification of our ... in better outcomes for spine pain patients,” said Mark ...
(Date:7/14/2014)... New research and analysis from the national ... examines toxic ingredients in tampons, a product used ... chemicals that may be found in the product’s absorptive ... put women’s health at risk. , According to ... , the potential impact of toxic chemical exposure from ...
(Date:7/13/2014)... Save the Date for the 2014 Art & ... , BOXWOODS & BowTies “A Modern Twist on Southern Traditions” ... Women’s Board of Wolfson Children’s Hospital will host its ... their ongoing commitment to raising funds for the advancement of ... The 2014 Art & Antiques Show is a three-day show ...
(Date:7/13/2014)... 14, 2014 The special two-day sale starts ... Sublime Beauty®. Use coupon code 20SCRUB at the webstore checkout. ... who tries the Fresh Citrus Scrub falls in love with ... is a perfect little cleanser for face, but can also ... beads that help to exfoliate with pleasure, clean pores and ...
Breaking Medicine News(10 mins):Health News:TherapySites Partners With the Licensed Professional Counselors Association of North Carolina to Make Online Marketing Available to All Therapists 2Health News:Spine Team Texas’ Physical Therapists Complete The McKenzie Method Training and Certification 2Health News:Spine Team Texas’ Physical Therapists Complete The McKenzie Method Training and Certification 3Health News:New Patent Analysis Shows Toxic Risk From Tampons 2Health News:New Patent Analysis Shows Toxic Risk From Tampons 3Health News:New Patent Analysis Shows Toxic Risk From Tampons 4Health News:New Patent Analysis Shows Toxic Risk From Tampons 5Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 2Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 3Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 4Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 5Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 6Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 7Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 8Health News:Save the Date for the 2014 Art & Antiques Show benefiting Wolfson Children's Hospital in Jacksonville, FL 9Health News:Discover the Favorite Sublime Beauty® Citrus Scrub: Special "Two-Day Only" Sale 2
... conducted by Professor William Ledger, a fertility expert at ... of producing //a baby through in-vitro fertilisation and the ... study states that the benefits of providing free fertility ... to the government. ,He along with a ...
... is a bacteria resistant to certain antibiotics. This bacteria ... systems, especially in hospitals and nursing homes and is ... like the Netherlands, Sweden, and Norway, where MRSA has ... now facing an increase in incidence with the rates ...
... of infecting 400 Libyan children with AIDS, five Bulgarian Nurses ... //in the Court of Appellations in Tripoli. ... hospital aids made the outbreak possible since all the instruments ... that outbreak was made by them knowingly. ,Re-assessment ...
... seeking various opinions on the issue of doctors being allowed ... a ban. , In its new draft guidance, ... them that the relationship would usually be considered inappropriate. ... the guidelines acknowledge that social circumstances may demand ...
... of Medicine and colleagues finds it’s better to inform ... dizzy feel of nausea previously. ... to adversity – both subjectively and physiologically,’ said lead ... can benefit people greatly.’ ,The study, designed ...
... found in cannabis, also known as hashish or marijuana, ... it on rats //. ,Yehoshua Maor, a ... created a synthetic version of a minor cannabis constituent ... lowering blood pressure, reported science portal The News Medical. ...
Cached Medicine News:Health News:Free IVF Treatment Could Prove Beneficial to the Society And Its Economy 2Health News:Super-bug MRSA Getting Fitter And Out of Control 2Health News:Precautious Measure Help Tolerate Nausea In Patients 2Health News:Precautious Measure Help Tolerate Nausea In Patients 3
(Date:7/10/2014)... DIEGO , July 10, 2014  RESMED INC. (NYSE: ... its fourth quarter and fiscal year ended June 30, 2014 ... Stock Exchange market close. A press release with ResMed,s results ... the company will host a webcast to discuss operating results ... to begin at 1:30 p.m. US Pacific Time and the ...
(Date:7/10/2014)... 2014  BC Technical, the largest nationwide, non-OEM provider ... Inc., a leading provider of Siemens Nuclear Medicine and ... naming BC Technical as the authorized provider of service ... and BC Technical announced today that the two companies ... as the service and systems provider for MiE,s camera ...
(Date:7/10/2014)... Ariz. , July 10, 2014   Ventana ...  Group, today announced it has entered into an agreement ... which operates as EMD Serono in the ... , to collaborate with Merck KGaA,s biopharmaceutical division on ... for an undisclosed target using Ventana,s proprietary diagnostic assays. ...
Breaking Medicine Technology:ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... WaferGen Biosystems, Inc. (OTC Bulletin Board: WGBS ... and the Integrated BioBank of Luxembourg (IBBL) today announced ... expand the use of the WaferGen SmartChip Real-Time PCR ... The agreement includes: The purchase ...
... BUDAPEST, HUNGARY, Dec. 16, 2010 Watson Pharmaceuticals, Inc. ... Plc ("Richter") today announced that Watson,s subsidiary, Watson Laboratories, ... PregLem, S.A., ("Preglem") the wholly owned subsidiary of Richter, ... U.S. and Canada.  In European studies, Esmya™ has been ...
Cached Medicine Technology:WaferGen and Integrated BioBank of Luxembourg (IBBL) Sign Strategic Agreement for Molecular Diagnostic Research Collaboration and Purchase of SmartChip System 2WaferGen and Integrated BioBank of Luxembourg (IBBL) Sign Strategic Agreement for Molecular Diagnostic Research Collaboration and Purchase of SmartChip System 3WaferGen and Integrated BioBank of Luxembourg (IBBL) Sign Strategic Agreement for Molecular Diagnostic Research Collaboration and Purchase of SmartChip System 4WaferGen and Integrated BioBank of Luxembourg (IBBL) Sign Strategic Agreement for Molecular Diagnostic Research Collaboration and Purchase of SmartChip System 5Watson and Richter Announce Exclusive License Agreement for Esmya™ 2Watson and Richter Announce Exclusive License Agreement for Esmya™ 3Watson and Richter Announce Exclusive License Agreement for Esmya™ 4Watson and Richter Announce Exclusive License Agreement for Esmya™ 5
... Workstations provide comprehensive neurological monitoring in ... unit to accurately access your patients ... 15 years experience, and a long ... neurological monitoring systems have a proven ...
Vikingselect™ Intra-Operative Monitoring (IOM)....
The Nicolet Bravo™ is a Multi-application system that can configure to meet the needs of neurophysiology department....
... system especially designed for surgical monitoring and ... channels and is equipped with two headboxes ... can be independently configured as either a ... Endeavor amplifiers are based on the Firewire ...
Medicine Products: