Navigation Links
Study suggests brain tumors need treatment with multiple 'targeted' drugs
Date:9/13/2007

eive signals from the cells' environment. Many of the signals are chemical "growth factors" directing the cell to divide and grow. Signals received by the RTKs are transmitted to the cell's nucleus via a pathway called PI3K, which often behaves abnormally in cancer cells.

At least 54 RTKs have been identified, and some, such as epidermal growth factor receptor (EGFR) have been implicated in glioblastomas. However, drugs that block EGFR have had limited success in delaying the progression of these and other virulent tumors. "Typically one elicits a positive initial response, but rarely durable cures," said DePinho, who is also a professor of medicine at Harvard Medical School. "Overall, the record of receptor tyrosine kinases inhibitors in these brain tumors has been somewhat disappointing."

Perhaps the problem was that other kinase pathways were also sending abnormal growth signals, acting as a redundant or backup source of growth simulation. "No one had looked to see how many receptor tyrosine kinases are activated at the same time in these cells," said Stommel.

The researchers tested 20 glioblastoma cell lines using an antibody array technique that measured the activation of 45 different RTKs at one time. In 19 of the 20 cell lines, three or more RTKs were activated at the same time, sending abnormal growth signals in triplicate to the nucleus. Moving from cell lines to fresh cells, the researchers saw the same multiple-RTK activity when they studied tumor samples from newly diagnosed patients.

The kinase inhibitor imatinib (Gleevec) had little effect on the errant signaling pathways when applied to the brain tumor cells. But when imatinib was given in combination with two other kinase inhibitors, erlotinib (Tarceva) and SU11274, traffic in the PI3K signaling pathway was eliminated, and the cancer cells died.

The study's findings "provide a rational explanation for the feeble clinical responses" when RTK inhibitors are
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Rural Canadians travel far for specialists: study
2. A new study surpasses Gene Therapy Hurdle
3. Tomato Sauce reduces Cancer Risk- Study
4. A question on study of Adult Stem Cell
5. Study on obesity and heart failure
6. National Lung Study in the process
7. Marijuana gateway theory strengthened by study of twins
8. Old theory of adaptation confirmed by new study
9. Study casts doubt on keyboard ills
10. Gene study links endometriosis, infertility
11. Study reveals how stress can make you sick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post presenting the ... , Purchasing an accidental death and dismemberment rider for ... of rider provides benefits if the insured dies in an ... form of life insurance. , AD&D is not expensive ...
(Date:1/22/2015)... 2015 A study recently published ... journal Medicine & Science in Sports & Exercise ... help reduce gastrointestinal (GI) problems associated with physical ... in the double-blind, placebo-controlled study took 10 grams ...
(Date:1/22/2015)... Weddingshe.com has added many trendy Champagne wedding dresses ... in the past three years. Today, the business announces a ... to the sales manager of the company, this is on ... This point can be reflected on the discounted wedding dresses ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Four years since the ... – which coincided with the marriage of Avasa & Matthew Love ... ROAD, which is scheduled for release through White Swan Records on ... that there is a sacred path available to all of us ...
(Date:1/22/2015)... EBSCO Information Services (EBSCO) and the ... in an effort to further promote visibility and adoption of ... long made AMA journals available via its subscription services, EBSCO ... Network. , Long known as both a subscription ...
Breaking Medicine News(10 mins):Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... of donated skin, causing concerns as Christmas holidays arrive.// ... Sunnybrook health sciences center in Toronto, more skin had flown ... more than 80% of his body. ,Skin, ... caused by fire. It is usually taken within 24 ...
... of 66 cases of measles were reported from across the U.S ... single source. A 17 year old girl, who had travelled to// ... the U.S. The highly contagious infection characterised by typical rashes ... contacts that had interacted with her upon her return to the ...
... are effective, a new review of studies has found. ... as// depression and health-related quality of life, they also ... this analysis was both more inclusive and more conservative ... date that these interventions are helpful,” said psychologist and ...
... other joint, in part because of their intricate system of ... injure the// anterior cruciate ligament (ACL) twice as often as ... Hip Pain, a new report from Harvard Medical School, explains ... weak knees. The report also outlines steps women can take ...
... holidays approached last year, Soraya Kohanzadeh, 30, Muir Beach, ... no hope and expecting to live a shortened life// ... but because her “anti-donor” antibody levels were so high, ... – perhaps ever. However, thanks to a specialized type ...
... of Traditional Chinese Medicine is causing concern to health officials ... in less than a week and has resulted in the ... ,Xinhua News Agency reports that the students who have been ... students were discharged on Wednesday. ,It is expected ...
Cached Medicine News:Health News:Missed Vaccination Caused Largest Measles Outbreak in U.S in 2005 2Health News:Psychological Treatments Improve Outcomes for Back Pain Sufferers 2Health News:Psychological Treatments Improve Outcomes for Back Pain Sufferers 3Health News:Therapy Modulates Highly Sensitized Immune System to Let Mother Give Kidney to Daughter 2Health News:Therapy Modulates Highly Sensitized Immune System to Let Mother Give Kidney to Daughter 3Health News:Therapy Modulates Highly Sensitized Immune System to Let Mother Give Kidney to Daughter 4
(Date:1/23/2015)... BOSTON , January 23, 2015 ... development company, is delighted to announce that the Malcolm ... Miles Congreve (Vice President of Chemistry), Fiona ... Weir (Chief Executive Officer and co-founder) for the seminal ...
(Date:1/22/2015)...  ResMed Inc. (NYSE: RMD ) today announced results ... quarter was $423.0 million, a 10 percent increase compared to ... on a constant currency basis). Net income was $91.2 million, ... December 31, 2013. Diluted earnings per share for the quarter ...
(Date:1/22/2015)... 22, 2015 Increasing sophistication among enterprise buyers of ... purchasing in 2015, says Moravia CMO, ... study by market research firm Common Sense Advisory, 15 ... their translation and localization needs. "From a language industry ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... DIEGO , March 16 ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ANX ) today reported financial results for the fourth quarter and year ended December 31, 2009 . ... , ... ... ...
... Sigma-Aldrich® (Nasdaq: SIAL ) today announced ... Inc., a Berks County, PA. -based provider of ... Animals ( www.aceanimals.com ), a commercial rodent breeder established ... services, and will operate as part of Sigma Advanced ...
Cached Medicine Technology:ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 2ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 3ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 4ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 5ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 6ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 7ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 8ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 9ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 10ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results 11Sigma-Aldrich Further Expands In Vivo Biology Offering by Signing an Agreement to Acquire Ace Animals, Inc. 2Sigma-Aldrich Further Expands In Vivo Biology Offering by Signing an Agreement to Acquire Ace Animals, Inc. 3Sigma-Aldrich Further Expands In Vivo Biology Offering by Signing an Agreement to Acquire Ace Animals, Inc. 4Sigma-Aldrich Further Expands In Vivo Biology Offering by Signing an Agreement to Acquire Ace Animals, Inc. 5Sigma-Aldrich Further Expands In Vivo Biology Offering by Signing an Agreement to Acquire Ace Animals, Inc. 6Sigma-Aldrich Further Expands In Vivo Biology Offering by Signing an Agreement to Acquire Ace Animals, Inc. 7
Red Latex Bardex I.C. Foley 2-Way Catheter (Council Model)...
... The Coude tip design facilitates ... is available in a medium length ... drainage eye. The red latex construction ... catheter is also available in a ...
Used to provide bladder drainage by percutaneous placement of a balloon catheter. Supplied sterile in peel-open packages. Intended for one-time use....
Used to provide bladder drainage by percutaneous placement of a Malecot catheter. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: