Navigation Links
Study suggests antibiotic may prevent dreaded brain fever
Date:2/19/2008

Two researchers from National Brain Research Center (NBRC) suggest that a common antibiotic called minocycline may prevent children from death due to Japanese encephalitis (JE), or commonly known as brain fever. Japanese Encephalitis virus is the causative agent for JE. Although there is no consolidated official figure for JE cases in India, a rough estimate would indicate a few thousands fatalities every year. The team found that minocycline, an USFDA approved drug, often used to treat acne, limits the death by reducing the microglial activation, neuronal death as well as viral replication. Microglia are cells that act as the "cleanup crew" for the Central Nervous System (CNS). They destroy damaged cells by releasing toxins and engulfing them. Should they become activated and release their toxins in the CNS, the toxins will kill the healthy neurons critical for normal function of brain.

Our studies in mice suggest that this antibiotic may be a strong candidate for further consideration as a therapeutic drug in patients with JE said Anirban Basu, PhD, Staff Scientist and senior author of this work from NBRC, Manesar, Haryana. The study titled Minocycline neuroprotects, reduces microglial activation, inhibits caspase-3 induction, and viral replication following Japanese Encephalitis will be published in the future issue of Journal of Neurochemistry (www.blackwell-synergy.com/loi/jnc), a journal of the International Society for Neurochemistry. Previous studies from the same group have shown that following JE there was an increased production of cytokines, proteins that cause inflammation of the brain as well as death of neurons. This study goes a step further to show that minocycline is helpful in reducing the level of cytokines and neuronal death following JE. The major finding in this study is that treatment with minocycline provides a complete protection against experimental JE. Minocyclines neuroprotective action is associated with marked decrease in
'/>"/>

Contact: Melanie Thomson
melanie.thomson@oxon.blackwellpublishing.com
01-865-476-270
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... 28, 2014 PreDiabetes Centers ... treatment, helped employees learn their risk for type ... screening at a local school in partnership with ... initiative. , As the Presenting Sponsor for ... PreDiabetes Centers is co-hosting diabetes-prevention presentations at Austin-area ...
(Date:11/28/2014)... 28, 2014 More than 2,100 ... been filed in a New Jersey litigation that ... Liebhard LLP reports. , A Case List ... Court reflects the filing of 2,160 claims over ... which were voluntarily recalled on July 6, 2012 ...
(Date:11/28/2014)... Patten Pecans, based in Lakeland, Georgia, loves all ... them, they've added a pecan oil to their collection ... they've found this pecan oil from Oliver Farm ... the buttery pecan notes that are in the nuts ... in pecans nuts is found in pecan oil, especially ...
(Date:11/28/2014)... Before that Thanksgiving meal even had time ... Christmas shopping season. Today, people will stand in line for ... biggest retail shopping day of the year. , But ... New Albany dentist Dr. Ronald Receveur is asking the ... and literally brighten a few smiles. , The gifts he ...
(Date:11/28/2014)... Based in Minneapolis, MN, Secura Consultants is a ... to the income and asset protection markets as well ... extend its reach across the nation to bring better ... brought aboard financial service industry veteran, Matt Lee, as ... in specialization. When I decided to focus on the ...
Breaking Medicine News(10 mins):Health News:PreDiabetes Centers Offers Workplace Diabetes Screening at Local School 2Health News:More than 2,100 Stryker Hip Lawsuits Included in New Jersey Litigation after Settlement Announcement, Bernstein Liebhard LLP Reports 2Health News:More than 2,100 Stryker Hip Lawsuits Included in New Jersey Litigation after Settlement Announcement, Bernstein Liebhard LLP Reports 3Health News:Patten Pecans Goes Local with Nutritious Georgia Pecan Oil 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 3Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 4Health News:Matt Lee, CLU, ChFC Joins Secura Consultants as New Brokerage Consultant 2
... Lingering physical effects of cancer a likely cause, finds study, ... fighting cancer wasn,t hard enough, a new Dutch study concludes ... be able to find a job. , The meta-analysis of ... those who,d battled cancer were out of work vs. 15.2 ...
... Hospital of Paris Joins The Global Prevention Network(TM) ... U.S. Preventive Medicine(R), the leader in disease prevention ... American Hospital of Paris to jointly deliver preventive ... serve as a referral Center of Excellence for ...
... of trying to figure out the ,Nanny Tax,CHICAGO, Feb. 17 ... are two things parents never imagined they,d see in ... exciting female political figures having issues due to this type ... That,s why Sittercity.com, America,s largest and most trusted online source ...
... was approved as a routine vaccination for girls aged 11 ... series of shots that protect against human papillomavirus, which is ... a majority of teen girls, parents and young women in ... to a new policy brief released today by the UCLA ...
... Ore. New research at Oregon Health & Science University,s ... HIV in the initial stages of infection before ... a successful approach in limiting the spread of the disease. ... the journal Nature Medicine and will appear in ...
... of the American Recovery and Investment Act of 2009 ... Republican Senator Arlen Specter of Pennsylvania for his leadership ... Institutes of Health (NIH). , "Senator Specter has ... research and to the fight against cancer," said Margaret ...
Cached Medicine News:Health News:One in Three Cancer Survivors on Unemployment Line 2Health News:One in Three Cancer Survivors on Unemployment Line 3Health News:U.S. Preventive Medicine(R), American Hospital of Paris Sign Affiliation Agreement to Deliver Preventive Medicine Services 2Health News:U.S. Preventive Medicine(R), American Hospital of Paris Sign Affiliation Agreement to Deliver Preventive Medicine Services 3Health News:Sittercity.com Makes Nanny Taxes Less Taxing 2Health News:Sittercity.com Makes Nanny Taxes Less Taxing 3Health News:1 in 4 California adolescent girls has had HPV vaccine 2Health News:OHSU vaccine research targets HIV in the slower, early stage of infection 2Health News:American Association for Cancer Research lauds Senator Arlen Specter 2
(Date:11/28/2014)... 28, 2014 Aratana Therapeutics, Inc. (NASDAQ: ... licensing or acquisition, development and commercialization of innovative biopharmaceutical ... announced that it will present at the 26 th ... December 2-3, 2014, at the New York Palace Hotel ... Steven St. Peter , M.D., President and Chief ...
(Date:11/27/2014)... 27, 2014  Javon Bea Mercy Health System ... and staff at Janesville Craig High School and Janesville ... Health System physicians and Janesville ... and the Janesville School District. ... dedicated to providing schools and other organizations with the ...
(Date:11/26/2014)... SAN DIEGO , Nov. 26, 2014  Aethlon ... into a definitive agreement to raise approximately $3.3 million ... is being made by one institutional healthcare focused investor. Each ... one-fifth of a common share purchase warrant. Each whole ... at a price of $0.30 for a period of ...
Breaking Medicine Technology:Aratana Therapeutics to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Mercy Health System, Janesville Police / Fire, provide casualty training to high school faculty 2Mercy Health System, Janesville Police / Fire, provide casualty training to high school faculty 3Aethlon Medical Announces $3.3 Million Equity Investment 2Aethlon Medical Announces $3.3 Million Equity Investment 3
... , RALEIGH, N.C., Nov. 24 Pharmaceutical ... pharmaceutical and biotech industry, today announced the launch of a ... Hospital Marketplace e-course is the newest addition to ... series of e-courses designed to fill the critical need for ...
... , SALT ... City based software company, announces the launch of a new online vision ... with existing in-office therapy methods. , eyeQ was introduced at ... Brad Habermehl believes the eyeQ program adds significant value to ...
Cached Medicine Technology:Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 3Infinite Mind Announces the Launch of a New Online Vision Therapy Program eyeQ 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: