Navigation Links
Study shows younger women with endometrial cancer can safely keep ovaries, avoid early menopause
Date:1/28/2009

In this New Digest:

  • Summary of study being published online January 26, 2009 in the Journal of Clinical Oncology,showing no survival difference between premenopausal women with early-stage endometrial cancer whose ovaries were left intact during cancer surgery compared with those whose ovaries were surgically removed.
  • Quote for attribution from Beth Karlan, MD, American Society of Clinical Oncology gynecologic cancer expert and Director, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology at Cedars-Sinai Medical Center
  • Links to additional information on Cancer.Net, ASCO's patient Web site

Study Summary

In the largest study to date on the safety of ovarian preservation in women aged 45 and younger who were surgically treated for early-stage endometrial cancer, researchers have found that there is no survival benefit associated with surgical removal of the ovaries, compared to women whose ovaries were left intact. Leaving the ovaries in place could spare many women from the side effects of surgery-induced early menopause, such as hot flashes and vaginal dryness, as well as the long-term increased risk of heart disease, osteoporosis and hip fractures.

"Our research suggests that oncologists may no longer need to remove the ovaries during surgery in younger women with early-stage endometrial cancer, which has been the standard approach for many years. Leaving the ovaries intact appears to be a safe option that offers women a range of important short- and long-term health and quality of life benefits," said lead author Jason D. Wright, MD, assistant professor of obstetrics and gynecology in the Division of Gynecologic Oncology at Columbia University College of Physicians & Surgeons.

Surgical removal of the uterus (hysterectomy) is the standard of care for endometrial cancer. During the procedure, surgeons usually remove the ovaries as well, a procedure called oophorectomy. Oophorectomy is usually performed to reduce the risk of cancer spreading to the ovaries and also to lower estrogen levels that may fuel the growth of any remaining endometrial cancer cells. However, studies have shown that these risks are small, and the benefits of oophorectomy have not been established by research.

In this study, Dr. Wright and his colleagues compared five-year survival between 402 women aged 45 and younger who were diagnosed with stage I endometrial cancer (cancer confined to the uterus) whose ovaries were preserved, and 3,269 similar women whose ovaries were removed. All patients had a hysterectomy and were diagnosed between 1988 and 2004. Data were derived from the Surveillance, Epidemiology and End Results (SEER) Database, a collection of cancer data on one-quarter of the U.S. population.

Five-year overall survival was similar between the two groups: Among women who had oophorectomy, 98 percent of those with stage IA disease, 96 percent of those with stage IB disease and 89 percent of those with stage IC disease were still alive. The corresponding figures for women whose ovaries were preserved were 98, 100 and 86 percent, respectively.

The investigators also noted that women were more likely to have had ovarian preservation if they were younger (under age 30), were diagnosed later in the study period, lived in the eastern United States and had a low tumor grade and earlier tumor stage.


'/>"/>

Contact: Kelly Powell
kelly.powell@asco.org
571-483-1365
American Society of Clinical Oncology
Source:Eurekalert

Related medicine news :

1. New study highlights the distress of medical staff
2. Controversial Chemical Lingers Longer in the Body: Study
3. Rochester study raises new questions about controversial plastics chemical
4. C8 Science Panel Completes Uric Acid Study
5. Center for the Study of Traumatic Encephalopathy announces new findings
6. Twin study: Diabetes significantly increases risk for Alzheimers disease and other dementia
7. Penn study identifies how ebola virus avoids the immune system
8. Study: Adding Vimpat significantly reduces partial-onset seizures in adults with epilepsy
9. Roadkill study could speed detection of kidney cancer
10. Top hospitals have 27 percent lower mortality: Annual HealthGrades study
11. New study: Short coverage lapses limit childrens access to health care services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. Raffi Hovsepian, ... included in the 2016 “Guide to America’s Top Plastic Surgeons” for seven consecutive ... of their education, experience, and professional associations. , One the most frequently ...
(Date:12/2/2016)... ... 2016 , ... Universal Medical Systems, Inc. (UMS) the world's ... to offer robotic imaging to veterinary medicine is sponsoring the appearance of Millennia, ... American Association of Equine Practitioners 62nd Annual Convention from December 4-6, 2016 in ...
(Date:12/2/2016)... ... 02, 2016 , ... Clarify Health Solutions, Inc., the leading ... in an initial round of funding. The round was led by experienced investors ... receive far better care through the application of the best technologies from other ...
(Date:11/30/2016)... ... November 30, 2016 , ... The ... been designated as a Cigna Infertility Center of Excellence. The Cigna Center of ... , “It’s an honor to be designated a Cigna Infertility Center of Excellence," ...
(Date:11/30/2016)... CA (PRWEB) , ... November 30, 2016 , ... ... disorder and mental health treatment has announced the opening of a new residential ... treatment for girls with mental health issues such as severe anxiety, depression, bi-polar ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Dec. 2, 2016 Lianluo Smart Limited ... "the Company") which develops, markets and sells medical ... China and international markets, recently ... and Treatment New Progress Forum, co-hosted by the ... Province , Guangdong Provincial People,s Hospital and ...
(Date:12/2/2016)... , Dec. 1, 2016 The concept of ... to be given to this sector has been taking shape ... since then the political aspects and initiatives related to orphan ... and at the level of member states individually. Many member ... 1990s in the space of orphan medicinal products, the result ...
(Date:12/2/2016)... Allergan plc (NYSE: AGN ), a ... previously announced Accelerated Share Repurchase (ASR) Program. Logo - ... ... previously announced, the Company entered into a variable tenor ASR ... repurchase $10 billion of its ordinary shares. Approximately 40.5 million ...
Breaking Medicine Technology: