Navigation Links
Study shows younger women with endometrial cancer can safely keep ovaries, avoid early menopause
Date:1/28/2009

In this New Digest:

  • Summary of study being published online January 26, 2009 in the Journal of Clinical Oncology,showing no survival difference between premenopausal women with early-stage endometrial cancer whose ovaries were left intact during cancer surgery compared with those whose ovaries were surgically removed.
  • Quote for attribution from Beth Karlan, MD, American Society of Clinical Oncology gynecologic cancer expert and Director, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology at Cedars-Sinai Medical Center
  • Links to additional information on Cancer.Net, ASCO's patient Web site

Study Summary

In the largest study to date on the safety of ovarian preservation in women aged 45 and younger who were surgically treated for early-stage endometrial cancer, researchers have found that there is no survival benefit associated with surgical removal of the ovaries, compared to women whose ovaries were left intact. Leaving the ovaries in place could spare many women from the side effects of surgery-induced early menopause, such as hot flashes and vaginal dryness, as well as the long-term increased risk of heart disease, osteoporosis and hip fractures.

"Our research suggests that oncologists may no longer need to remove the ovaries during surgery in younger women with early-stage endometrial cancer, which has been the standard approach for many years. Leaving the ovaries intact appears to be a safe option that offers women a range of important short- and long-term health and quality of life benefits," said lead author Jason D. Wright, MD, assistant professor of obstetrics and gynecology in the Division of Gynecologic Oncology at Columbia University College of Physicians & Surgeons.

Surgical removal of the uterus (hysterectomy) is the standard of care for endometrial cancer. During the procedure, surgeons usually remove the ovaries as well, a procedure called oophorectomy. Oophorectomy is usually performed to reduce the risk of cancer spreading to the ovaries and also to lower estrogen levels that may fuel the growth of any remaining endometrial cancer cells. However, studies have shown that these risks are small, and the benefits of oophorectomy have not been established by research.

In this study, Dr. Wright and his colleagues compared five-year survival between 402 women aged 45 and younger who were diagnosed with stage I endometrial cancer (cancer confined to the uterus) whose ovaries were preserved, and 3,269 similar women whose ovaries were removed. All patients had a hysterectomy and were diagnosed between 1988 and 2004. Data were derived from the Surveillance, Epidemiology and End Results (SEER) Database, a collection of cancer data on one-quarter of the U.S. population.

Five-year overall survival was similar between the two groups: Among women who had oophorectomy, 98 percent of those with stage IA disease, 96 percent of those with stage IB disease and 89 percent of those with stage IC disease were still alive. The corresponding figures for women whose ovaries were preserved were 98, 100 and 86 percent, respectively.

The investigators also noted that women were more likely to have had ovarian preservation if they were younger (under age 30), were diagnosed later in the study period, lived in the eastern United States and had a low tumor grade and earlier tumor stage.


'/>"/>

Contact: Kelly Powell
kelly.powell@asco.org
571-483-1365
American Society of Clinical Oncology
Source:Eurekalert

Related medicine news :

1. New study highlights the distress of medical staff
2. Controversial Chemical Lingers Longer in the Body: Study
3. Rochester study raises new questions about controversial plastics chemical
4. C8 Science Panel Completes Uric Acid Study
5. Center for the Study of Traumatic Encephalopathy announces new findings
6. Twin study: Diabetes significantly increases risk for Alzheimers disease and other dementia
7. Penn study identifies how ebola virus avoids the immune system
8. Study: Adding Vimpat significantly reduces partial-onset seizures in adults with epilepsy
9. Roadkill study could speed detection of kidney cancer
10. Top hospitals have 27 percent lower mortality: Annual HealthGrades study
11. New study: Short coverage lapses limit childrens access to health care services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is ... emergency ambulance transport experience for the millions of people who require these medical ... the taxi industry through the use of technology. Now, SmartEMS has put forth ...
(Date:6/26/2016)... ... ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center for ... Table in Battle Creek, MI, where the rehabilitation facility is located. This annual celebration ... world’s leading providers of cereal and other breakfast foods. Its residents often refer to ...
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... -- Dublin ... the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global market ... its applications in various applications. The report deals with ... main industries: pharmaceutical and biotechnology, food and beverage, and ...
(Date:6/24/2016)... 24, 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... develops, markets and sells medical devices and wearable sleep ... a strategic cooperation agreement with Hongyuan Supply Chain Management ... on June 20, 2016, to develop Dehaier,s new Internet ... agreement, Dehaier will leverage Hongyuan Supply Chain,s sales platform ...
Breaking Medicine Technology: