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Study shows that prostate cancer increases the risk of bone fracture
Date:5/14/2008

As unlikely as it sounds, scientists at the Garvan Institute for Medical Research have shown that there is a link between prostate cancer and a higher risk of bone fracture.

Analysis of data from Garvans Dubbo Osteoporosis Epidemiology Study suggests that men with prostate cancer face a 50% higher risk of fracture, which increases to nearly doubled risk if they are receiving treatment. The results have just been published online in the prestigious international journal Bone.

This is a controversial area which has been under discussion for at least three years, said Garvans Associate Professor Tuan Nguyen, who initiated the study after hearing speculation on the concept. It has taken us about two years to assemble and analyse the data. The results suggest a link between the two diseases, although we still dont understand the mechanisms.

Professor Nguyen and his colleagues have studied 822 men from Dubbo for nearly 20 years. These men were all aged 60 or over in 1989 when the study began. Of the 822 men, 43 subsequently developed prostate cancer. Twenty-two of the men received ADT (androgen deprivation therapy) and 21 did not. Compared to the men without prostate cancer, those with the disease showed a 50% increase in the risk of fracture. For those being treated with ADT, the risk increased approximately twofold.

The results have important implications in practice for several reasons, said Nguyen. First, most of the men who developed prostate cancer started out with a higher BMD (bone mineral density) than average. Second, developing prostate cancer clearly increased their risk of fracture. Third, ADT treatment doubled their risk of fracture.

There are factors at play that we do not yet understand. Obviously the higher BMD of the men with prostate cancer did not protect them against fracture. Exactly what mechanisms are at work are unclear.

Osteoporosis in men often remains untreated, even after a fracture. I
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Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Research Australia
Source:Eurekalert

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