Navigation Links
Study shows that mutations in 1 gene cause many cancers
Date:3/29/2010

ell.

"Mutations in this gene also play a role in developmental disabilities and perhaps in autism, so this mouse model might be useful for studies in those conditions, as well," says co-principal investigator Michael Ostrowski, professor and chair of molecular and cellular biochemistry at Ohio State.

For this study, Leone, Ostrowski and their colleagues developed three strains of genetically identical mice, each of which had one of three specific PTEN mutations found in people with Cowden syndrome. This left each strain with a different version of the PTEN protein. The study showed that each version functioned in a different way, and each influenced cancer development to a different degree.

Mutation 1 disabled the protein altogether and often caused cancer in the animals, while mutation 2 produced a protein that was more active than the normal PTEN protein, and sometimes caused cancer. Mutation 3 altered the protein in ways that should have made it more cancer-causing but also made it more fragile, so less of the protein was present to cause problems. This mutation sometimes didn't cause cancer at all.

Using a database of more than 400 patients with Cowden syndrome, the researchers found that patients with these same mutations have cancer in the corresponding organs as the mice. The mice also showed equivalent gender differences in tumor development, with females developing more thyroid tumors, and males developing more adrenal gland and stomach tumors.

The researchers are now investigating why patients may experience differences in cancer severity even when they have the same mutation.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Casual Sex Doesnt Cause Emotional Damage: Study
2. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
3. Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
4. New study finds possible source of beta cell destruction that leads to Type 1 diabetes
5. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
6. Risk of stroke lower for recent Ontario immigrants: study
7. Definitive study confirms chemo benefit in postmenopausal breast cancer
8. Experimental stem cell treatment arrests acute lung injury in mice, study shows
9. Violence is part of the job say nurses as study shows only 1 in 6 incidents are reported
10. Controversial Autism Study Retracted by Medical Journal
11. Study Reveals Impact Of Health Insurance On Hispanics' Attitudes Towards Healthcare Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... New York, NY (PRWEB) August 20, 2014 ... and architecture firm Perkins Eastman is pleased ... and design services in China and ... internationally recognized Principal Richard Sprow AIA has ... continue his 40-year career in healthcare planning and design ...
(Date:8/20/2014)... deadliest infectious diseases in the world, killing one to ... tuberculosis have long debated its origins. New research shows ... seals and sea lions that brought the disease to ... before Europeans landed on the continent. , The paper, ... New World Human Tuberculosis," was published in Nature ...
(Date:8/20/2014)... through fast-moving waters may be at risk, suggests new ... salmon encounter turbulent, fast-moving water such as rapids ... upstream using a behaviour known as "burst swimming" that ... sockeye passed through extremely fast-moving water, we started to ... spawning grounds," said Nicholas Burnett, a research biologist at ...
(Date:8/20/2014)... New York (PRWEB) August 20, 2014 ... the use of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) ... notes that two U.S. Senators from New York are ... seek a recall of the devices. In a letter ... both Democrats, also implored the agency to seriously consider ...
(Date:8/20/2014)... 20, 2014) Research from Columbia University Medical Center ... stomach cancer growth and that blocking nerve signals using ... for the disease. The study was conducted by the ... Duan Chen, MD, PhD, in Norway and is published ... , "Scientists have long observed that human and mouse ...
Breaking Medicine News(10 mins):Health News:Perkins Eastman Expands Presence in China 2Health News:Perkins Eastman Expands Presence in China 3Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3Health News:Salmon forced to 'sprint' less likely to survive migration 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4Health News:Severing nerves may shrink stomach cancers: Botox injections slow growth of tumors in mice 2
... President , , EAST ... SVNT ) today announced that its Board ... Committee")to oversee the regulatory and pre-launch activities for the ... comprised of independent Board members Lee S. Simon, M.D. ...
... CITY, Nov. 19 UCN, Inc.,(Nasdaq: UCNN ), ... one year renewable agreement for inContact(R) with a leading,healthcare provider ... , This new customer ... Response) solution with call routing between two of the company,s,contact ...
... Stayhealthy, Inc. and EF,Recovery announced today that they ... Fire Rescue Wellness Corporation to bring,revolutionary health and fitness ... "The health and safety of our ... Fire Chief of South Kitsap Fire Rescue. "As our ...
... This month the hit television,show ,Living in Style, ... in Style, is a half-hour news magazine television,series and ... clinically,proven ability to reduce body fat and increase lean ... premier brand of health supplements to,the consumer and utilizes ...
... People in the middle of,separation or divorce ... traditions are shattered; the hope and joy that ... depression. This year,s,economic downturn will add even more ... facing already-difficult financial circumstances. , ...
... LONDON, Nov. 19 With issues around patient comfort ... need to,consider patients, relief and welfare. This is leading ... are being used for a greater,number of patients and ... (Logo: http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO ) , ...
Cached Medicine News:Health News:Savient's Board of Directors Forms a Board Committee to Oversee the Regulatory and Pre-Launch Activities for Pegloticase 2Health News:Savient's Board of Directors Forms a Board Committee to Oversee the Regulatory and Pre-Launch Activities for Pegloticase 3Health News:Savient's Board of Directors Forms a Board Committee to Oversee the Regulatory and Pre-Launch Activities for Pegloticase 4Health News:Savient's Board of Directors Forms a Board Committee to Oversee the Regulatory and Pre-Launch Activities for Pegloticase 5Health News:Savient's Board of Directors Forms a Board Committee to Oversee the Regulatory and Pre-Launch Activities for Pegloticase 6Health News:Savient's Board of Directors Forms a Board Committee to Oversee the Regulatory and Pre-Launch Activities for Pegloticase 7Health News:Savient's Board of Directors Forms a Board Committee to Oversee the Regulatory and Pre-Launch Activities for Pegloticase 8Health News:Leading Healthcare Provider Signs Agreement With UCN for inContact 2Health News:Washington Fire Firefighters Launch First of Its Kind Pilot Program on Health and Fitness 2Health News:Washington Fire Firefighters Launch First of Its Kind Pilot Program on Health and Fitness 3Health News:Clarinol(TM) CLA and Puregels(R) Featured on Hit Television Show 'Living in Style' 2Health News:Clarinol(TM) CLA and Puregels(R) Featured on Hit Television Show 'Living in Style' 3Health News:Holiday Season Amplifies Hurt of Separation and Divorce: Economic Woes Add to Pressure 2Health News:Patient Temperature Management Systems Enjoying Wider Usage 2Health News:Patient Temperature Management Systems Enjoying Wider Usage 3
(Date:8/20/2014)... NEW YORK , Aug. 20, 2014 /PRNewswire/ ... new market research report is available in its ... Electronic Medical Records http://www.reportlinker.com/p0833392/EMR-2014-The-Market-for-Electronic-Medical-Records.html ... fast-changing market for electronic medical records (EMR) for ... a comprehensive report of our findings. Our report ...
(Date:8/20/2014)... August 20, 2014 Glenmark ... Glenmark Pharmaceuticals Limited India (GPL), announces the discovery ... novel clinical development candidate, GBR 1302, a HER2xCD3 ... by the Glenmark Biologics Research Centre located in ... 1302 is based on Glenmark,s innovative BEAT antibody ...
(Date:8/19/2014)... Tenn. , Aug. 19, 2014   ... provide its patient experience technology to ... Under the five-year agreement, CarePoint Health will deploy ... Bayonne Medical Center, Christ Hospital and Hoboken University ... offers a range of software solutions to help ...
Breaking Medicine Technology:EMR 2014: The Market for Electronic Medical Records 2EMR 2014: The Market for Electronic Medical Records 3EMR 2014: The Market for Electronic Medical Records 4EMR 2014: The Market for Electronic Medical Records 5EMR 2014: The Market for Electronic Medical Records 6EMR 2014: The Market for Electronic Medical Records 7EMR 2014: The Market for Electronic Medical Records 8Glenmark Enters Oncology With the Discovery and Initiation of IND Enabling Studies of an Innovative Bispecific Antibody 2Glenmark Enters Oncology With the Discovery and Initiation of IND Enabling Studies of an Innovative Bispecific Antibody 3Lincor Announces Agreement With CarePoint Health For State-Of-The-Art Patient Engagement Technology 2
... 13 As biotechnology,pharmaceutical and medical device companies ... other parts of the world, such as Asia,Eastern ... firms, efforts to do business, according to an ... 2008 Clinical Trials Risk Map provides,those companies a ...
... MORRIS PLAINS, N.J., Aug. 13 Diakron Pharmaceuticals,Inc. ... agreement for a,novel investigational oral anticoagulant drug candidate ... Merck & Co. Inc. Under the,terms of the ... and,if approved, market and distribute the compound worldwide., ...
Cached Medicine Technology:Aon: Complex Insurance Requirements, Risk Management Needs Challenge Firms Conducting Clinical Trials Beyond Own Borders 2Aon: Complex Insurance Requirements, Risk Management Needs Challenge Firms Conducting Clinical Trials Beyond Own Borders 3Aon: Complex Insurance Requirements, Risk Management Needs Challenge Firms Conducting Clinical Trials Beyond Own Borders 4Diakron Licenses Anticoagulant Drug Candidate from Merck & Co., Inc. 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: