Navigation Links
Study shows that major Alzheimer's risk gene causes alterations in shapes of brain protein deposits
Date:7/14/2010

Researchers at Mount Sinai School of Medicine have used a newly discovered class of biomarkers to investigate the possibility that the shape of brain protein deposits is different in people with Alzheimer's who have the highest-risk gene type than in those with the condition who have a neutral risk gene type. The study is being presented July 14 at the 2010 Alzheimer's Association International Conference on Alzheimer's Disease in Honolulu, Hawaii.

Sam Gandy, MD, PhD, the Mount Sinai Professor in Alzheimer's Disease Research, Professor of Neurology and Psychiatry, and Associate Director of the Alzheimer's Disease Research Center at Mount Sinai School of Medicine, led the study. Mount Sinai labs led by Patrick R. Hof, MD, Regenstreif Professor of Neuroscience and Vice-Chair for Translational Neuroscience of the Department of Neuroscience and Dara L. Dickstein, PhD, Assistant Professor, Neuroscience also collaborated on the study.

Apolipoprotein E (APOE) is a gene containing instructions needed to make a protein that helps carry cholesterol in the bloodstream. The APOE gene, which comes in several different forms, is related to increased risk of developing Alzheimer's disease. People with APOE ε4/ε4 gene type have the highest risk of developing the disease and people with APOE ε3/ε3 have a neutral risk. Discovering the important mechanisms underlying how APOE ε4/ε4 increases Alzheimer's risk has been one of the most vexing mysteries facing Alzheimer's researchers for over a decade.

Luminescent conjugated oligothiophenes (LCOs) or luminescent conjugated polymers (LCPs), the newly discovered class of biomarkers, can stick to protein structures in the body and emit colors reflecting the different shapes or forms of the proteins. Among other uses, LCPs/LCOs are currently being employed in test tubes, animal models, and autopsied Alzheimer's brains to study the structure of proteins deposits caused by the dis
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. U of M study finds fast food chains have significantly decreased trans fats in cooking oils
2. Researchers study relationship of oral cancers and periodontal disease
3. Interferon might help asthma patients breathe easier, UT Southwestern study suggests
4. Whisker stimulation prevents strokes in rats, UCI study finds
5. University of Mississippi Medical Center to lead in nationwide NIH-funded Alzheimers study
6. Study shows universal surveillance for MRSA significantly decreased HAIs at PCMH
7. Study finds lifelong doubling in death risk for men who are obese at age 20 years
8. Arsenic shows promise as cancer treatment, Stanford study finds
9. Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
10. Mayo Clinic study finds apathy and depression predict progression from mild cognitive impairment
11. New study suggests tart cherry juice can be a natural solution for insomnia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... 2015 "I recognized the need for ... facilities," said an inventor from Cincinnati, Ohio. "This need ... He developed the Slyde Door to offer an alternative ... facilities. It provides convenient storage space for an evacuation ... available for patients. , This offers added peace ...
(Date:4/18/2015)... Lowcostcarinsuranceprice.com has released a new blog ... auto insurance prices . , Drivers who ... theft may have to pay more for auto insurance ... policies can also offer protection against vehicle theft. ... online on a single website: http://lowcostcarinsuranceprice.com/ . ...
(Date:4/18/2015)... April 18, 2015 In the past ... couple of changes. , "We had to run maintenance ... needed changes," said Jennifer Ramirez, the PR Director. "It ... to say that we are back on track after ... the process of changing phone systems which has not ...
(Date:4/18/2015)... ArcAngel ” was featured on NewsWatch as part of its ... coolest applications on the market for iOS, Android, ... expert, conducted the app review and shared with viewers how ... turbulent world, people may find themselves in dangerous situations where ... move, but some situations can be avoided if there was ...
(Date:4/17/2015)... John Evans, a Gardant affordable assisted ... from 2 p.m. to 3 p.m. on April 24. ... Ct. in Pekin, Illinois, serves older adults of all ... to maintain their independence. , Becky Baker will entertain ... be served during the luau. , For more information, ...
Breaking Medicine News(10 mins):Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:TheBeautyPlace.com Temporary Number Available 2Health News:A Personal Safety Application was Featured on NewsWatch Television 2Health News:John Evans Supportive Living Community Prepares for Party on the Patio 2
... of the service NHS 24 has said that there has been ... working of the system. // This was done after the death ... 24 service. ,The death of a 17-year-old schoolgirl Shomi ... the NHS 24 help line service. They both had called the ...
... act as a model for developing better treatment options to ... // Plat, Mayo Clinic is to lead a team of ... million and the research team would be studying the immune ... found that these infants had their thymus removed and though ...
... eradicate the disease from our country which would be possible ... bacteria and the treatment regimen to be followed for treating ... during the Leprosy day as asked for increasing the awareness ... Lakh of patients in India but the incidence of Leprosy ...
... Court jury has found a South African man guilty of spreading ... // Parenzee had led the women to believe that he had ... also happens top be a mother of two was found HIV ... One of the omen alleged that Parenzee was indifferent to the ...
... In a first ever study conducted on the prevalence of ... and prevention of diabetes has been uncovered. // So ... the results of which cannot be applied to South Asians. ... Hospital for Diabetes and Diabetes Research Centre, an association of ...
... that there are relatively a very small number of dentists who ... patients. // This trend is on the rise and the health ... (NHS) funding for the dental services. ,Many dental graduates ... In 2003 it was only 1% of the dental graduates who ...
Cached Medicine News:Health News:NHS 24: A complete makeover 2Health News:Prevention And Control Of Diabetes Crucial To Indian Population 2Health News:Shortage of dentists in Scotland 2
(Date:4/16/2015)... , April 16, 2015 Mindray ... developer, manufacturer, and marketer of medical devices worldwide, ... Securities and Exchange Commission an Annual Report on Form ... year ended December 31, 2014. An electronic version of ... on Mindray,s investor relations website at  http://ir.mindray.com  or  ...
(Date:4/16/2015)... April 16, 2015  Hologic, Inc. (NASDAQ: ... screening study i published on-line this week ... of the American Cancer Society. The ... of Pittsburgh Medical Center, supports current consensus guidelines ii ... women 30-65 years of age be co-tested with ...
(Date:4/16/2015)... , April 16, 2015  Amgen (NASDAQ: ... first quarter financial results on Tuesday, April 21, 2015, ... announcement will be followed by a conference call with ... the call from Amgen will be Robert A. ... members of Amgen,s senior management team. Live ...
Breaking Medicine Technology:Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Amgen Announces Webcast Of 2015 First Quarter Financial Results 2
... Revenue of $374 million grew 5 percent versus prior year ... the prior year, an increase of 77 percent ... Fiscal year 2011 financial guidance increased:  Constant currency revenue is ... be $2.18 to $2.26 per diluted share Hill-Rom ...
... Covance Inc. (NYSE: CVD ) today ... 31, 2010 of $0.45 per diluted share.  Included in ... costs from the previously-announced fourth quarter restructuring actions, partially ... from favorable income tax resolutions in the quarter. Excluding ...
Cached Medicine Technology:Hill-Rom Reports 77 Percent Growth in First Quarter Earnings Per Share 2Hill-Rom Reports 77 Percent Growth in First Quarter Earnings Per Share 3Hill-Rom Reports 77 Percent Growth in First Quarter Earnings Per Share 4Hill-Rom Reports 77 Percent Growth in First Quarter Earnings Per Share 5Hill-Rom Reports 77 Percent Growth in First Quarter Earnings Per Share 6Hill-Rom Reports 77 Percent Growth in First Quarter Earnings Per Share 7Hill-Rom Reports 77 Percent Growth in First Quarter Earnings Per Share 8Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 2Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 3Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 4Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 5Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 6Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 7Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 8Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 9Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 10Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 11Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 12Covance Reports Fourth Quarter Revenue of $492 Million, GAAP EPS of $0.45, and Pro Forma EPS of $0.56 13
Straight, blunt tips....
Angulated, blunt tips....
Disposable 1 1/4" Tungsten Micro Needle, Ins., Straight...
7 1/2" Bayonet Monopolar Forceps, Ins., Serrated...
Medicine Products: