Navigation Links
Study shows that human hearts generate new cells after birth
Date:1/10/2013

Boston, Mass. Researchers at Boston Children's Hospital have found, for the first time that young humans (infants, children and adolescents) are capable of generating new heart muscle cells. These findings refute the long-held belief that the human heart grows after birth exclusively by enlargement of existing cells, and raise the possibility that scientists could stimulate production of new cells to repair injured hearts.

Findings of the study, "Cardiomyocyte proliferation contributes to post-natal heart growth in young humans," were published in Proceedings of the National Academy of Sciences, Online Early Edition, the week of Jan 7-Jan 11, 2013. The study was led by Bernhard Khn, MD, of the Department of Cardiology at Boston Children's.

Beginning in 2009, Dr. Khn and his team looked at specimens from healthy human hearts, ranging in age from 0 to 59 years. Using several laboratory assays, they documented that cells in these hearts were still dividing after birth, significantly expanding the heart cell population. The cells regenerated at their highest rates during infancy. Regeneration declined after infancy, rose during the adolescent growth spurt, and continued up until around age 20.

The findings offer the strongest evidence to date that proliferation of cardiomyocytes (the cells making up heart muscle) contributes to growth in healthy young human hearts.

"For more than 100 years," Khn says, "people have been debating whether human heart muscle cells are generated after birth or whether they simply grow larger." Khn points out that research in the 1930s and 1940s suggested that cardiomyocyte division may continue after birth, and recent reports about myocardial regeneration in zebrafish and neonatal mice suggest that some young animals regenerate heart muscle by using mechanisms of muscle cell division. Still, for many years, the accepted belief in the scientific community was that human hearts grow after birth only because cells grow larger.

Khn's work challenges the accepted wisdom and offers hope for new treatments for heart failure. Babies and children may be able to increase heart muscle cell proliferation and regenerate damaged parts of their heart muscle. In addition, the study points to new research directions by suggesting that abnormal cardiomyocyte proliferation may be involved in diseases of the heart muscle (cardiomyopathy) that affect young humans, and that cardiomyocyte proliferation could be stimulated in young humans for the treatment of heart failure.

The findings, according to Khn, help to create a "cellular blueprint for how the human heart grows after birth." Using this blueprint, treatment strategies could be developed to treat heart failure in children


'/>"/>

Contact: Rob Graham
rob.graham@childrens.harvard.edu
617-919-3110
Boston Children's Hospital
Source:Eurekalert

Related medicine news :

1. Brown Eyes Beat Blue Ones for Trustworthiness: Study
2. IUD Might Ease Heavy Menstrual Bleeding, Study Suggests
3. Pap Test Could Spot Some Ovarian Cancers, Study Finds
4. Many U.S. Teens at Risk for Suicide Despite Treatment: Study
5. Hispanics leery of health care providers, often avoid cancer screenings, Moffitt study shows
6. Passive smoking increases risk of severe dementia, according to study in China
7. NTU study looks at national attitudes towards homosexuals
8. Brief Life Expectancy Should Rule Out Certain Cancer Screenings: Study
9. High BPA Levels in Kids Linked to Risk for Heart, Kidney Damage: Study
10. Vitamin D Doesnt Improve Knee Arthritis, Study Finds
11. Diet Drinks Tied to Depression Risk in Older Adults: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... met this week to review more than eighty-nine grant submissions all vying ... emerging young scientists in the Parkinson’s field.     , The American Parkinson Disease Association ...
(Date:5/26/2017)... ... May 26, 2017 , ... A new analysis of community health data reveals ... located in the Midwest. With the average cost of healthcare rising and the U.S. ... both the quality and affordability of where they live. An annual 2017 report looked ...
(Date:5/26/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, ... being discussed by President Donald Trump and the rest of the world. Donald Trump ... peace talks in the continuous battle between Israel and Palestine. The world’s eyes are ...
(Date:5/26/2017)... ... 26, 2017 , ... “THE FLINTHILLS FAMILY-Our Journey to the Cross”: the personal journey of Bob ... is the creation of published authors, Bob and Margaret Massey. Bob Massey is small ... "panther quick and leather tough." His love for others is apparent in all of ...
(Date:5/24/2017)... ... 24, 2017 , ... Last month, representatives from Rendina Healthcare ... town officials to celebrate the grand opening of the 87,000 square foot medical ... of its ongoing relationship with RWJBarnabas Health, New Jersey’s largest health system. Two ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)... 25, 2017  In response to the opioid epidemic ... Relief is working with Pfizer to make up to ... cost to community health centers, free and charitable clinics, ... "Pfizer has a long-standing commitment to improving ... patient safety through educational activities," said Caroline Roan ...
(Date:5/18/2017)... May 18, 2017  Two Bayer U.S. Pharmaceutical leaders ... during its recent 28 th Woman of ... event showcases HBA,s longstanding mission of furthering the advancement ... Cindy Powell-Steffen , senior director of ... division, and Libby Howe , a regional business ...
(Date:5/11/2017)... , May 11, 2017  Thornhill Research ... has been awarded an $8,049,024 USD five-year, firm-fixed-priced, ... through the Canadian Commercial Corporation (CCC) ( ... Anesthesia Systems to administer general anesthesia to patients ... "The US Marine Corps have been ...
Breaking Medicine Technology: