Navigation Links
Study shows that high-dose, high-frequency interferon produces no additional benefit
Date:4/15/2008

CAMBRIDGE, MA April 15, 2008 -- Results of a phase IV, open label, head-to-head study of intramuscular AVONEX and high-dose, high-frequency subcutaneous Rebif (interferon beta-1a) provide clinical evidence that the two drugs show similar efficacy over 18 to 30 months of continued therapy in patients with relapsing-remitting multiple sclerosis (RRMS). These data are published in the April 2008 issue of the Current Medical Research and Opinion journal.

The Prospective and Retrospective Long-Term Observational Study of AVONEX and Rebif (PROOF), involved 217 patients with 136 completing a median of 25.9 months of AVONEX 30 mcg once weekly (n=69) and a median of 22.2 months Rebif 44 mcg three times weekly (n=67).

Led by a group of principal investigators including Dr. T. Jock Murray of Division of Neurology, Dalhousie MS Research Unit, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia; Canada; and Dr. Alireza Minagar, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, the study provides further clinical evidence that the dose and frequency of treatment shows no advantage on delivering better efficacy.

Upon evaluation of baseline disability, Expanded Disability Status Scale (EDSS) scores showed no statistically significant differences between the two treatment groups during the prospective portion of the study, with sustained disability progression similar for both: 25.8 percent for AVONEX vs. 26.7 percent for Rebif. Additional key findings include:

  • Relapse rates, MRI endpoints of brain parenchymal fraction, T1 lesion volume, T2 lesion volume, number of new/enlarging T2 lesions and gadolinium enhancing (Gd+) lesion volume and count were also comparable between both groups.

  • In addition, 19 percent of patients taking Rebif tested positive for neutralizing antibodies (NAbs) at end of treatment compared with zero percent taking AVONEX.

Given th
'/>"/>

Contact: Kathleen Vigneault
kathleen.vigneault@mslpr.com
Manning Selvage & Lee
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Marriagelifeinsurance.com has released a new blog post explaining how ... Senior citizens can purchase a joint life insurance policy ... joint policy is cheaper, but will only pay benefits ... insurance can be used to cover important funeral expenses. ... as the application process is simple and straightforward. ...
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new blog post ... for smokers. , Smoking will always have a negative ... the best method to find affordable coverage. Insurance brokerage ... coverage. , Whole life insurance premiums will be ... the coverage is permanent, the initial rates are ...
(Date:10/1/2014)... ATLANTA (PRWEB) October 01, 2014 ... executive networking and relationship-marketing firm, announced today ... Security Executive® and Project of the Year ... decision makers representing organizations in financial services, ... include large-scale technology endeavors that address key ...
(Date:10/1/2014)... DURHAM, N.C. A new genetic finding from Duke ... hostility, anxiety and depression might also be hard-wired to ... diabetes and heart disease. , An estimated 13 percent ... the genetic susceptibility, and knowing this could help them ... healthy diet, exercise and stress management. , "Genetic susceptibility, ...
(Date:10/1/2014)... Innovations announces the upcoming airing of Innovations with ... 20, 2014 at 7:30 a.m. EST/PT via Discovery Channel. ... scenes to learn about Break the Cycle’s comprehensive dating ... help and information Break the Cycle provides to teens ... abuse, how to navigate the legal system, and provides ...
Breaking Medicine News(10 mins):Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Gene interacts with stress and leads to heart disease in some people 2Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2
... ... its new home at the UCSF Mission Bay campus near downtown San Francisco. , ... (Vocus) June 22, 2010 -- UCSF ... new home at the UCSF Mission Bay campus near downtown San Francisco. The gift is ...
... ... Support Initiatives , ... Santa Clara, Calif. (PRWEB) June 22, 2010 -- Aerohive Networks, creators of the ... joined the company as Vice President of Technical Operations. Jiang will report directly to ...
... Physicist David William Townsend will be honoured with the ... for the design, commercial development and clinical implementation of ... medal jointly with his co-inventor, engineer Ronald Nutt, on ... Montreal, Quebec, Canada. IEEE is the world,s largest ...
... Park, MD (June 22, 2010) -- The Human Genome Project, ... of hundreds of animal, plant, fungal, and microbe genomes in ... data with which researchers are struggling to keep pace. Knowing ... that genes play in the actual manifestation of physical traits ...
... ... risk management to be integrated on MetricStream GRC Platform , ... (PRWEB) June 22, 2010 -- SunTrust Banks, ... leader in Governance, Risk, Compliance (GRC) solutions, to integrate audit, compliance and risk ...
... ... the word about HIV prevention. , ... Chicago, IL (PRWEB) June 22, 2010 -- STDTestExpress , a service dedicated to ... HIV test with the purchase of an 8 Test Panel – a savings of $50. The ...
Cached Medicine News:Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 2Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 3Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 4Health News:UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital 5Health News:Aerohive Networks Appoints Dr. Lin Jiang as Vice President of Technical Operations 2Health News:Aerohive Networks Appoints Dr. Lin Jiang as Vice President of Technical Operations 3Health News:A*STAR scientist receives international award for innovation in healthcare technology 2Health News:New genetic analysis reveals principles of phenotypic expression 2Health News:MetricStream Selected by SunTrust for Enterprise-Wide GRC 2Health News:MetricStream Selected by SunTrust for Enterprise-Wide GRC 3Health News:STDTestExpress Highlights National HIV Testing Day with Free HIV Testing 2Health News:STDTestExpress Highlights National HIV Testing Day with Free HIV Testing 3
(Date:9/30/2014)...  Decision Resources Group finds that the Asia Pacific ... China , India , ... through 2023. Dental implant procedure volumes will grow as physicians are ... Other key findings from Decision Resources Group,s coverage of the ... , Dental implant penetration: Penetration of dental implants among the ...
(Date:9/30/2014)... -- Alimera Sciences, Inc. (NASDAQ: ALIM ) (Alimera), ... and commercialization of prescription ophthalmic pharmaceuticals, announced today that ... Technology Growth Capital, Inc. (NYSE: HTGC ) ... under the Loan and Security Agreement that Alimera,s subsidiary ... Sciences Limited, entered into with Hercules in April of ...
(Date:9/30/2014)... 2014 The Chinese wound care market is ... in the incidence of lifestyle diseases, coupled with the ... of better quality of wound care products provide the ... of public health insurance schemes and increased reimbursement rate ... on the findings of primary and secondary researches, this ...
Breaking Medicine Technology:Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3Alimera Sciences Receives $25 Million Advance from Hercules Technology Growth Capital 2China Wound Care Market 2China Wound Care Market 3
... HAYWARD, Calif., Feb. 1, 2011 Anthera Pharmaceuticals, Inc. ... drugs to treat serious diseases associated with abnormal auto-immune ... Dr. Peter Thompson to its Board of Directors. Currently, ... is the founder and Managing Director of Strategicon Partners, ...
... Mich., Feb. 1, 2011 Stryker Corporation (NYSE: ... previously announced sale of its OP-1 product family, which ... use in orthopaedic bone applications. The transaction also includes ... Stryker is one of the world,s ...
Cached Medicine Technology:Dr. Peter Thompson Joins Anthera Pharmaceuticals Board of Directors 2
Adjustable wire speculum with 17 mm open blades. Lid tension adjustable throughout procedure with thumb screw control. Shaft angled 45 degrees. Manufactured in titanium....
Solid 13.5 mm wide by 5 mm deep blades. Edge of blades serrated. Dull finish....
Adjustable lid speculum angled 45 degrees with 17 mm curved solid blades and aspiration ports to remove excess fluid from around the eye during ocular procedures....
Open 11 mm blades. Dull finish. Most popular size or model....
Medicine Products: