Navigation Links
Study shows that CPAP therapy reduces fatigue, increases energy in patients with sleep apnea
Date:12/31/2010

This release is also available in Chinese on EurekAlert! Chinese.

DARIEN, IL Patients with obstructive sleep apnea often report that they feel like "a new person" after beginning treatment with continuous positive airway pressure therapy. A new study in the Jan. 1 issue of the journal SLEEP provides objective evidence to support these anecdotal reports, showing that three weeks of CPAP therapy significantly reduced fatigue and increased energy in patients with OSA.

Results of the randomized controlled trial show that CPAP therapy significantly reduced self-reported, mean fatigue scores on two independent measures: from 8.76 at baseline to -0.10 post-treatment on the Multidimensional Fatigue Symptom Inventory Short Form; and from 7.17 at baseline to 4.03 post-treatment on the fatigue-inertia subscale of the Profile of Mood States Short Form. These results indicate that participants were no longer suffering from clinically significant levels of fatigue after the three-week intervention period.

Self-reported energy levels also increased after three weeks of CPAP therapy, with the mean score on the vigor-activity subscale of the Profile of Mood States Short Form increasing significantly from 14.28 at baseline to 16.52 post-treatment. Significant changes in fatigue and energy were not observed in participants who received placebo CPAP.

"This was one of the first double-blind studies of the effects of CPAP on fatigue," said lead author Lianne Tomfohr, graduate research assistant in the joint doctoral program at San Diego State University and the University of California, San Diego. "These results are important, as they highlight that patients who comply with CPAP therapy can find relief from fatigue and experience increases in energy and vigor after a relatively short treatment period."

Further analysis found that CPAP appeared to be especially beneficial for participants who were excessively fatigued or sleepy before treatment. CPAP therapy significantly reduced self-reported daytime sleepiness in this group, with their mean score on the Epworth Sleepiness Scale dropping from 13.0 at baseline to 8.9 post-treatment.

According to the American Academy of Sleep Medicine, OSA is a common sleep-related breathing disorder that affects at least two to four percent of the adult population. OSA occurs when the muscles relax during sleep, causing soft tissue in the back of the throat to collapse and block the upper airway. Most people with OSA snore loudly and frequently, and they often experience fatigue and excessive daytime sleepiness.

The treatment of choice for OSA is CPAP therapy, which provides a steady stream of air through a mask that is worn during sleep. This airflow keeps the airway open to prevent pauses in breathing and restore normal oxygen levels.

Tomfohr and a team of UCSD researchers studied 59 adults with a mean age of 48 years. Overnight polysomnography in a sleep lab confirmed that each participant had OSA, which was defined as having an apnea-hypopnea index (AHI) of 10 or more partial reductions (hypopneas) and complete pauses (apneas) in breathing per hour of sleep.

Participants were randomly assigned to receive either therapeutic CPAP or placebo CPAP, and they returned to the sleep lab for a night of either CPAP titration or mock titration. Participants were trained on the use of the equipment and instructed to use it at home each night for three weeks. Questionnaire data were obtained prior to study randomization and after the three-week intervention period.

According to the authors, the mechanisms that underlie the observed changes in fatigue are unclear. They speculate that CPAP may impact fatigue in patients with OSA by reducing inflammation, noting that increases in inflammatory markers in OSA patients have been related to elevated fatigue.


'/>"/>

Contact: Emilee McStay
emcstay@aasmnet.org
630-737-9700 x9345
American Academy of Sleep Medicine
Source:Eurekalert

Related medicine news :

1. Study finds evidence of increased lung cancer risk among tuberculosis patients
2. Urban Wildlife Adopt Not-so-Healthful Human Diet, Study Finds
3. First Impressions of Attractive People Often Correct: Study
4. Love of Possessions Can Run Deep, Study Shows
5. Anesthesiologists Spreading Germs During Surgery: Study
6. Hearing Loss Rising Among Teen Girls, Study Finds
7. Case Western Reserve receives $10M to study retinal disease, develop new treatments
8. Injectable, Oral Birth Control Dont Threaten Glucose, Insulin Levels: Study
9. People Look to Eyes for Signs of Life, Study Finds
10. Obese Drivers at Higher Risk of Death in Car Crashes: Study
11. Mortality rates are an unreliable metric for assessing hospital quality, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... 06, 2016 , ... U.S. Security Associates (USA) was named ... their industry leading training methods that engage their associates and link their achievements ... elite in employer-sponsored training and development programs. , “The 2017 Training Top 125 ...
(Date:12/5/2016)... ... ... For many years, Andrew G. Zubinas has accumulated over 130 hardcover ... Lithuanian language and its poetry inspired him in writing “ Forest Lungs ... aspects of a living, breathing forest where nothing ever stays the same. His subjects ...
(Date:12/5/2016)... ... 05, 2016 , ... “Epilepsy Awareness,” which can be found ... a conversation about epilepsy, bearing down on the social stigma and lack of ... with epilepsy within their lifetime. With such a large percentage of people affected, ...
(Date:12/5/2016)... , ... December 05, 2016 , ... BSI and Brenntag ... United States and Canada for distribution of their natural fruits and beverage ... is an exciting addition to our Life Sciences product portfolio,” said Steve Brauer, ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... portfolio company, today announced it has acquired the assets of Frankfurt, Germany ... a subsidiary of Chiltern International and focuses on clinical trial drug packaging, ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 5, 2016 Special purpose needles are used in ... fluid and cells from organs or lumps and are available ... The global market for special purpose needles is showing a ... of revenue, the global special purpose needles market is projected ... period (2016–2026) and is expected to be valued at US$ ...
(Date:12/5/2016)... Dec. 5, 2016  Pennsylvania Physician General Dr. ... Programs Gary Tennis today filled prescriptions for ... Pharmacy in York to demonstrate ... Dr. Levine as a prescription to acquire naloxone at ... important to remember that any Pennsylvanian can walk up ...
(Date:12/5/2016)... -- Research and Markets has announced the addition ... (Biomedical & Biochemical Research, Disease Diagnostics), End User (Academic & Research ... report to their offering. ... , The western blotting ... USD 574.8 Million in 2016, growing at a CAGR of 4.9%. ...
Breaking Medicine Technology: