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Study shows steroid therapies following transplant can be eliminated
Date:10/21/2008

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The results showed that early steroid elimination caused reduction in many steroid-related complications, even when prednisone was given in very low doses.

Kidney function was similar in both patient groups.

"By demonstrating identical kidney transplant survival and function for five years, we now have a scientific basis for offering steroid-free therapies in kidney recipients," Woodle says.

However, he notes that risk of rejection episodes in patients was slightly increased with early steroid discontinuation.

"These episodes were mild and easily treated," he says.

He adds that although the five-year kidney transplant survival and function were identical between those who received prednisone and those who received other immunosuppressive drugs in this study, it doesn't mean that it will be the same in 10 or 20 years.

"Our hope is that with our modern anti-rejection drugs and new drugs being developed, even this small risk of increased rejection combined with longer-term results will not be changed," he says.

The results of this study are now being used in different transplant populations, resulting in much lower prednisone doses or complete elimination with fewer complications.


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Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati
Source:Eurekalert

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