Navigation Links
Study shows steroid therapies following transplant can be eliminated
Date:10/21/2008

CINCINNATIA new study by researchers at the University of Cincinnati (UC) shows that using modern immunosuppressive drugs eliminates the need for steroid therapy as early as seven days following a transplant surgery while still maintaining kidney function.

Steve Woodle, MD, chief of UC's transplant surgery division, principal investigator and designer of the study, says the elimination of a daily dose of steroids following transplantation minimizes chronic health conditions common to kidney transplant recipients.

The datafrom what is believed to be the longest-running, double-blinded study of its kind in the transplant fieldis published in the October issue of the Annals of Surgery.

"Steroids have long been the primary source of morbidity and complications following successful kidney transplantation," Woodle says. "This study demonstrates that elimination of even small, daily prednisone (pred-ne-zone) doses does not compromise results while minimizing weight gain, diabetes and bone complications."

Corticosteroids were the first anti-rejection drug used in transplant patients, dating back to the first transplant surgeries over 50 years ago.

Traditionally patients who have undergone organ transplantation have required life-long steroid treatments given in combination with other drugs that help suppress the body's immune system and allow the transplanted organ to function properly.

However, the steroid treatmentgiven as the oral drug, prednisonecan cause serious side effects including cardiovascular disease, high cholesterol and blood pressure, weight gain, diabetes, bone weakness and cataracts.

To test the effectiveness of early elimination of steroids, researchers studied 397 patients from 25 U.S. kidney transplant centers for a five-year period following transplant. They administered low doses of prednisone to one group of transplant patients while the other group of patients received a placebo.

The results showed that early steroid elimination caused reduction in many steroid-related complications, even when prednisone was given in very low doses.

Kidney function was similar in both patient groups.

"By demonstrating identical kidney transplant survival and function for five years, we now have a scientific basis for offering steroid-free therapies in kidney recipients," Woodle says.

However, he notes that risk of rejection episodes in patients was slightly increased with early steroid discontinuation.

"These episodes were mild and easily treated," he says.

He adds that although the five-year kidney transplant survival and function were identical between those who received prednisone and those who received other immunosuppressive drugs in this study, it doesn't mean that it will be the same in 10 or 20 years.

"Our hope is that with our modern anti-rejection drugs and new drugs being developed, even this small risk of increased rejection combined with longer-term results will not be changed," he says.

The results of this study are now being used in different transplant populations, resulting in much lower prednisone doses or complete elimination with fewer complications.


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 18, 2017 , ... Western University of Health Sciences will ... launch the University’s new Center for Innovation on Wednesday, September 6, 2017. , The ... Hall 1, followed by a technology exhibition from 1 to 3 p.m. showcasing virtual ...
(Date:8/19/2017)... ... August 19, 2017 , ... The digital health ... organization with pending recognition status from the Centers for Disease Control and Prevention ... classes and live video conferencing. , The DPP resulted from clinical work ...
(Date:8/19/2017)... (PRWEB) , ... August 19, 2017 , ... Yesterday, the ... KKK by saying there are two sides. There are not two sides to hatred, ... to rationalize violence and prejudice, and the NPEIV stands against all forms of such ...
(Date:8/19/2017)... ... August 19, 2017 , ... “Congratulations! It's A Boy! ... children to both their parents and God. “Congratulations! It's A Boy! God’s Gift: A ... a couple from Long Island, New York. , Published by Christian Faith Publishing, Dale ...
(Date:8/18/2017)... ... August 18, ... ... For Immediate Release                Contact: Julian Teixeira, August 18, 2017                    202-478-8564 ... and Relationship Advice from their Fathers , Contrary to ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017  Axium Pharmaceuticals Inc., the creator of ... to be in the beginning stages of an IPO. ... epilepsy medications with the average cost of a prescription epilepsy drug being ... AXIUM ... Another staggering figure is the fact that ...
(Date:8/11/2017)... DarioHealth Corp. (NASDAQ: DRIO), a leading global ... solutions, today announced that it will release its second ... a conference call at 9:00am ET. The Company will ... and its strategy and outlook for the remainder of ... Raphael , Chief Executive Officer, and Zvi Ben-David ...
(Date:8/7/2017)... , Aug. 7, 2017 Insightin ... member acquisition, retention, and engagement, announced the selection ... Strategy and Product Development, effective as of February 2017. ... and technology implementation strategy for our clients. Wood ... experience in consulting and business analytics within the ...
Breaking Medicine Technology: