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Study shows splitting bowel preparation dosage is most effective cleansing method before colonoscopy
Date:8/5/2010

rated on a segmental scoring scale of one to four (four-excellent, three-good, two-fair and one-poor, see study for a more detailed description of the scale). On the morning of the colonoscopy, immediately before the procedure, a nurse questioned each patient about his or her experience regarding compliance with preparation instructions, tolerance, additional fluid intake, acceptability and willingness to repeat the same type of bowel preparation if necessary. Colonoscopies were performed by experienced colonoscopists unaware of the treatment allocation.

Results

Researchers found that study compliance in both groups was excellent, independent of the intake schedule: complete preparation (drinking the full amount of fluid indicated) was accomplished by 96.3 percent of the low-volume group patients and 95.8 percent of the high-volume group patients in the non-split dosage group, and 97.2 percent and 98.6 percent for both volumes respectively in the split-dosage group.

The split-dosage regimen produced markedly superior cleansing results over the non-split dosage regimen. Overall, a good/excellent degree of bowel cleansing was recorded in 75.2 percent of patients in the split-dosage group versus 43 percent of patients in the non-split-dosage group. The superiority of the split-dosage intake schedule was independent of the volume of PEG solutions. Both low-volume and high-volume PEG solutions produced the same degree of cleansing: 77 percent versus 73.4 percent respectively in the split-dosage group and 41.7 percent versus 44.3 percent, respectively, in the non-split-dosage group. The time elapsed between the last fluid intake and the colonoscopy was an important factor affecting the degree of bowel cleansing. The cleansing score decreased significantly after six to eight hours from the last fluid intake.

Both preparations were well-tolerated; patients reported no side effects. Overall, complete colonoscopy (intubation to the cecum)
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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