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Study shows splitting bowel preparation dosage is most effective cleansing method before colonoscopy
Date:8/5/2010

OAK BROOK, Ill. August 5, 2010 A new study from researchers in Italy has found that a split-dosage schedule of bowel (colon) preparation is the most effective method for bowel cleansing before colonoscopy. Colonoscopies performed within six to eight hours of the end of preparation were associated with significantly better cleansing than those performed more than eight hours after the end of preparation. Two different types of bowel cleansing products were also assessed and researchers found that low-volume polyethylene glycol (PEG) plus ascorbic acid was as effective as high-volume PEG-electrolyte solution, but has superior palatability (or taste). This is the first study to demonstrate that the advantage of split-dosage intake is also true for low-volume bowel cleansing solutions. The study appears in the August issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).

Diagnostic accuracy and therapeutic safety of colonoscopy depend on the quality of colon cleansing (the large intestine is referred to as the colon or large bowel). Inadequate bowel preparation can result in missed lesions, aborted procedures, and increased discomfort as well as a potential increase in complication rates. A standard bowel cleansing product is polyethylene glycol (PEG) taken in a large single dose (four liters), which is required for effective bowel cleansing. When taken in divided doses, a standard four-liter PEG dosage was demonstrated to be as effective as, and better tolerated than, the single dose given one day before the procedure. A new cleansing solution consisting of high molecular weight PEG plus ascorbic acid has been developed which reduces the volume patients have to drink without compromising efficacy or safety.

"The aims of this study were to evaluate the degree of colon cleansing in patients undergoing colonoscopy, comparing split-dosage versus no
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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