Navigation Links
Study shows short-term kidney failure in heart patients may not be as detrimental

CINCINNATINew research led by UC Health cardiologists shows that while short-term worsening kidney function is frequent among patients with heart failure, these patients also have better outcomes than those who have persistent kidney failure.

These findings, published in the July 2010 edition of the Journal of Cardiac Failure, could lead to more effective interventions and treatments for patients with heart failure that develop kidney problems or failure as well.

"Worsening renal function is a warning complication in patients with acute heart failure syndrome," says Andrew Burger, MD, UC Health cardiologist and co-investigator in the study. "Between 30 and 50 percent of patients hospitalized for acute heart failure have further worsening of renal function during hospitalization, but there is very little data available about the clinical implication of transient versus persistent worsening of renal function in this setting.

"This study is the first of its kind to look at this relationship to help physicians assess outcomes and possibly determine the most efficient way to treat heart patients who develop kidney failure at any degree."

Researchers studied 467 patients with acute heart failure syndrome and their creatinine measurements on days 2, 5, 14 and 30 of the study.

Creatinine is a product of creatine phosphate, or energy phosphate, in the muscle and brain. It is filtered out of the blood by the kidneys. If the filtering of the kidney is deficient, blood levels rise, and creatinine levels in blood and urine are used to calculate the kidney's function.

In this study, worsening renal function was defined as persistent when serum creatinine remained greater than 0.5 mg/dL (milligrams per deciliter) above baseline throughout to day 30 and transient when the elevated creatinine levels decreased to less than 0.5 mg/dL above baseline within the 30-day period.

"Worsening renal function occurred in 115 patients39 of those cases were considered transient," says Burger.

He adds that researchers saw death in 17.3 percent of patients without worsening renal function, 20.5 percent of patients with transient worsening dysfunction and 46.1 percent of patients with persistent renal dysfunction.

"The patients with no change in renal function and transient dysfunction have the same outcome, while patients with persistent renal dysfunction are more like to die," Burger says. "Chronic heart failure encompasses an important interaction between the heart and the kidneys, and renal dysfunction often accompanies heart failure.

"These findings give cardiologists some insight into the degree of renal dysfunction and its association with mortality in both stable and acute heart failure syndrome. Hopefully, these results will lead to further studies that may help in determining better interventions and outcomes for patients with acute heart failure."


Contact: Katie Pence
University of Cincinnati Academic Health Center

Related medicine news :

1. Casual Sex Doesnt Cause Emotional Damage: Study
2. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
3. Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
4. New study finds possible source of beta cell destruction that leads to Type 1 diabetes
5. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
6. Risk of stroke lower for recent Ontario immigrants: study
7. Definitive study confirms chemo benefit in postmenopausal breast cancer
8. Experimental stem cell treatment arrests acute lung injury in mice, study shows
9. Violence is part of the job say nurses as study shows only 1 in 6 incidents are reported
10. Controversial Autism Study Retracted by Medical Journal
11. Study Reveals Impact Of Health Insurance On Hispanics' Attitudes Towards Healthcare Providers
Post Your Comments:
(Date:11/25/2015)... ... ... “While riding the bus, I saw a passenger in a wheelchair drenched from ... a convenient and comfortable way to protect them from bad weather, so I invented ... during cold or inclement weather. In doing so, it ensures that the user remains ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care ... disease. The Periwinkle Pioneers, nominated by the public, will receive special recognition throughout ...
(Date:11/25/2015)... ... November 25, 2015 , ... An unlikely combination ... in a way for homeless people to have a more dignified and comfortable ... initiative whereby they are repurposing plastic bags into sleeping mats for the homeless. ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... focused on providing comprehensive solutions involving adult stem cell therapies to patients with ... deemed the “Regenestem” name as a Registered Trademark (RTM). , Organizations are required ...
(Date:11/24/2015)... ... 2015 , ... Genesis Chiropractic Software helps practice owners automate ... between the practice owner and the patient that automatically manages all five aspects ... Click here to learn more. , According to Dr. Brian ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 Kitov ... ) (TASE: KTOV), a biopharmaceutical company focused on the ... various clinical conditions, today announced the closing of its ... Shares ( ADSs ), each representing 20 ordinary shares ... 3,158,900 ADSs. The ADSs and warrants were issued in ...
(Date:11/25/2015)... , Nov. 25, 2015 Allergan ... pharmaceutical company, and Rugen Therapeutics, a start-up  biotechnology ... for unmet CNS disorders and funded by the ... they have entered into an exclusive collaboration to ... for Autism Spectrum Disorders (ASD) and Obsessive Compulsive ...
(Date:11/25/2015)... Israel , November 25, 2015 ... "New Investors"), pursuant to which BioLight and the New ... IOPtima Ltd. subsidiary ("IOPtima") via a private placement. The ... of its innovative IOPtimate™ system used in the treatment ... approval pathway process for the IOPtimate™ system with the ...
Breaking Medicine Technology: