Navigation Links
Study shows promise of preserving fertility in boys with cancer
Date:3/27/2014

WINSTON-SALEM, N.C. March 27, 2014 Scientists have moved a step closer to being able to preserve fertility in young boys who undergo chemotherapy and radiation treatments for cancer. The new research, published in Fertility and Sterility, the journal of the American Society for Reproductive Medicine, addresses the safety of an option scientists are developing for boys who aren't sexually mature and cannot bank sperm.

Scientists aim to freeze a sample of the boys' testicular tissue so that when they reach adulthood, spermatogonial stem cells (SSCs) found in the tissue can be reproduced and transplanted back into the patients. These cells are responsible for sperm production throughout adulthood.

"Our study addressed an important safety issue whether cancer cells that might be present in testicular tissue samples can survive the process to replicate the sperm-producing stem cells," said lead author Hooman Sadri-Ardekani, M.D., Ph.D., an instructor in urology and regenerative medicine at Wake Forest Baptist Medical Center.

"This is an important consideration because of the potential to re-introduce cancer into the patient," he said. "The research, which involved one of the most common childhood cancers, shows that the cancer cells were eliminated. Based on these findings, we recommend that all boys with cancer be offered the option of storing testicular tissue for possible future clinical use."

Sadri-Ardekani performed the work with researchers at the University of Amsterdam and Avicenna Research Institute in Tehran, Iran, before joining Wake Forest Baptist.

Cancers that can have a high risk of infertility, depending on the treatment, are certain leukemias, Hodgkin's disease, brain tumors and bone cancer. Because of the high survival rates of childhood cancer close to 80 percent more cancer patients than ever are reaching adulthood and many face fertility problems.

The current research involved acute lymphoblastic leukemia (ALL) cells, a common type of childhood cancer. Previous research had shown that up to 30 percent of boys with ALL had cancer cells in their testicular tissue.

Several earlier studies have attempted to eliminate cancer cells from biopsy tissue, but they showed contradictory results. The approach of Sadri-Ardekani and colleagues was to investigate whether cancer cells would survive the laboratory protocol they had developed to reproduce SSCs from a small tissue biopsy. This process multiplies the original SSCs by 18,000-fold so there are enough cells to transplant back into the patient when he reaches adulthood.

For the research, ALL cells were taken from three patients' bone marrow. The team then put the ALL cells alone, and ALL cells combined with testicular cells, through the cell-reproduction process.

Even when ALL cells made up 40 percent of the cell mixture being cultured, they were entirely eliminated in 26 days of culture.

"This pilot study showed that the culture system not only allowed for efficient propagation of sperm stem cells, but also eliminated ALL cells," said Sadri-Ardekani.

SSC transplantation has not yet been attempted in humans, but has been performed successfully in several species of animals, including monkeys, said Sadri-Ardekani. He noted that before physicians and scientists begin offering SSC transplantation in patients, additional research will be needed, including whether other types of leukemia cells will also be eliminated in the cell-propagation process.


'/>"/>

Contact: Karen Richardson
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Scripps Florida scientist awarded $2.3 million to study dengue fever and related viruses
2. Hormone levels linked to survival of deer calves, study suggests
3. Study identifies key player in motor neuron death in Lou Gehrigs disease
4. Statins could ease coughing in lung disease patients, study finds
5. HPV eradicated by AHCC supplement, preclinical study suggests
6. Study links tooth loss to depression and anxiety
7. USF study finds stem cell combination therapy improves traumatic brain injury outcomes
8. IU, Regenstrief study: New noninvasive colorectal cancer screening tool highly accurate
9. Sepsis study comparing 3 treatment methods shows same survival rate
10. Better continuity of care for elderly pataients cuts costs and complications, study finds
11. US headache sufferers get $1 billion worth of brain scans each year, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... Georgia (PRWEB) , ... June 24, 2016 , ... ... awards today at the Clinical Decision Making in Emergency Medicine conference in Ponte ... have authored journal articles published in Emergency Medicine Practice and Pediatric ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today that ... Supplier Horizon Award . One of ... was recognized for its support of Premier members through ... clinical excellence, and commitment to lower costs. ... this recognition of our outstanding customer service from Premier," ...
Breaking Medicine Technology: