Navigation Links
Study shows promise for new cancer-stopping therapy
Date:6/11/2009

nder of the liver. This demonstrates for the first time that therapeutic delivery of a miRNA in an animal can result in tumor suppression, without the need for specifically targeting the cancer causing oncogene.

"We are eagerly looking forward to applying this methodology to other tumor types in the laboratory and potentially bringing this approach forward for clinical testing in patients," said Jerry Mendell, MD, director, Center for Gene Therapy in The Research Institute at Nationwide Children's Hospital and a faculty member of The Ohio State University College of Medicine. "While there remains significant work to be done both in identifying such miRNAs and optimizing their delivery, our findings highlight the therapeutic promise of this approach."

The findings of therapeutic miRNA gene replacement in HCC has potential for applicability to other types of cancers, as well. The delivery and restoration of miRNA expression via AAV mediated gene transfer of the miRNA may be beneficial to a large number of cancer subtypes.

"This concept of replacing microRNAs that are expressed in high levels in normal tissues but lost in diseases hasn't been explored before," said Josh Mendell, M.D., Ph.D., an associate professor in the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine. "Our work raises the possibility of a more general therapeutic approach that is based on restoring microRNAs to diseased tissues."


'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@nationwidechildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study finds segregation decreases access to surgical care for minorities
2. Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury
3. Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury
4. PAREXEL Enhances Study Start-Up and Recruitment Capabilities With Appointment of Dr. Lars-Olof Eriksson, Formerly With Merck
5. Want to Learn How to Testify? New Home Study Course by Practicing Physician Teaches Medical Malpractice Defendants and Physicians How to be Effective in Court
6. Morning Sickness Drug Gets Green Light in Study
7. DaVita Study Demonstrates Clinical Application of Sysmex Reticulocyte Hemoglobin Equivalent (RET-He) Parameter
8. New Study Shows Coaching to Patient Activation Levels Improves Disease Management Outcomes
9. New Jefferson study may redefine how a chronic auto-immune disease is diagnosed
10. ASCO Research Foundation Grant Will Support Study of Peregrines Bavituximab in Lung Cancer
11. Published Study Shows VNUS ClosureFAST™ System Significantly Superior to Laser for Varicose Vein Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... with severe disabilities and multiple chronic conditions are screened ... disabilities or no chronic conditions, a new study has ... women with moderate disabilities or women with only one ... scientist with the Li Ka Shing Knowledge Institute of ... disabilities often have other measures of social vulnerability, such ...
(Date:8/22/2014)... NY (PRWEB) August 22, 2014 Ticket ... Caputo tickets in Kalamazoo, New Orleans, Albuquerque and Rapid ... death, the “Long Island Medium,” Theresa Caputo, allows just that. ... Island. She is part of a close knit family who ... speaking with a spiritual healer, realized she had a chance ...
(Date:8/22/2014)... “Dr. Luciana Show – Aging and Falling” is currently ... finding it challenging to stay on top of post-production tasks ... of students, so the editing of the episodes will take ... she recently entered it into the festival circuit. , ... actor/screenwriter Gregory Graham , the aging and falling show ...
(Date:8/22/2014)... (ESMO), the leading pan-European organisation representing medical oncology ... individuals receiving the Society,s esteemed annual awards. The ... Joensuu and Peter Boyle on the occasion of ... , Carsten Bokemeyer will receive the ESMO Award ... cancer discovery into real benefit at patient level. ...
(Date:8/22/2014)... approx. 265,000 Danes are acutely admitted to medical departments ... University and Aarhus University Hospital now shows that many ... are sent home again without receiving a diagnosis ... hospitalisation., "Naturally, there is no need for a diagnosis ... is a serious illness. So some patients will always ...
Breaking Medicine News(10 mins):Health News:Women with severe, chronic health issues are screened for breast cancer less often 2Health News:Theresa Caputo Tickets in Kalamazoo at Wings Stadium, Saenger Theatre in New Orleans, Kiva Auditorium in Albuquerque and Rapid City at Don Barnett Arena Now Available 2Health News:Professor Luciana Lagana Dedicates to Her CSUN Students the “Dr. Luciana Show-Aging and Falling” AOF Festival Nomination (Screening at Krikorian Monrovia Cinema on 08/25) 2Health News:Professor Luciana Lagana Dedicates to Her CSUN Students the “Dr. Luciana Show-Aging and Falling” AOF Festival Nomination (Screening at Krikorian Monrovia Cinema on 08/25) 3Health News:Professor Luciana Lagana Dedicates to Her CSUN Students the “Dr. Luciana Show-Aging and Falling” AOF Festival Nomination (Screening at Krikorian Monrovia Cinema on 08/25) 4Health News:ESMO honors outstanding oncology professionals 2Health News:ESMO honors outstanding oncology professionals 3Health News:Many patients are discharged without a diagnosis 2
... , MONDAY, April 23 (HealthDay News) -- Studies that ... are more likely to get published in medical journals ... such as rocking and hand-flapping, new research says. ... medications -- known as selective serotonin reuptake inhibitors (SSRIs) ...
... landmark clinical trial in Canada demonstrated the unequivocal effectiveness ... then the procedure has not been widely adoptedin fact, ... from the University of California, San Francisco (UCSF). ... Neurology , showed that the number of Americans having ...
... at 3 and I will give you the adult compulsive ... in Psychological Science , a journal published by the ... 900 individuals beginning in toddlerhood, the study found that "people ... inattentive, oppositional, and moody than other three-year old children were ...
... April 23, 2012 Most people go through life ... life-altering experience makes those goals become unachievable or even ... Psycho-Oncology by Carsten Wrosch of Concordia University,s ... Development and Catherine Sabiston of McGill,s Department of Kinesiology ...
... Nigeria,s top government officials, civil society leaders and leaders ... vaccine access nationwide, a major step in the fight to ... highest number of child deaths. Among other commitments, the First ... the sustained introduction and scale-up of childhood vaccines as well ...
... Next time you need to choose between vegetable oil and ... reach for the oil. While the question of whether vitamin ... scientific journals and in the news media, scientists at the ... Pharmacy, and the Cancer Institute of New Jersey, believe that ...
Cached Medicine News:Health News:'Publication Bias' Casts Doubt on Value of Antidepressants for Autism 2Health News:'Publication Bias' Casts Doubt on Value of Antidepressants for Autism 3Health News:Brain surgery for epilepsy underutilized 2Health News:Brain surgery for epilepsy underutilized 3Health News:That impulsive, moody preschooler may grow up to be a problem gambler 2Health News:Letting go can boost quality of life 2Health News:Groundbreaking Nigeria summit results in major commitment to reduce child deaths 2Health News:Vitamin E in diet protects against many cancers 2
(Date:8/21/2014)... 2014 The spinal column is one of the ... carried to and from the brain through the column control ... Injury or ailment here can be life altering, and leave ... control over their body. Though back injury and disease can ... are more options available to make things better than ever ...
(Date:8/21/2014)... Aug. 21, 2014 /CNW/ - The Canadian Epilepsy Alliance (CEA) ... series designed to educate children about the most common neurological ... Medikidz Explain Epilepsy comic series tells a fictional story ... middle school while living with epilepsy. "Despite ... is still so much misinformation and lack of awareness out ...
(Date:8/21/2014)... , N.Y. and HAMBURG, Germany , ... announced it is collaborating with Deutsches Elektronen-Synchrotron ( DESY ... Germany , to speed up management and storage ... Big Data and Analytics architecture based on IBM ... per second of data at peak performance and help ...
Breaking Medicine Technology:Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Action Heroes Harness Powers to Educate Children About Epilepsy 2Action Heroes Harness Powers to Educate Children About Epilepsy 3DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3
... , ... ... ... ...
... , ... ... ... ...
Cached Medicine Technology:Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 2Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 3Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 4Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 5Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 6Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 7Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 8Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 9Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 10Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 11Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 12Microfluidics International Corporation Announces Fourth Quarter and Year-End 2009 Financial Results 13InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 2InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 3InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 4InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 5InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 6InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 7InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 8InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 9InteractElsevier Delivers 3-D Interactive Anatomy Learning Tools 10
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: