Navigation Links
Study shows promise for new cancer-stopping therapy
Date:6/11/2009

Researchers at Nationwide Children's Hospital and Johns Hopkins University have discovered that delivering a small molecule that is highly expressed in normal tissues but lost in diseased cells can result in tumor suppression.

MicroRNAs (miRNA) are a class of small RNA molecules that are highly expressed in normal tissues and are critical in gene expression and in maintaining normal cell development and cell balance. Dysfunction of miRNAs has been linked to multiple human diseases including schizophrenia, autism and cancer.

"The pattern of expression of miRNAs has emerged as critically useful information for understanding cancer development and could be used to establish prognosis and treatment responses," said Janaiah Kota, PhD, a postdoctoral scientist from Nationwide Children's.

In a study reported in Cell (June 12, 2009), the team of researchers employed a novel strategy to treat an important form of cancer. Studies targeted hepatocellular (liver) cancer (HCC), the third leading cause of cancer-related deaths. HCC is commonly associated with underlying liver abnormalities, such as hepatitis B and C infections and cirrhosis. HCC is difficult to treat since it is often diagnosed at an advanced stage and because its biologic composition makes the tumor highly resistant to current drug therapies. However, the research reported in Cell suggests that miRNA gene delivery may be a clinically viable therapy when delivered by a recombinant adeno-associated virus (AAV).

HCC expresses a reduced number of miRNAs, including miR-26a. By combining miRNA technology developed at Johns Hopkins University with the gene delivery expertise of Nationwide Children's Hospital, scientists were able to successfully deliver AAV carrying miR-26a to a mouse with established HCC. This gene therapy strategy inhibited growth of cancer cells and led to tumor reduction and cell death, without causing toxic side effects to the remai
'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@nationwidechildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study finds segregation decreases access to surgical care for minorities
2. Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury
3. Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury
4. PAREXEL Enhances Study Start-Up and Recruitment Capabilities With Appointment of Dr. Lars-Olof Eriksson, Formerly With Merck
5. Want to Learn How to Testify? New Home Study Course by Practicing Physician Teaches Medical Malpractice Defendants and Physicians How to be Effective in Court
6. Morning Sickness Drug Gets Green Light in Study
7. DaVita Study Demonstrates Clinical Application of Sysmex Reticulocyte Hemoglobin Equivalent (RET-He) Parameter
8. New Study Shows Coaching to Patient Activation Levels Improves Disease Management Outcomes
9. New Jefferson study may redefine how a chronic auto-immune disease is diagnosed
10. ASCO Research Foundation Grant Will Support Study of Peregrines Bavituximab in Lung Cancer
11. Published Study Shows VNUS ClosureFAST™ System Significantly Superior to Laser for Varicose Vein Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... intent on promoting innovation and fuelled by the brain ... Chinas health biotech industry only needs a more favourable ... the production of therapies and medicines both new ... study. , Long considered a skillful product replicator, China ...
... most people who made a New Year,s,resolution over the ... but for those looking to eat healthier and get ... boost the odds of success. What,s,more, it comes with ... the feel-good reward of home cooking and the potential ...
... Spiraling costs for seniors underscore need for Congress to ... has found,that 75 percent of Medicare drug plans continue ... average increase of $369 for five,commonly used drugs, between ... six plans tracked increased prices on the five drugs ...
... Survey finds that seven out of 10 shoppers in the Northeast are ... than they were ... just one year ago, DEERFIELD, Ill., ... the government when it comes to,the safety of food purchased in their ...
... 7 Boston Scientific,Corporation (NYSE: BSX ) today ... affirmed a District Court ruling which found that the,NIR(R) ... Johnson & Johnson.,The Appeals Court also reversed the District ... the infringement of that claim. The Appeals,Court remanded the ...
... have had a colonoscopy can play a life-saving role ... own colorectal cancer screenings, according to new research from ... coaches can provide important information to combat myths and ... patients say their doctors often fail to address. In ...
Cached Medicine News:Health News:China's biotech industry: An Asian dragon is growing 2Health News:China's biotech industry: An Asian dragon is growing 3Health News:China's biotech industry: An Asian dragon is growing 4Health News:China's biotech industry: An Asian dragon is growing 5Health News:China's biotech industry: An Asian dragon is growing 6Health News:China's biotech industry: An Asian dragon is growing 7Health News:New meal planning website launches just in time to help today's busy, health-conscious families and individuals to beat the odds when it comes to keeping their New Year's resolutions around eating healthier and getting organized 2Health News:Most Medicare Drug Plans Continue to Hike Costs into 2008 Two-to-Three Times Rate of Inflation 2Health News:Most Medicare Drug Plans Continue to Hike Costs into 2008 Two-to-Three Times Rate of Inflation 3Health News:EggFusion Helps Retailers Address Consumers' Food Safety Concerns 2Health News:EggFusion Helps Retailers Address Consumers' Food Safety Concerns 3Health News:Boston Scientific Announces Court Decision 2Health News:Colonoscopy fears overcome when patients support patients 2Health News:Colonoscopy fears overcome when patients support patients 3
(Date:12/24/2014)... ResMed (NYSE: RMD ) today announced ... medical device manufacturer BMC Medical Co., Ltd. ... listed below infringe ResMed,s patents, and entered an order prohibiting ... the United States : , iVolve ... Willow nasal pillows mask , iVolve full face mask ...
(Date:12/24/2014)... Ohio , Dec. 23, 2014   ... treatment decision support to healthcare providers for behavioral ... it has secured $30 million in equity financing ... Virginia C. Drosos , President and Chief Executive ... clinical adoption and development of Assurex Health,s ...
(Date:12/24/2014)... , Dec. 23, 2014 Tianyin Pharmaceutical ... that specializes in patented biopharmaceutical, modernized traditional Chinese ... (API) today announced that the Company achieved the ... Manufacturing Practice (GMP) certificate of TPI,s Qionglai Facility ... (CFDA). The public notice period is a significant ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... cleared device to identify the, lipid core (fatty) coronary ... ... BURLINGTON, Mass., May 15 InfraReDx, Inc. today,announced that physicians ... LipiScan(TM) Coronary Imaging System in a patient,undergoing a cardiac catheterization. ...
... Pharma today,announced that the United States Food and ... Terguride for the treatment of pulmonary,arterial hypertension (PAH). ... pivotal Phase II trial in Europe., "The ... for PAH,encourages and strengthens our development program by ...
Cached Medicine Technology:First Use in a Patient of The InfraReDx LipiScan(TM) Coronary Imaging System 2First Use in a Patient of The InfraReDx LipiScan(TM) Coronary Imaging System 3First Use in a Patient of The InfraReDx LipiScan(TM) Coronary Imaging System 4Terguride Receives FDA Orphan Drug Designation for the Treatment of Pulmonary Arterial Hypertension 2
... Ankle/Brachial Index (ABI) testing, Nicolet Vascular has ... It includes a 10-minute compact disk ABI ... any computer with a CD drive. It ... ABI test, provides information on the materials ...
... Triad Skull Clamp, compatible with the full ... of clamping force on all three skull ... the possibility of adjusting the force on ... be increased or decreased by adjusting the ...
... Advanced engineering, rapid acquisition of data, ... it the most accurate autorefractor available. ... High Quality Monitor allows for easy ... are taken as soon as focus ...
... Clinitek Microalbumin Strips provide albumin, creatinine and ... Clinitek Microalbumin product is useful to test ... hypertension in order to detect early kidney ... of the urinary albumin excretion rate, is ...
Medicine Products: