Navigation Links
Study shows promise for new cancer-stopping therapy
Date:6/11/2009

Researchers at Nationwide Children's Hospital and Johns Hopkins University have discovered that delivering a small molecule that is highly expressed in normal tissues but lost in diseased cells can result in tumor suppression.

MicroRNAs (miRNA) are a class of small RNA molecules that are highly expressed in normal tissues and are critical in gene expression and in maintaining normal cell development and cell balance. Dysfunction of miRNAs has been linked to multiple human diseases including schizophrenia, autism and cancer.

"The pattern of expression of miRNAs has emerged as critically useful information for understanding cancer development and could be used to establish prognosis and treatment responses," said Janaiah Kota, PhD, a postdoctoral scientist from Nationwide Children's.

In a study reported in Cell (June 12, 2009), the team of researchers employed a novel strategy to treat an important form of cancer. Studies targeted hepatocellular (liver) cancer (HCC), the third leading cause of cancer-related deaths. HCC is commonly associated with underlying liver abnormalities, such as hepatitis B and C infections and cirrhosis. HCC is difficult to treat since it is often diagnosed at an advanced stage and because its biologic composition makes the tumor highly resistant to current drug therapies. However, the research reported in Cell suggests that miRNA gene delivery may be a clinically viable therapy when delivered by a recombinant adeno-associated virus (AAV).

HCC expresses a reduced number of miRNAs, including miR-26a. By combining miRNA technology developed at Johns Hopkins University with the gene delivery expertise of Nationwide Children's Hospital, scientists were able to successfully deliver AAV carrying miR-26a to a mouse with established HCC. This gene therapy strategy inhibited growth of cancer cells and led to tumor reduction and cell death, without causing toxic side effects to the remai
'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@nationwidechildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study finds segregation decreases access to surgical care for minorities
2. Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury
3. Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury
4. PAREXEL Enhances Study Start-Up and Recruitment Capabilities With Appointment of Dr. Lars-Olof Eriksson, Formerly With Merck
5. Want to Learn How to Testify? New Home Study Course by Practicing Physician Teaches Medical Malpractice Defendants and Physicians How to be Effective in Court
6. Morning Sickness Drug Gets Green Light in Study
7. DaVita Study Demonstrates Clinical Application of Sysmex Reticulocyte Hemoglobin Equivalent (RET-He) Parameter
8. New Study Shows Coaching to Patient Activation Levels Improves Disease Management Outcomes
9. New Jefferson study may redefine how a chronic auto-immune disease is diagnosed
10. ASCO Research Foundation Grant Will Support Study of Peregrines Bavituximab in Lung Cancer
11. Published Study Shows VNUS ClosureFAST™ System Significantly Superior to Laser for Varicose Vein Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... (PRWEB) August 21, 2014 The results ... today in The Journal of the American Medical Association ... invasive cancers and reduces unnecessary recalls. Memorial Healthcare System ... the study. , “This study confirms what we already ... harmful cancers we want to find and, at the ...
(Date:8/21/2014)... According to a new market report published ... - Home Theatre in-a-box, Home audio systems, Home radios, ... Size, Share, Growth, Trends and Forecast, 2013 - 2019,” ... 2012 and is expected to reach USD 20.68 billion ... 2013 to 2019. Europe was the largest contributor to ...
(Date:8/21/2014)... (HealthDay News) -- In a new review of seafood ... eating tuna due to concerns about mercury exposure. ... only to shrimp as the most commonly eaten seafood ... avoid all tuna," Jean Halloran, director of food policy ... Reports, said in a news release from the group. ...
(Date:8/21/2014)... 2014 Pleio, Inc., a leader ... a new suite of services for retail and ... pharmacy by applying proven behavior shaping programs to ... increased medication adherence, higher PDC scores and improved ... PDC-targeted offerings align retail’s desire to meet health ...
(Date:8/21/2014)... 21, 2014) An international scientific collaboration led by ... alterations that may contribute to a rare form of ... rare cancer but other types as well. , The ... Cancer Genome Atlas initiative , completed the sequence ... today in the journal Cancer Cell . ...
Breaking Medicine News(10 mins):Health News:Dr. Mary Hayes: Study Shows 3D Mammography Finds More Invasive Cancers While Reducing Unnecessary Recalls 2Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 2Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 3Health News:Consumer Reports Advises Pregnant Women to Avoid Tuna 2Health News:Pleio, Inc. Expands Adherence Offerings For Retail Pharmacy 2Health News:Sequence of rare kidney cancer reveals unique alterations involving telomerase 2Health News:Sequence of rare kidney cancer reveals unique alterations involving telomerase 3
... MOUND, Texas, Jan. 16 American,HealthChoice, Inc. (Pink Sheets: ... and Tennessee, today, in an update for Company,shareholders, said ... 2007,totaled $243,000., "It was a year of positioning, ... CEO. "I am updating our shareholders on these,achievements as ...
... Jan. 16 Americans consume more calories as a,nation on ... year, save,Thanksgiving. By the time the final whistle blows at ... from greasy pizza,fried chicken wings, and beer., But this ... length of the,football field 109 times to burn off all ...
... faster with program established in Ottawa, Canada , , WEDNESDAY, ... Ottawa, Canada, designed to rush heart attack patients to ... time it took to perform the potentially lifesaving procedure, ... which a balloon is threaded into a blood vessel ...
... , Ohio Rehabilitation specialists guiding injured workers back ... their assessments and planning, new research suggests. , ... harder time returning to employment if their schedules routinely ... Ohio State University study. Those who work more than ...
... in the lungs of patients diagnosed with idiopathic ... University of Cincinnati (UC) researchers have discovered. , ... neutrophil (pronounced new-tro-fil) cellsa type of white blood ... percent increased risk of mortality in the first ...
... ... Women, ST. LOUIS, ... nearly 2,400 deaths each day,in the United States, an average of one ... percent of the total U.S.,female population, there,s more reason than ever to ...
Cached Medicine News:Health News:American HealthChoice CEO Dr. J.W. Stucki Provides Company Update 2Health News:American HealthChoice CEO Dr. J.W. Stucki Provides Company Update 3Health News:Eat This, Not That!(TM): 5 Smart Super Bowl Swaps That Will Save You Hundreds of Calories 2Health News:Specialized System Speeds Heart Attack Treatment 2Health News:Specialized System Speeds Heart Attack Treatment 3Health News:Extended work hours should factor into return to job after injury 2Health News:Extended work hours should factor into return to job after injury 3Health News:Rare lung disease cells indicate higher death risk 2Health News:Women May Enjoy Boost of Heart Health With Soy 2
(Date:8/20/2014)... 20, 2014  The National Association of Drug ... achieved by the real-time, pseudoephedrine (PSE) blocking system ... Log Exchange (NPLEx), automatically blocks unlawful PSE sales ... offenders and make arrests. Data released by NPLEx ... blocked the sale of more than 32,105 ...
(Date:8/20/2014)...  The National Association of Drug Diversion Investigators ... the real-time, pseudoephedrine (PSE) blocking system in Michigan. The ... (NPLEx), automatically blocks unlawful pseudoephedrine sales and helps ... make arrests. Data released by NPLEx shows electronic ... the sale of more than 32,890 boxes of medicine ...
(Date:8/20/2014)... YORK , Aug. 20, 2014 /PRNewswire/ ... research report is available in its catalogue: ... in France, Key Trends and Opportunities to ... Synopsis The report provides in ... the French personal accident and health insurance ...
Breaking Medicine Technology:Indiana's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Michigan's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23
... MASI ) announced today that it will release fourth ... 31, 2011, after the market closes on February 14, 2012. The ... PT (4:30 p.m. ET) and will be hosted by Joe Kiani, ... Vice President and Chief Financial Officer. A live webcast ...
... BEACH, Fla., Jan. 26, 2012 China Nuvo Solar ... name change to SurgLine International, Inc. has been completed ... under the new OTC ticker symbol: SGLN, effective tomorrow, ... owned operating subsidiary of SGLN. Thomas Toland, ...
Cached Medicine Technology:Masimo to Report Fourth Quarter and Full Year 2011 Financial Results After Market Close on February 14, 2012 2Masimo to Report Fourth Quarter and Full Year 2011 Financial Results After Market Close on February 14, 2012 3China Nuvo Solar Energy, Inc. Completes Name Change to SurgLine International, Inc. 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: