Navigation Links
Study shows no increased risk for heart attacks among HIV-positive patients with high CD4 cell count
Date:10/24/2013

OAKLAND, Calif., October 24, 2013 Patients who are HIV-positive and have high CD4 cell counts or have a high number of white blood cells that fight infections aren't at an increased risk for heart attacks compared to patients who are HIV-negative, according to a Kaiser Permanente study that appears in the current online issue of the Journal of Acquired Immune Deficiency Syndromes.

The study population included 22,081 HIV-positive and 230,069 demographically matched HIV-negative subjects from Kaiser Permanente Northern California (1996-2009) and Kaiser Permanente Southern California (2000-2009) health plan members. Researchers determined that individuals with lowest-recorded CD4 cell counts of 500 or more had no greater risk of a heart attack than HIV-negative subjects. A CD4 cell count below 500 cells per microliter is considered a sign of a weakened immune system.

"We found that HIV-positive patients with a history of very low CD4 cell counts of 200 or below had a 74 percent higher risk for a heart attack compared with HIV-negatives, while those who maintained a CD4 cell count of 500 or more had the same risk compared with HIV-negatives," said lead author Michael J. Silverberg, PhD, MPH, a senior research scientist with the Division of Research and director of the Kaiser Permanente Northern California HIV Registry, which includes all known cases of HIV infection within the health care system dating back to the start of the HIV/AIDS epidemic.

In recent years, as widespread use of more effective antiretroviral medications has resulted in an aging HIV-infected population, it has become important to document whether age-related diseases, such as heart attacks, are occurring at similar or higher rates than the general population.

HIV-positive individuals are known to have higher risk of heart attacks because they are more likely to smoke and to smoke heavily compared to the general population. In addition, some HIV therapies may increase cholesterol levels and certain HIV drugs may have direct effects on plaque formation that increase the likelihood of a heart attack.

"It is biologically plausible that lowest recorded CD4 cell count acts as a risk factor for heart attack since atherosclerosis is considered a consequence of a chronic inflammation," said senior author Daniel B. Klein, MD, chief of infectious diseases for Kaiser Permanente Hayward-Fremont, who has treated HIV-infected individuals for more than 25 years and was among the first to describe the association between HIV and heart disease. "The strong observed association for lowest recorded CD4 cell count and myocardial infarction risk likely reflects the fact that it is a good surrogate for increased duration of immunosuppression and HIV-associated inflammation."

According to the researchers, these findings suggest that the higher heart attack risk in this population with a history of very low CD4 cell counts may not be easily reversible, even with effective antiretroviral therapy. The results support increased efforts to diagnose and treat HIV as early as possible before CD4 cell counts have declined significantly. Early initiation of antiretroviral therapy, if combined with aggressive cardiovascular disease risk-factor management such as smoking cessation, might result in a similar overall heart-attack risk for HIV-positive individuals compared with the general population.

This study is part of Kaiser Permanente's ongoing efforts to understand the impact of HIV. In August of this year, Kaiser Permanente released a study that found HIV-positive patients who miss at least one medical office visit in the first year after their HIV diagnosis have a 71 percent increased risk of death in comparison with HIV-positive patients who did not miss office visits. And in January of this year, researchers found that HIV-positive patients have a higher incidence of nonmelanoma skin cancers.


'/>"/>

Contact: Rowena Sara
rsara@golinharris.com
415-318-4376
Kaiser Permanente
Source:Eurekalert

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... , ... Japanese Zen artist couple, Fumie and Kentaro Mune, have announced to ... at Miranda Kuo Gallery on Lower East Side, NYC. This exhibition will feature some ... Wanderlust , one of the largest US yoga online media outlets in the world, ...
(Date:9/21/2017)... ... 2017 , ... FlipBelt, the fitness brand that specializes in problem solving fitness ... market with the launch of their FlipBelt Crops. , The new fitness bottoms feature ... fingertips while at the gym, on the trail, or on-the-go. , “We always thought ...
(Date:9/21/2017)... , ... September 21, 2017 , ... ... offices serving communities in northern Alabama and Georgia, is embarking on an extended ... by utilizing modern early detection methods. , US Breast Cancer statistics show ...
(Date:9/20/2017)... ... 20, 2017 , ... Reflections Recovery Center, a men-only drug ... Joint Commission for chemical dependency and behavioral health services. , The Joint Commission ... that meet the commission’s rigorous standards. Accreditation by The Joint Commission is the ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... Plus Coating System for clients that rely on safety and cleanliness. This unique ... microorganisms. , Silver has been used for centuries for its antimicrobial properties. Unlike ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... , Sept. 6, 2017   PDI , a leader ... will host an educational session focused on the role ... (CLABSI) prevention at the 2017 Annual Scientific Meeting of ... take place at the Phoenix ... from Sept. 16-19, will also feature PDI,s Prevantics® ...
(Date:9/6/2017)... Eli Lilly and Company (NYSE: LLY ) ... and lasmiditan, two investigational treatments for migraine, at the ... place Sept. 7-10 in Vancouver . ... from an open-label study evaluating the safety and effectiveness ... mg) for the prevention of migraine. Galcanezumab is a ...
(Date:9/5/2017)... , Sept. 5, 2017  Xyntek Inc. has announced another milestone in their ... Midwest office to meet the growing demands of customer engagements regionally.  ... Xyntek's new Midwest office is located at 318 West Adams ... ... engagements regionally. ...
Breaking Medicine Technology: