Navigation Links
Study shows new evidence of age-related decline in the brain's master circadian clock
Date:7/19/2011

A new study of the brain's master circadian clock known as the suprachiasmatic nucleus, or SCN reveals that a key pattern of rhythmic neural activity begins to decline by middle age. The study, whose senior author is UCLA Chancellor Gene Block, may have implications for the large number of older people who have difficulty sleeping and adjusting to time changes.

"Aging has a profound effect on circadian timing," said Block, a professor of psychiatry and biobehavioral sciences and of physiological science. "It is very clear that animals' circadian systems begin to deteriorate as they age, and humans have enormous problems with the quality of their sleep as they age, difficulty adjusting to time-zone changes and difficulty performing shift-work, as well as less alertness when awake. There is a real change in the sleepwake cycle.

"The question is, what changes in the nervous system underlie all of that? This paper suggests a primary cause of at least some of these changes is a reduction in the amplitude of the rhythmic signals from the SCN."

The SCN, located in the hypothalamus, is the central circadian clock in humans and other mammals and controls not only the timing of the sleepwake cycle but also many other rhythmic and non-rhythmic processes in the body.

The UCLA research team examined the SCN in mice and found that while critical neural activity rhythms were already disrupted in middle age, the molecular mechanisms that generate these rhythms were not significantly altered.

"These results indicate that the outputs of the central circadian clock start to decline in middle age and suggest that the same may be true in humans," said study co-author Christopher Colwell, a UCLA professor of psychiatry and biobehavioral sciences who has conducted research with Block for many years. "Before this study, we did not know that the SCN was the site where the decline occurs."

In a technical tour de force, th
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Kids Fare Better in Crashes When Grandparents Driving: Study
2. Sharing Bed With Toddler Wont Harm Development: Study
3. Small Study Suggests Milk, Soy Proteins Lower Blood Pressure Modestly
4. IADR/AADR publish study on use of Twitter for public health surveillance of dental pain
5. Ex-NFL Players May Face Higher Brain Damage Risk, Study Says
6. Self-Esteem Levels Vary by Age, Race, Study Finds
7. Injection Drug Users Most in Need of Treatment, Study Says
8. Suicide Among Veterans All Too Common, Study Finds
9. Certain Painkillers May Raise Odds of Stroke, Heart Attack: Study
10. Pets Pump You Up, Study Finds
11. Rat Study Shows How Binge Drinking Harms Memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... (PRWEB) December 22, 2014 Christmas is days ... has a fast and easy solution that will please: the ... can be purchased from from $25 up to $350," says ... 100% customer satisfaction and a wide array of skin care ... fees and no expiration dates. , Gift delivery past ...
(Date:12/22/2014)... OAK BROOK, Ill. (PRWEB) December 21, 2014 ... receive radiologist recommendations for chest computed tomography (CT) ... have clinically relevant findings, including cancer, according to ... Radiology. , Researchers said the findings show ... chest X-rays represent valuable contributions to patient care. ...
(Date:12/22/2014)... Phoenix, AZ (PRWEB) December 22, 2014 ... for the absolute best in Arizona home contracting services ... with regard to its quality services in 2014. As ... area since the early 1970s, Parker and Sons is ... ongoing reliability. The company works side-by-side with other top ...
(Date:12/21/2014)... 2014 Weddingshe.com, an outstanding online supplier ... recently released its new selection of Cocktail Dresses for ... according to the newest fashion trends. , ... for cocktail parties . All of them are offered ... We are making every effort to offer a nice ...
(Date:12/21/2014)... Coral Gables, FL (PRWEB) December 21, 2014 ... of head lice, who do they call? The new answer ... Leon Blvd, Coral Gables FL 33134, their newest treatment center ... eradicate this pest quickly, conveniently and without the use of ... Grand Opening is scheduled for January 1, 2015. Like the ...
Breaking Medicine News(10 mins):Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 2Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 3Health News:Stunning Cocktail Party Dresses from Weddingshe.com 2Health News:All-Natural Florida Lice Removal Company Opens New Lice Treatment Salon In South Florida 2
... researcher has discovered an association between foie gras prepared ... amyloid found in rheumatoid arthritis or tuberculosis. ,Dr. ... Tennessee Graduate School of Medicine in Knoxville, says that ... first evidence that a food product can hasten amyloid ...
... PLoS Medicine shows that men can help avoid fractures ... fractures are common among older people and can have devastating ... recommended that women should take exercise to reduce the ... with age is known as osteoporosis. Women are at particular ...
... antigen (PSA) testing continues to be problematic. Even though ... reduce death, illness or disability from prostate cancer, testing ... ,A recent nation-wide survey indicates almost half of Canadian ... lifetime. In this review, Drs. Ian Thompson and Donna ...
... government Tuesday enforced a ban on the use of plastic ... heavy rains the day before flooded Guwahati, throwing the ... ,"The decision to ban the use of plastic and polythene ... logging. The ban would be enforced very strictly and there ...
... medication administered to heart attack or stroke victims to ... reduce the risk of amputation, according to a study ... of critical care has grown significantly in the ... for combating frostbite, say the authors of the article ...
... support film/television actress Fran Drescher's cancer organisation . The ... her Cancer Schmancer organisation. ,'Angelina is supporting ... Jolie's mum actress Marcheline Bertrand fought a cancer battle ... ,Drescher, a cancer survivor, whose disease was diagnosed at ...
Cached Medicine News:Health News:Scientists Establish Link Between Foie Gras and Disease 2Health News:Exercise Reduces Fracture in Men 2Health News:Frostbite can Be Treated by Bloodclot Drug 2
(Date:12/22/2014)... 2014  Relmada Therapeutics, Inc. (OTCQB: RLMD), a ... of chronic pain, announced today that the first ... pharmacokinetic and pharmacodynamic study with d-Methadone, the company,s ... Racemic methadone is a long-acting opioid used ... substitution therapy in opioid addiction.  It is constituted ...
(Date:12/19/2014)... IRVINE, Calif. , Dec. 19, 2014 /PRNewswire/ ... today that Siddhartha Kadia, Ph.D. has joined the ... and Chief Executive Officer and a director of ... high-precision laboratory testing, evaluation and analytical services to ... Prior to joining Evans Analytical Group, ...
(Date:12/19/2014)... Dec. 19, 2014   Hospira, Inc. (NYSE: ... injectable drugs and infusion technologies, today announced that the ... Healthcare Conference on Wednesday, Jan. 14, 2015, in ... to begin at 10:30 a.m. Pacific time on Wednesday, ... interested parties through a live audiocast accessible via the ...
Breaking Medicine Technology:Relmada Therapeutics Doses First Cohort of Subjects in Human Clinical Trial of d-Methadone 2Relmada Therapeutics Doses First Cohort of Subjects in Human Clinical Trial of d-Methadone 3Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2
... ... December 2 DermaGen AB - part of the,Karolinska Development ... AB has received promising results from a,clinical Phase I/IIa study. ... atopic dermatitis. Atopic dermatitis is a chronic,inflammatory skin disease where ...
... , ROCKVILLE, Md., Dec. 2 Novavax, Inc. (Nasdaq: ... first stage of a two-stage pivotal Phase II study evaluating ... particle (VLP) pandemic influenza vaccine. Novavax is conducting this ... registration of the vaccine in Mexico and potentially other countries. ...
Cached Medicine Technology:Dermagen Reports Successful Phase I/IIa Clinical Trial for Atopic Dermatitis 2Dermagen Reports Successful Phase I/IIa Clinical Trial for Atopic Dermatitis 3Dermagen Reports Successful Phase I/IIa Clinical Trial for Atopic Dermatitis 4NOVAVAX Reports Positive Clinical Results from Pivotal Study of H1N1 Influenza Vaccine in Mexico 2NOVAVAX Reports Positive Clinical Results from Pivotal Study of H1N1 Influenza Vaccine in Mexico 3NOVAVAX Reports Positive Clinical Results from Pivotal Study of H1N1 Influenza Vaccine in Mexico 4
... (gadopentetate dimeglumine) injection was introduced in 1988, ... contrast-enhanced magnetic resonance imaging (MRI). It became ... in MRI. Today, the product is still ... head, neck and body. MAGNEVIST is used ...
... injection is a nonionic, iodinated, low-osmolar ... Introduced in the U.S. in 1995, ... Europe, ULTRAVIST today is used ... established a positive clinical experience in ...
The Pinn-ACL Guide can be used to create tibial tunnels of known lengths with a variable angle adjustment of 35 to 60 degrees with the use of a,graduated pin-sleeve....
Forceps with round handle, straight...
Medicine Products: