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Study shows long-term success rates for eradication of Barrett's esophagus after endoluminal therapies
Date:2/12/2013

erved recurrence of dysplasia or cancer. However, recurrence of intestinal metaplasia occurs in one-third of cases, therefore persistent vigilant surveillance is required."

Endoluminal Therapies

Endoscopic therapy may include removal of Barrett's with dysplasia using endoscopic mucosal resection, which removes abnormal tissue in the esophagus without damaging the rest of the esophagus. Endoscopic ablation of Barrett's tissue can be done with either radiofrequency ablation, which destroys and kills cells by heating them, or cryotherapy, which destroys cells by freezing them. After either treatment, the esophagus grows back a normal healthy lining.

Methods

Endoluminal therapy is an option for selected patients with Barrett's esophagus and high-grade dysplasia or early cancer. In this study, researchers sought to assess long-term outcomes of patients treated with endoluminal therapy with the goal of complete eradication of all dysplasia and intestinal metaplasia. This was a retrospective cohort study of selected patients referred with dysplastic Barrett's esophagus at the Hospital of the University of Pennsylvania between January 1998 and December 2009. Patients received endoluminal therapy combining resection and photodynamic therapy, radiofrequency ablation, and/or argon plasma coagulation treatment that was individualized based on patient and lesion characteristics, technique evolution and interval response. Complete eradication of dysplasia, all intestinal metaplasia, and recurrences was assessed.

Results

A total of 166 patients were treated and had at least one year of follow-up. Complete elimination of neoplasia (abnormal cells) was achieved in 157 patients (95 percent) and complete elimination of intestinal metaplasia was achieved in 137 patients (83 percent). After therapy, patients were followed for 33 (range 18-58) months. Among patients who achieved complete elimination of intestinal metaplasia,
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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