Navigation Links
Study shows large-scale genomic testing feasible, impacts therapy
Date:11/15/2012

DENVER Targeted cancer therapy has been transforming the care of patients with non-small-cell lung cancer (NSCLC). It is now standard practice for tumor specimens from NSCLC patients to be examined for EGFR mutations and ALK rearrangements to identify patients for therapy with EGFR and ALK inhibitors, respectively. Now, researchers say large-scale genomic testing is feasible within the clinical workflow, impacting therapeutic decisions. The study is published in the December 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology.

Researchers from the Lowe Center for Thoracic Oncology at the Dana-Farber Cancer Institute, in conjunction with the Center for Advanced Molecular Diagnostics in the Pathology Department at the Brigham and Women's Hospital and the Laboratory for Molecular Medicine at the Partners Healthcare Center for Personalized Genetic Medicine, introduced prospective genotyping of advanced NSCLC for somatic alterations in BRAF, HER2, PIK3CA, and ALK in July 2009, in addition to routine mutational analysis of EGFR and KRAS, which had been ongoing since 2004. Three-hundred forty-four specimens taken from 419 patients were successfully genotyped with a median turnaround time of 31 days.

"The goals of the genomic characterization of our NSCLC patients are to help guide therapy and ultimately lead to improved outcomes for those patients with specific genomic changes," the authors say. "As the repertoire of mutations for which targeted therapy may be offered expands in lung cancer and other solid malignancies, strategies to enable rapid, accurate and comprehensive clinical genotyping will be essential to successfully integrate tumor molecular analysis into the fast pace of clinical decision making and yield its greatest potential impact on patient management."


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related medicine news :

1. Study shows bone metastases treatment can improve overall survival
2. Authors of landmark study on infant mortality and electronic medical records receive Garfield Award
3. Study Tracks Brain Gene Response to Territorial Aggression
4. Study shows different approach after progression in non-small cell lung cancer patients
5. Study reveals insights that could aid in therapeutic use of mesenchymal stem cells
6. Alcoholic Drinks Add 100 Calories a Day to Average Adults Diet: Study
7. Cash cuts increase smoking death risk for worlds poor, study says
8. Study finds asthma is not linked to lower educational attainment
9. RSV study shows potential for vaccine strategies to protect babies
10. Lyme Rash Reappearance Probably Signals New Infection, Study Says
11. Study finds reformulated ER Oxycodone abuse rates are significantly lower than original ER Oxycodone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/18/2017)... (PRWEB) , ... July 18, 2017 , ... ... device compliance and commercialization, has just announced two more sessions of its “From ... engineering into risk management activities. Led by David Cronin, Cognition’s CEO, the half-hour ...
(Date:7/18/2017)... ... July 18, 2017 , ... The results of an international clinical trial, led in ... for a severe type of muscular dystrophy holds promise for a subgroup of patients. , ... McDonald and colleagues at 53 study sites in 18 countries describe the clinical benefit ...
(Date:7/18/2017)... ... July 18, 2017 , ... An inventor from Anacortes, ... "Due to menopause, I have frequent hot flashes, and I suffer from anxiety and ... way to keep cool while out and about." INSTA-FAN meets that need. , This ...
(Date:7/18/2017)... ... July 18, 2017 , ... Heritage Woods of Benton, a ... to 12:30 p.m. on Aug. 15. , The community, which is located at 1305 ... Medicaid, who need some help to maintain their independence. , The lunch menu will ...
(Date:7/18/2017)... ... 18, 2017 , ... FCPX LUT Berlin for Final Cut Pro X gives ... includes 60 different color-grade presets, giving FCPX users numerous options for adding different color ... each subject, plus much more. FCPX LUT Berlin is designed for any skill-level, from ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... , July 12, 2017 CarpalAID is a revolutionary new ... or surgery. Carpal tunnel syndrome affects more than 8 ... twice the rate of men. The common methods of treating CTS ... with uncomfortable hand braces or gloves. ... CarpalAID is a clear patch worn ...
(Date:7/11/2017)... 11, 2017  Sysmex America, Inc., a leading ... equipment as well as middleware information systems technology, ... make quality assurance easier and more risk free ... known for the innovation that it delivers to ... quality assurance processes to a new level with ...
(Date:7/10/2017)...  BDI Group subsidiary Pathway Purchasing Network, a ... serving specialty pharmacies, home infusion companies and physician ... value-added member programs designed to help organizations gain ... improve access and affordability for patients who rely ... Pathway has worked with ...
Breaking Medicine Technology: