Navigation Links
Study shows large-scale genomic testing feasible, impacts therapy
Date:11/15/2012

DENVER Targeted cancer therapy has been transforming the care of patients with non-small-cell lung cancer (NSCLC). It is now standard practice for tumor specimens from NSCLC patients to be examined for EGFR mutations and ALK rearrangements to identify patients for therapy with EGFR and ALK inhibitors, respectively. Now, researchers say large-scale genomic testing is feasible within the clinical workflow, impacting therapeutic decisions. The study is published in the December 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology.

Researchers from the Lowe Center for Thoracic Oncology at the Dana-Farber Cancer Institute, in conjunction with the Center for Advanced Molecular Diagnostics in the Pathology Department at the Brigham and Women's Hospital and the Laboratory for Molecular Medicine at the Partners Healthcare Center for Personalized Genetic Medicine, introduced prospective genotyping of advanced NSCLC for somatic alterations in BRAF, HER2, PIK3CA, and ALK in July 2009, in addition to routine mutational analysis of EGFR and KRAS, which had been ongoing since 2004. Three-hundred forty-four specimens taken from 419 patients were successfully genotyped with a median turnaround time of 31 days.

"The goals of the genomic characterization of our NSCLC patients are to help guide therapy and ultimately lead to improved outcomes for those patients with specific genomic changes," the authors say. "As the repertoire of mutations for which targeted therapy may be offered expands in lung cancer and other solid malignancies, strategies to enable rapid, accurate and comprehensive clinical genotyping will be essential to successfully integrate tumor molecular analysis into the fast pace of clinical decision making and yield its greatest potential impact on patient management."


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related medicine news :

1. Study shows bone metastases treatment can improve overall survival
2. Authors of landmark study on infant mortality and electronic medical records receive Garfield Award
3. Study Tracks Brain Gene Response to Territorial Aggression
4. Study shows different approach after progression in non-small cell lung cancer patients
5. Study reveals insights that could aid in therapeutic use of mesenchymal stem cells
6. Alcoholic Drinks Add 100 Calories a Day to Average Adults Diet: Study
7. Cash cuts increase smoking death risk for worlds poor, study says
8. Study finds asthma is not linked to lower educational attainment
9. RSV study shows potential for vaccine strategies to protect babies
10. Lyme Rash Reappearance Probably Signals New Infection, Study Says
11. Study finds reformulated ER Oxycodone abuse rates are significantly lower than original ER Oxycodone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... (PRWEB) July 26, 2014 The number ... state and federal litigations since the 2012 recall of ... 3,700 filings, Bernstein Liebhard LLP reports. According to a ... 2,064 cases have been filed in the New Jersey’s ... Stem and the ABG II Modular Hip Stem Litigation, ...
(Date:7/26/2014)... (PRWEB) July 26, 2014 As reported ... trends are changing based on 3 factors: smaller spaces, ... several top bathroom trend of 2014 lists, including ... increased popularity. Amerec , a leading manufacturer of ... steam bathing largely due to smaller spaces and an ...
(Date:7/26/2014)... (PRWEB) July 26, 2014 ... recently updated by Vkool.com, this is a ... safe methods for treating all types of ...     Tinnitus due to Ménière's ... ,     Nerve pathway tinnitus , ...
(Date:7/26/2014)... TX (PRWEB) July 26, 2014 ... or encephalomyelitis disseminata, is an inflammatory disease in ... the brain and spinal cord are damaged. This ... nervous system to communicate, resulting in a wide ... and sometimes psychiatric problems. Multiple sclerosis takes several ...
(Date:7/26/2014)... July 26, 2014 Another DePuy Pinnacle hip ... Inc., has been filed by Wright & Schulte LLC. ... on behalf of an Erie County, Ohio man who alleges ... hip and groin since receiving his Pinnacle Hip implant in ... will be forced to undergo a complex and risky revision ...
Breaking Medicine News(10 mins):Health News:Stryker Hip Lawsuit Filings in State and Federal Litigations Continue to Rise, Bernstein Liebhard LLP Reports 2Health News:Stryker Hip Lawsuit Filings in State and Federal Litigations Continue to Rise, Bernstein Liebhard LLP Reports 3Health News:Amerec Finds Bathroom Design Trends Change Based on Water Consumption and Other Factors 2Health News:Tinnitus Miracle Book Review Exposes Thomas Coleman's Guide for Treating Tinnitus – Vkool.com 2Health News:Multiple Sclerosis Therapeutics Clinical Trials Market Review H2 2014 Analysis Report Available at MarketOptimizer.org 2Health News:Multiple Sclerosis Therapeutics Clinical Trials Market Review H2 2014 Analysis Report Available at MarketOptimizer.org 3Health News:Multiple Sclerosis Therapeutics Clinical Trials Market Review H2 2014 Analysis Report Available at MarketOptimizer.org 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Recipient Who Faces Surgery To Replace Artificial Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Recipient Who Faces Surgery To Replace Artificial Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Recipient Who Faces Surgery To Replace Artificial Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Recipient Who Faces Surgery To Replace Artificial Hip Implant 5
... , , BEDFORD, Ohio, July ... announced FDA approval to begin shipping Ceftriaxone for Injection USP. ... Roche. Ceftriaxone is a semisynthetic, broad-spectrum antibiotic used to treat ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20070809/CLTH157LOGO ...
... can greatly influence rotavirus, spread, CDC says , THURSDAY, ... infection, a major cause of infant illness in the ... understanding of when and where infections are likely to ... new research suggests. , A team including scientists from ...
... OAKLAND, Calif., July 16 Arcadian Health announced today that Robert ... the BMO Capital Markets sponsored 9th Annual Focus on Healthcare Conference ... Broadway Hotel. Arcadian is a leading provider of Medicare Advantage health ... and other provider groups. , , ...
... , The hospital is the highest-rated ... , , CHICAGO, July 16 Northwestern ... it the highest ranked in Illinois -- as part of U.S. News & ... authoritative and influential guide evaluated 4,861 medical centers nationwide and 174 were chosen ...
... July 16 The Lewin Group today released ... claims pose in Medicaid managed care. The authors of the report recommend ... used in the Medicare Advantage managed care program. , ... Out-of-Network Payment Stu d y, " was commissioned by ...
... , , , ... AZN ) announced today that it will provide free medication ... under one of the company,s prescription savings programs. , ... for healthcare facilities provides medicines free of charge to community ...
Cached Medicine News:Health News:Bedford Laboratories(TM) to Begin Shipping Ceftriaxone for Injection USP 2Health News:New Insights Could Help Shield Babies From Diarrhea Bug 2Health News:Arcadian Chairman and Chief Executive Officer, Robert Fahlman, to Present at Focus on Healthcare Conference in New York City 2Health News:Northwestern Memorial Among America's Best Hospitals in 11 Clinical Specialties According to U.S. News' 2009 Rankings 2Health News:Northwestern Memorial Among America's Best Hospitals in 11 Clinical Specialties According to U.S. News' 2009 Rankings 3Health News:New Lewin Report Shows Need for National Medicaid Out-of-Network Claims Policy 2Health News:AstraZeneca Partners With Primary Health Care to Help Iowa Uninsured 2Health News:AstraZeneca Partners With Primary Health Care to Help Iowa Uninsured 3
(Date:7/25/2014)... N.C. , July 25, 2014  In today,s ... is costly and challenging - as is managing a ... Is it possible - or even preferable ... If so, where can you combine resources and activities, ... These are just a few of ...
(Date:7/25/2014)... 2014 /PRNewswire-iReach/ -- ScriptPro, of Mission, ... Powers Lake, Wisconsin , announce that they ... co-marketing agreement allowing ScriptPro to bring TCGRx adherence ... the United States . ScriptPro is a ... systems to retail and ambulatory pharmacies. TCGRx distributes ...
(Date:7/25/2014)... Trinidad and Tobago , July 25, 2014 ... the Trinidad & Tobago Ministry of Health approved ... therapy that significantly increases the cure rate from ... infected with the genotype 1 virus. Telaprevir is ... the trade brand INCIVO®. Photo - ...
Breaking Medicine Technology:Using Promotional Efficiency to Support Multiple Products and Indications in the Pharmaceutical Marketplace 2ScriptPro and TCGRx Integrate Pharmacy Automation Technologies 2ScriptPro and TCGRx Integrate Pharmacy Automation Technologies 3The Hepatitis C virus is the main cause of liver transplant in the world 2The Hepatitis C virus is the main cause of liver transplant in the world 3
... Systech International, innovator of Packaging Execution Systems ... leading supplier of end-of-line packaging systems, today announced ... global serialization requirements at Pack Expo 2010 in ... opportunity to examine first hand the actual system ...
... Oct. 27 Alan L. Rubino, former Hoffmann-La Roche ... companies, and Timothy G. Rothwell, former Chairman, CEO, and ... American Therapeutics, Inc.   Mr. Rubino will ... function as the company,s Chairman.  The company,s key emphasis ...
Cached Medicine Technology:Systech and Pester Pac Automation Exhibit Integrated Serialization Solution at Pack Expo 2010 2Veteran Pharmaceutical Executives Form New American Therapeutics, Inc. 2
... Blind Performance Specimens are intended for ... handling and transportation guidelines, including chain ... Testing Programs regulated by the Substance ... (SAMHSA), Health and Human Services Department ...
... Reticulocyte Stain is an aqueous ... use in manual methods of ... has a one year shelf ... and can be used in ...
Seroconversion and Antigen Panel Chart...
... Amplichek CT/GC Controls are ... the precision of test procedures ... Neisseria gonorrhoeae. Since they are ... used with either urine or ...
Medicine Products: