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Study shows how vitamin E can help prevent cancer
Date:3/14/2013

amin E's head group," Chen said. This manipulation enhanced the anti-tumor potency of the molecule by changing its interaction with the cell membrane, so that the head group was more accessible to Akt and PHLPP1.

When mice with tumors created by these two prostate cancer cell lines were injected with the agent, the treatment suppressed tumor growth when compared to a placebo, which had no effect on tumor size. Chemical analysis of the treated tumors showed that the Akt enzyme signal was suppressed, confirming the effects were the same in animals as they had been in cell cultures.

The animal study also suggested the experimental agent was not toxic. Chen's lab is continuing to work on improvements to the molecule.


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Contact: Ching-Shih Chen
chen@pharmacy.ohio-state.edu
614-688-4008
Ohio State University
Source:Eurekalert

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