Navigation Links
Study shows how vitamin E can help prevent cancer
Date:3/14/2013

otent anti-cancer form of the vitamin.

The scientists manipulated the structure of that vitamin E molecule and found that the effectiveness of this new agent they created was 20-fold higher than the vitamin itself in cells. In experiments in mice, this agent reduced the size of prostate cancer tumors.

These findings suggest that an agent based on the chemical structure of one form of vitamin E could help prevent and treat numerous types of cancer particularly those associated with a mutation in the PTEN gene, a fairly common cancer-related genetic defect that keeps Akt active.

The researchers began the work with both alpha and gamma forms of the vitamin E molecule. Both inhibited the enzyme called Akt in very targeted ways, but the gamma structure emerged as the more powerful form of the vitamin.

In effect, the vitamin halted Akt activation by attracting Akt and another protein, called PHLPP1, to the same region of a cell where the vitamin was absorbed: the fat-rich cell membrane. PHLPP1, a tumor suppressor, then launched a chemical reaction that inactivated Akt, rendering it unable to keep cancer cells alive.

"This is a new finding. We have been taking vitamin E for years but nobody really knew about this particular anti-cancer mechanism," Chen said.

The gamma form was most effective because its chemical shape allowed it to attach to Akt in the most precise way to shut off the enzyme.

Because of how the various molecules interacted on the cell membrane, the scientists predicted that shortening a string of chemical groups dangling from the main body, or head group, of the gamma-tocopherol molecule would make those relationships even stronger. They lopped off about 60 percent of this side chain and tested the effects of the new agent in the prostate cancer cells.

"By reducing two-thirds of the chain, the molecule had a 20 times more potent anti-tumor effect, while retaining the integrity of vit
'/>"/>

Contact: Ching-Shih Chen
chen@pharmacy.ohio-state.edu
614-688-4008
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... March 28, 2015 ARDX will sponsor the ... 12pm -3pm at the Chesapeake Conference Center in Chesapeake, Virginia. ... an empowering event for women in the Hampton Roads region. ... Stories of Women’s Lives. Women grow stronger through sharing ... other. This year the WWC™ theme is T-talk where ...
(Date:3/27/2015)... March 27, 2015 Wellness for Cancer–the ... business criteria for the spa and wellness industry–has certified ... who have experienced or are living with cancer. ... Wellness 365® Network, will be identified with a special ... a provider of safe, therapeutic services for cancer patients. ...
(Date:3/27/2015)... Bleeding is one of the ... intervention (PCI), resulting in increased mortality, morbidity, and ... in which the highest-risk PCI patients with the ... often with bleeding avoidance strategies than lower-risk patients. ... Heart Institute asked the question whether prospectively determining ...
(Date:3/27/2015)... The report “CountryFocus Healthcare, Regulatory and ... of information on and analysis of the healthcare, ... elderly population and its associated disease burden are ... the elderly accounted for 27.1% of the total ... Rate (CAGR) of 1.2% to 29.5% in 2020. ...
(Date:3/27/2015)... Michigan (PRWEB) March 27, 2015 ... LiveToBeSober.org, along with former Detroit Lions wide receiver ... luncheon and educational presentation on substance abuse, treatment ... Among those who attended were pastors, ministers and ... leaders and other distinguished guests. , “Our ‘Fighting ...
Breaking Medicine News(10 mins):Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 3Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 4Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2
... , , WOONSOCKET, ... keep Americans healthy this flu season, CVS Caremark today announced its ... The program will include on-site flu clinics at One-Stop Career ... CVS/pharmacy or MinuteClinic. One-Stop Career Centers offer tools and training ...
... , , , N. ... Restylane(R), Perlane(R) and Juvederm(R) are popular for their ability to ... the more sensitive aesthetic patient, the possibility of experiencing injection ... improvement that could be theirs. , , ...
... , , , ... medical technology systems integrator transforming critical care, announced that former Veterans ... Board of Advisors. , , Secretary Peake retired ... and commander in several medical posts culminating in his appointment as ...
... ... in Wyoming, a subsidiary of The Eye Institute of Utah – a prominent ... practice - is the recipient of a national award recognizing the quality of ... in Utah, The Eye Institute’s Rock Springs, Wyoming location has been named by ...
... ... lifelong resident of San Antonio, is on the grow. "Bold moves are made in times ... ... Thom Robey, lifelong resident of San Antonio, is on the grow. "Bold moves are made ...
... have sex with men (MSM) in the township of Soweto in ... infected with HIV. The study,s authors were ... have sex with men in the Soweto Township, an area on ... The researchers found that Soweto MSM identified themselves as ...
Cached Medicine News:Health News:CVS Caremark to Provide $3 Million in Free Flu Shots to the Unemployed 2Health News:CVS Caremark to Provide $3 Million in Free Flu Shots to the Unemployed 3Health News:Painless, Bruise-free Dermal Filler Injections 2Health News:Former Veterans Affairs Secretary Joins Integrated Medical Systems' Advisory Board 2Health News:Former Veterans Affairs Secretary Joins Integrated Medical Systems' Advisory Board 3Health News:The Eye Institute Receives 2009 Best of Rock Springs Award from U.S. Commerce Association 2Health News:The Eye Institute Receives 2009 Best of Rock Springs Award from U.S. Commerce Association 3Health News:REES Announces New San Antonio Office 2Health News:High HIV infection rate among Soweto Township gays 2
(Date:3/27/2015)... , March 27, 2015  Delcath Systems, Inc. ... medical device company focused on oncology with an ... liver cancers, announces the reporting of data from ... Hydrochloride for Injection with the Delcath Hepatic Delivery ... presentation at the Society of Surgical Oncology (SSO) ...
(Date:3/26/2015)... 26, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" ... focus on Omega-3 therapies for cardiovascular disease and overall ... 763,752 common shares of the Corporation (the "Common Shares"). ... period of December 5 th , 2014 to March ... that is due on or before April 1, 2015. ...
(Date:3/26/2015)... 2015 Cardiologists at Beaumont Hospital, ... commercial implant of a device recently approved by the ... fibrillation. The Watchman Left Atrial Appendage Closure implant is ... to reduce the risk of stroke. Atrial ... more than 5 million Americans. Twenty percent of all ...
Breaking Medicine Technology:Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 2Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 3Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 4Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 5Pivotal Therapeutics announces payment of interest on outstanding convertible notes 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 3
... , MOUNTAIN VIEW, Calif., Dec. 14 Alexza Pharmaceuticals, ... submitted its New Drug Application (NDA) for Staccato® loxapine (AZ-004) ... is an inhalation product candidate being developed for the rapid ... The IND for Staccato loxapine was filed ...
... , DENVER, Dec. 14 Corgenix Medical Corporation (OTC ... diagnostic test kits, and BG Medicine, Inc. (BGM), a ... agreement whereby Corgenix will manufacture BGM Galectin-3 diagnostic products ... BG Medicine. BG Medicine is seeking regulatory clearance in ...
Cached Medicine Technology:Alexza Announces Submission of AZ-004 (Staccato(R) Loxapine) NDA 2Alexza Announces Submission of AZ-004 (Staccato(R) Loxapine) NDA 3Alexza Announces Submission of AZ-004 (Staccato(R) Loxapine) NDA 4Alexza Announces Submission of AZ-004 (Staccato(R) Loxapine) NDA 5Alexza Announces Submission of AZ-004 (Staccato(R) Loxapine) NDA 6Corgenix and BG Medicine Announce Supply Agreement for BGM Galectin-3(TM) 2
This design features a solid red iris....
This pattern transform your pupils into narrow slits surrounded by eye stopping yellow. Works well with kitty-cat costumes....
This camouflaging lens features the solid black stripes of the lightning fast African zebra, on a white iris background....
Silicone tip cannula angled at 7 mm, sterile, disposable (bx/10)....
Medicine Products: