Navigation Links
Study shows how to reduce inappropriate shocks from implanted defibrillators
Date:11/7/2012

MAYWOOD, Il. - Loyola University Medical Center is among the centers participating in a landmark study that could lead to fewer inappropriate shocks from implanted defibrillators.

Implanted defibrillators save lives by shocking hearts back into a normal rhythm. But sometimes a defibrillator can go off when it's not necessary, delivering a shock that feels like a kick in the chest.

The study found that reprogramming defibrillators to be less sensitive to irregular heart rhythms reduced the number of inappropriate shocks, while also reducing mortality. The study was presented at a meeting of the American Heart Association Scientific Sessions and is being published in the New England Journal of Medicine.

"Inappropriate shocks can be painful and psychologically traumatic to patients," said cardiologist Dr. Peter Santucci, medical director of Loyola's Implant Device Program. "It's important to reduce these shocks, and results of this study will help us to do this, while also potentially improving patients' survival."

Santucci enrolled Loyola patients in the multi-center international trial. Dr. David Wilber, director of Loyola's Cardiovascular Institute, is a co-author of the paper.

The trial is known as MADIT-RIT (Multicenter Automatic Defibrillator Implantation Trial - Reduce Inappropriate Therapy.) First author is Dr. Arthur J. Moss of the University of Rochester Medical Center.

An implantable cardioverter defibrillator (ICD) is about the size of a pocket watch, and is implanted below the collarbone. Wire leads connect to the heart. The device is designed to protect against tachyarrhythimas -- quivering, superfast heartbeats that prevent the heart from pumping blood effectively.

When the heart goes into a tachyarrhythimia, the ICD's pacemaker is activated. If the pacemaker fails to restore a normal rhythm, the ICD then delivers a powerful electric shock that jolts the heart back into a normal rhythm. But previous research, cited in the new paper, found that ICDs are inappropriately activated in between 8 percent and 40 percent of patients.

Under conventional programming, an ICD may be activated if the heart beats 170 to 199 beats per minute for 2.5 seconds or at least 200 beats per minute for 1 second. If the heart rate does not slow within 5 to 10 seconds, a shock may be delivered.

The study included 1,500 patients, who were randomly assigned to three groups. The first group had ICDs with conventional programming. In the second group, the ICDs would not activate unless the heart beat at least 200 beats per minute. In the third group, the ICDs were programmed to have longer delays before activation (for example, 60 seconds delay when the heart beats 170 to 199 beats per minute).

After an average follow-up of 1.4 years, patients in the second group had a 79 percent reduction in first-time inappropriate ICD activation. Patients in the third group had a 76 percent reduction in first-time inappropriate activation.

There was a 55 percent reduction in deaths in the second group and a 44 percent reduction in deaths in the third group.
'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... Oily skin is a common and unwelcomed occurrence in people of ... a lot to offer to the discussion of dealing with excess skin oil. “Oily skin ... many home remedies that can help remove the oily shine while keeping the skin fresh ...
(Date:3/28/2017)... ... March 28, 2017 , ... “A Prophets Bones”: a thrilling adventure that reveals the ... , “There were things that his parents and teachers had asked of him that he ... he was going to defy the Almighty Creator. There were some who would have felt ...
(Date:3/27/2017)... FL (PRWEB) , ... March 27, 2017 , ... ... new patients for clear braces. People who want straight teeth without the extensive ... Invisalign® in Clearwater, FL, without acquiring a referral. A custom-designed series of ...
(Date:3/27/2017)... ... 2017 , ... Drs. Justin Kolnick, Kara Diamond, Randall Barton, Keith Hope and ... key role this treatment plays in protecting oral health, along with the benefits of ... who need a root canal in White Plains, NY or their second location in ...
(Date:3/27/2017)... (PRWEB) , ... March 27, 2017 , ... A study ... Buckingham MD, and his colleague, Sudeep Roy, MD, was recently published in the ... Electrocautery Efficacy in Rhytidectomy” details Drs. Buckingham and Roy’s study on the use of ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 2017  Sanderling Ventures, portfolio company, Torax Medical, ... of Johnson & Johnson. Torax manufactures and markets the ... gastro-esophageal reflux disease (GERD). The LINK device is ... the procedure is currently available in the U.S. ... was founded by Sanderling Ventures, Mayo Medical Ventures ...
(Date:3/27/2017)... TEL AVIV, Israel , March 27, 2017 ... focused on oncology and immunology, announced today that AGI-134, an ... recently announced acquisition of Agalimmune Ltd., will be featured at ... Meeting in Washington, DC to ... ...
(Date:3/27/2017)... , March 27, 2017 The ... reach USD 16.0 billion by 2025, according to a ... prevalence of chronic diseases is anticipated to be responsible ... which thereby widens the scope for growth during the ... bariatric population, which is highly susceptible to chronic diseases, ...
Breaking Medicine Technology: