Navigation Links
Study shows how the Nanog protein promotes growth of head and neck cancer
Date:6/18/2013

COLUMBUS, Ohio- A study led by researchers at The Ohio State University Comprehensive Cancer Center- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCCJames) has identified a biochemical pathway in cancer stem cells that is essential for promoting head and neck cancer.

The study shows that a protein called Nanog, which is normally active in embryonic stem cells, promotes the growth of cancer stem cells in head and neck cancer. The findings provide information essential for designing novel targeted drugs that might improve the treatment of head and neck cancer.

Normally, Nanog helps healthy embryonic stem cells maintain their undifferentiated, uncommitted (i.e., pluripotent) state. But recent evidence suggests that Nanog promotes tumor growth by stimulating the proliferation of cancer stem cells.

"This study defines a signaling axis that is essential for head and neck cancer progression, and our findings show that this axis may be disrupted at three key steps," says principal investigator Quintin Pan, PhD, associate professor of otolaryngology at the OSUCCC- James. "Targeted drugs that are designed to inhibit any or all of these three steps might greatly improve the treatment of head and neck cancer."

The findings were published in a recent issue of the journal Oncogene.

Specifically, the study shows that an enzyme called "protein kinase C-epsilon" (PKCepsilon) adds energy-packing phosphate groups to the Nanog molecule. This phosphorylation of Nanog stabilizes and activates the molecule.

It also triggers a series of events: Two Nanog molecules bind together, and these are joined by a third "co-activating" molecule called p300. This molecular complex then binds to the promoter region of a gene called Bmi1, an event that increases the expression of the gene. This, in turn, stimulates proliferation of cancer stem cells.

"Our work shows that the PKCepsilon/Nanog/Bmi1 sign
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study identifies protein essential for normal heart function
2. Study finds racial and ethnic disparities in usage of specialty services for children with autism
3. Study Finds Individuals with Arthritis Don’t Walk Enough, Allsup Reports
4. Older patients will make lifestyle changes to avoid fractures, study finds
5. Loopholes in Federally Mandated IVF Reporting Lead Some Clinics to Artificially Inflate IVF Pregnancy Rates, Center for Human Reproduction Study Reports
6. Study Shows Alcohol Abusers Cannot Depend on Their Designated Drivers
7. UF study finds brain-imaging technique can help diagnose movement disorders
8. First major study of suicide motivations to advance prevention
9. Insurance Service Center Discusses a Recent Health Study and Encourages the Wisconsin Community to Purchase Adequate Health Coverage to Avoid a Financial Disaster
10. Study Identifies Most Effective Natural Bed Bug Killer
11. Clearwater, FL Periodontist, Dr. Stephen Kobernick Cites Recent Periodontal Study Urging Patients to Seek Gum Disease Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... Recently, Locks-Magnetic.com , one of ... promotion of mag locks for glass doors online. In ... on these fresh products. Customers can get more information ... doors are in excellent performance. Customers who want to ... soon as possible. They also can enjoy the ...
(Date:11/22/2014)... November 23, 2014 Today, Dylan Queen, ... new collection of wedding dresses; the business offers a ... related accessories for ladies worldwide, allowing them to create ... of the company, this new collection of chic wedding ... Moreover, they are offered at discounted rates now. Dylan ...
(Date:11/22/2014)... “Due to my knee replacement surgery, I ... Ill. “While using the ice grip attachment, I noticed how ... needed to be a safer way to prevent possible injuries, ... The SPIKE BLOCK offers added safety and stability in slick ... reduce injuries and damage associated with traditional spiked ice grips. ...
(Date:11/22/2014)... 22, 2014 In order to provide better ... of cocktail party dresses. The business knows that a suitable ... occasions. , Now, the party dresses supplier’s high ... off. As the leading company in fashion industry, LunaDress understands ... for every customer. So it always raises the professional level ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 "My friend ... pain caused by the machine," said an inventor from ... had to go back a second time because the ... idea." , She developed the patent-pending MAMO EASY to ... cancer. The design saves the patient from the pain ...
Breaking Medicine News(10 mins):Health News:Discounted Mag Locks for Glass Doors Revealed by Locks-Magnetic.com 2Health News:Dylan Queen Introduces Its New Wedding Dresses 2Health News:LunaDress Unveils Fabulous Cocktail Party Dresses 2
... donated over $7 Million for the Jimmy Fund, ... store owners,in New England Monday raised just over ... proceeds generated from the 11th Annual,Dunkin, Donuts George ... by Dunkin, Donuts Northeast Distribution Center (NEDCP),and held ...
... Indulge yourself on a,lazy Sunday with a great meal and ... to unwind., Every Sunday, from 12pm - 4pm, Voda Spa ... Spa,ing and brunching:, Brunch Massage $140 ... $175, Choose from a selection of delicious dishes ...
... is still working in more than 30,earthquake-affected communities ... When the massive,earthquake struck this region last August ... 140,000 people homeless.,Although the spotlight has moved on, ... working with the Peruvian Red Cross to help ...
... scientists have made a breakthrough in understanding how a ... help the body to fight bacterial infections in the ... in Nature Medicine. , Hans-Uwe Simon, ... from the University of Utah School of Medicine, and ...
... Best Medical Spa in America. Raleigh, NC medspa Blue Water Spa owner ... Medspa conference on October 6, 2008 in Orlando, FL. , ... Raleigh, ... has been voted Best Medical Spa in America. Medical Spa Owner Kile ...
... 14-year old founder of The Blue Lion Foundation is raffling her tickets ... and inspire people of all ages to overcome challenges through persistence and ... ... Allen,s father purchased tickets for her to The Jonas Brothers, she decided ...
Cached Medicine News:Health News:Dunkin' Donuts Event Raises $800,000 for Cancer Research in One Day 2Health News:One Year Later: Red Cross Helping Peru Earthquake Survivors Rebuild 2Health News:White blood cell uses DNA 'catapult' to fight infection 2Health News:Medical Spa Consulting from Best Medspa in America to Provide Advanced Medical Spa Education at Medspa Conference in Orlando, FL 2Health News:Medical Spa Consulting from Best Medspa in America to Provide Advanced Medical Spa Education at Medspa Conference in Orlando, FL 3Health News:Pittsburgh Teen Raffles Her Jonas Brothers Tickets to Educate and Inspire 2Health News:Pittsburgh Teen Raffles Her Jonas Brothers Tickets to Educate and Inspire 3
(Date:11/22/2014)... Research and Markets  has announced the addition of the ... report to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... market has been expanding rapidly owing to the improvement ... 2005-2013, sales of recombinant protein drugs available in Chinese ... it is projected that China ...
(Date:11/21/2014)... Nov. 21, 2014  Alere Inc. (NYSE: ... has appointed Juliet Cunningham as Vice President, ... be responsible for driving communications with the investment community. ... series of changes to increase shareholder value, it is ... said Namal Nawana, Chief Executive Officer. "We are delighted ...
(Date:11/21/2014)... and VIENNA, Va. , ... in-home care provider that operates in Southern ... leading provider of remote caregiving technology. Alta will be ... existing client receiving homecare services. Logo - ... technology is the key to providing the kind of ...
Breaking Medicine Technology:China Recombinant Protein Drug Industry Report, 2014-2017 2China Recombinant Protein Drug Industry Report, 2014-2017 3Alere Appoints Juliet Cunningham to Lead Investor Relations 2Alta Home Care, Inc. and BeClose Partner to Enable Seniors to Remain in Their Homes Safely and Securely 2
... identify patients at a high risk for ... events in heart failure patients, TORONTO, Sept. 24 ... Access and Review Trending Information and Evaluate,Correlation to Symptoms ... Annual Scientific Meeting of the Heart Failure Society of ...
... Arpida,Ltd. (SWX: ARPN) today announced the completion of ... oral iclaprim in patients with,complicated Skin and Skin ... as a multi-centre, double-blind comparative,study. Patients suffering from ... days of treatment and were then randomised to ...
Cached Medicine Technology:Can Implantable Devices for Heart Failure Help Assess Risk of Future Adverse Events for Heart Failure Patients? 2Can Implantable Devices for Heart Failure Help Assess Risk of Future Adverse Events for Heart Failure Patients? 3Arpida Completes Enrolment in Phase II "Intravenous-to-Oral" Switch Trial With Oral Iclaprim 2Arpida Completes Enrolment in Phase II "Intravenous-to-Oral" Switch Trial With Oral Iclaprim 3
The Fluoroskan Ascent FL is equipped with both fluorometric and luminometric measurement technologies, providing a full coverage for fluorometric, glow and flash luminometric applications even in the...
FlexStationII offers the highest level of flexibility in developing functional cellular assays and analyzing real time kinetic data....
... The C&L Dye Fluorometer utilizes unique ... the illumination and detection optics. The filter ... emission for numerous types of applications. With ... settle on measuring one or two wavelengths. ...
... The Modulus™ is a ... designed to give you ... fluorescence, luminescence, and absorbance. ... dedicated fluorometer, dedicated luminometer, ...
Medicine Products: