Navigation Links
Study shows how the Nanog protein promotes growth of head and neck cancer
Date:6/18/2013

COLUMBUS, Ohio- A study led by researchers at The Ohio State University Comprehensive Cancer Center- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCCJames) has identified a biochemical pathway in cancer stem cells that is essential for promoting head and neck cancer.

The study shows that a protein called Nanog, which is normally active in embryonic stem cells, promotes the growth of cancer stem cells in head and neck cancer. The findings provide information essential for designing novel targeted drugs that might improve the treatment of head and neck cancer.

Normally, Nanog helps healthy embryonic stem cells maintain their undifferentiated, uncommitted (i.e., pluripotent) state. But recent evidence suggests that Nanog promotes tumor growth by stimulating the proliferation of cancer stem cells.

"This study defines a signaling axis that is essential for head and neck cancer progression, and our findings show that this axis may be disrupted at three key steps," says principal investigator Quintin Pan, PhD, associate professor of otolaryngology at the OSUCCC- James. "Targeted drugs that are designed to inhibit any or all of these three steps might greatly improve the treatment of head and neck cancer."

The findings were published in a recent issue of the journal Oncogene.

Specifically, the study shows that an enzyme called "protein kinase C-epsilon" (PKCepsilon) adds energy-packing phosphate groups to the Nanog molecule. This phosphorylation of Nanog stabilizes and activates the molecule.

It also triggers a series of events: Two Nanog molecules bind together, and these are joined by a third "co-activating" molecule called p300. This molecular complex then binds to the promoter region of a gene called Bmi1, an event that increases the expression of the gene. This, in turn, stimulates proliferation of cancer stem cells.

"Our work shows that the PKCepsilon/Nanog/Bmi1 signaling axis is essential to promote head and neck cancer," Pan says. "And it provides initial evidence that the development of inhibitors that block critical points in this axis might yield a potent collection of targeted anti-cancer therapeutics that could be valuable for the treatment of head and neck cancer."


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Study identifies protein essential for normal heart function
2. Study finds racial and ethnic disparities in usage of specialty services for children with autism
3. Study Finds Individuals with Arthritis Don’t Walk Enough, Allsup Reports
4. Older patients will make lifestyle changes to avoid fractures, study finds
5. Loopholes in Federally Mandated IVF Reporting Lead Some Clinics to Artificially Inflate IVF Pregnancy Rates, Center for Human Reproduction Study Reports
6. Study Shows Alcohol Abusers Cannot Depend on Their Designated Drivers
7. UF study finds brain-imaging technique can help diagnose movement disorders
8. First major study of suicide motivations to advance prevention
9. Insurance Service Center Discusses a Recent Health Study and Encourages the Wisconsin Community to Purchase Adequate Health Coverage to Avoid a Financial Disaster
10. Study Identifies Most Effective Natural Bed Bug Killer
11. Clearwater, FL Periodontist, Dr. Stephen Kobernick Cites Recent Periodontal Study Urging Patients to Seek Gum Disease Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: