Navigation Links
Study shows how the Nanog protein promotes growth of head and neck cancer
Date:6/18/2013

COLUMBUS, Ohio- A study led by researchers at The Ohio State University Comprehensive Cancer Center- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCCJames) has identified a biochemical pathway in cancer stem cells that is essential for promoting head and neck cancer.

The study shows that a protein called Nanog, which is normally active in embryonic stem cells, promotes the growth of cancer stem cells in head and neck cancer. The findings provide information essential for designing novel targeted drugs that might improve the treatment of head and neck cancer.

Normally, Nanog helps healthy embryonic stem cells maintain their undifferentiated, uncommitted (i.e., pluripotent) state. But recent evidence suggests that Nanog promotes tumor growth by stimulating the proliferation of cancer stem cells.

"This study defines a signaling axis that is essential for head and neck cancer progression, and our findings show that this axis may be disrupted at three key steps," says principal investigator Quintin Pan, PhD, associate professor of otolaryngology at the OSUCCC- James. "Targeted drugs that are designed to inhibit any or all of these three steps might greatly improve the treatment of head and neck cancer."

The findings were published in a recent issue of the journal Oncogene.

Specifically, the study shows that an enzyme called "protein kinase C-epsilon" (PKCepsilon) adds energy-packing phosphate groups to the Nanog molecule. This phosphorylation of Nanog stabilizes and activates the molecule.

It also triggers a series of events: Two Nanog molecules bind together, and these are joined by a third "co-activating" molecule called p300. This molecular complex then binds to the promoter region of a gene called Bmi1, an event that increases the expression of the gene. This, in turn, stimulates proliferation of cancer stem cells.

"Our work shows that the PKCepsilon/Nanog/Bmi1 sign
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study identifies protein essential for normal heart function
2. Study finds racial and ethnic disparities in usage of specialty services for children with autism
3. Study Finds Individuals with Arthritis Don’t Walk Enough, Allsup Reports
4. Older patients will make lifestyle changes to avoid fractures, study finds
5. Loopholes in Federally Mandated IVF Reporting Lead Some Clinics to Artificially Inflate IVF Pregnancy Rates, Center for Human Reproduction Study Reports
6. Study Shows Alcohol Abusers Cannot Depend on Their Designated Drivers
7. UF study finds brain-imaging technique can help diagnose movement disorders
8. First major study of suicide motivations to advance prevention
9. Insurance Service Center Discusses a Recent Health Study and Encourages the Wisconsin Community to Purchase Adequate Health Coverage to Avoid a Financial Disaster
10. Study Identifies Most Effective Natural Bed Bug Killer
11. Clearwater, FL Periodontist, Dr. Stephen Kobernick Cites Recent Periodontal Study Urging Patients to Seek Gum Disease Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... In the United States alone, an estimated 23.5 ... an illicit drug or alcohol problem in ... Services Administration’s Survey on Drug Use and Health (published ... stories of men and women whose lives have been ... Kerr , founder and retired president of the nationally ...
(Date:4/25/2015)... April 25, 2015 Carinsurancequotesinfo.com has released ... low cost auto insurance for flatbed trucks. ... goods and sometimes other vehicles. They are mainly used ... The newly released blog post explains that by comparing ... trucks, vans and other commercial vehicles. , It is ...
(Date:4/25/2015)... April 25, 2015 The impact of ... eliciting the excitement of the public and is likely ... months of May and June. From March 21st ... biannual tradition of "Special Prayers." More than 600 people ... previous Special Prayers and have reported intense experiences that ...
(Date:4/25/2015)... 25, 2015 Gardant Management Solutions ... management and operations, and sales and marketing at ... scheduled to be held from April 29 through ... is the largest eldercare association in Illinois. The ... for older adults, including senior housing, assisted living ...
(Date:4/25/2015)... The URO CENTER of NEW YORK is pleased ... the New York Academy of Medicine to receive the prestigious ... of Urology. , Dr. Ferdinand Valentine, born in 1851, was ... He was a man of rare and attractive personality who ... only did he devote his life to his profession and ...
Breaking Medicine News(10 mins):Health News:New Book Features Powerful Stories of People Who Overcame Addiction 2Health News:New Book Features Powerful Stories of People Who Overcame Addiction 3Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 2Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 3Health News:Gardant Management Solutions Staff Shares Operational Expertise 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3
... Month, Mobile Dental Clinic to Visit Delaware,Philadelphia, and Southern New ... to Area ... 2 The St. Christopher,s,Foundation for Children Ronald McDonald Care ... National Dental Hygiene Month,(October). The tour will include stops at ...
... as Growth Platform, NEW YORK, and MADISON, ... private investment firm, announced today that,it has acquired ... of personal protective equipment, safety equipment, first aid,supplies, ... Corporation.,The transaction has a value of approximately $48 ...
... Diego, October 2, 2007 Do young adults learn ... November issue of the American Journal of Preventive Medicine, ... the relationship between young adults (age 18-25) observing smoking ... They found that more exposure to smoking in movies ...
... America, a subsidiary of Essilor International, has acquired ... polarized lens distributors in the United,States. Created ... generates sales,of around $31 million. A recognized specialist ... it supplies retail chains and eye care,professionals with ...
... it comes to preventing cancer, women believe they,re doing more ... more afraid of getting Alzheimer,s disease than cancer, even though ... These are among the new findings of a national opinion ... Center and Prevention of 800 women between the ages of ...
... 1 House Republican Whip Roy,Blunt (Mo.) urged Democratic ... work with Republicans on crafting a real,meaningful bill to ... health care., "If Democrats are serious about extending ... to start working with House,Republicans to craft a bill ...
Cached Medicine News:Health News:St. Christopher's Foundation For Children Ronald McDonald(R) Care Mobile Making Tri-State Visits to Provide Dental Care to Children at No Cost 2Health News:Caxton-Iseman Capital Acquires Conney Safety Products, LLC 2Health News:M. D. Anderson-Prevention poll finds women can do more to prevent cancer...but aren't 2Health News:M. D. Anderson-Prevention poll finds women can do more to prevent cancer...but aren't 3
(Date:4/24/2015)... Allowing more basic emergency medical service (EMS) staff to ... opioids, according to a Centers for Disease Control and ... Medical Service Providers and the Burden of Drug Overdose ... of Public Health . In 2013, more ... involved prescription opioids, and more than 8,000 ...
(Date:4/24/2015)... 24, 2015 In today,s ever-changing and ... around the world to access diverse skill sets, ... there are many areas to misstep in the ... best practices are necessary and beneficial in order ... According to research by benchmarking firm, Best Practices, ...
(Date:4/24/2015)... , Apr. 24, 2015 Research and ... announced the addition of the "Lab ... tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station) & End User ... Global Forecast to 2020" report to ... accessories market is expected to reach $504.7 ...
Breaking Medicine Technology:Expanding Naloxone use could reduce drug overdose deaths and save lives 2Expanding Naloxone use could reduce drug overdose deaths and save lives 3Work Around the Clock: Building Effective Global Capabilities 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 3
... SILVER SPRING, Md., May 13, 2011 The U.S. Food ... represented as "ExtenZe," which is the name of an authentic ... similar to the actual product, but contains hidden ingredients that ... the following lot numbers on the packages: ...
... 13, 2011 Amnis Corporation, a manufacturer of advanced ... new FlowSight imaging flow cytometer. The FlowSight ... unrivalled fluorescence sensitivity and the breakthrough ability to produce ... upgraded in the factory or the field with up ...
Cached Medicine Technology:FDA Warns About Counterfeit ExtenZe Dietary Supplements 2
Created to simplify stereopsis screening in children. Based on principles of random dots. No glasses are necessary for this stereo test, and the child's eye movement can be easily observed....
... to diagnose Stereo and Binocular vision in children ... glasses. The test can be used for testing ... and depth perception. The Stereo Cube tests for ... arc and is ideal for optometric examinations as ...
... was created to simplify stereopsis screening in children. ... and cylindrical gratings. Lang Stereotest II measures disparities: ... elephant 600 seconds of arc plus monocularly visible ... random dots are smaller and less dense. This ...
... tests provide accurate measurement of stereopsis. ... of polarized glasses. The original comes ... into a thin plastic frame with ... Richmonds new P/N 4465 Polycarbonate polarized ...
Medicine Products: