Navigation Links
Study shows how the Nanog protein promotes growth of head and neck cancer
Date:6/18/2013

COLUMBUS, Ohio- A study led by researchers at The Ohio State University Comprehensive Cancer Center- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCCJames) has identified a biochemical pathway in cancer stem cells that is essential for promoting head and neck cancer.

The study shows that a protein called Nanog, which is normally active in embryonic stem cells, promotes the growth of cancer stem cells in head and neck cancer. The findings provide information essential for designing novel targeted drugs that might improve the treatment of head and neck cancer.

Normally, Nanog helps healthy embryonic stem cells maintain their undifferentiated, uncommitted (i.e., pluripotent) state. But recent evidence suggests that Nanog promotes tumor growth by stimulating the proliferation of cancer stem cells.

"This study defines a signaling axis that is essential for head and neck cancer progression, and our findings show that this axis may be disrupted at three key steps," says principal investigator Quintin Pan, PhD, associate professor of otolaryngology at the OSUCCC- James. "Targeted drugs that are designed to inhibit any or all of these three steps might greatly improve the treatment of head and neck cancer."

The findings were published in a recent issue of the journal Oncogene.

Specifically, the study shows that an enzyme called "protein kinase C-epsilon" (PKCepsilon) adds energy-packing phosphate groups to the Nanog molecule. This phosphorylation of Nanog stabilizes and activates the molecule.

It also triggers a series of events: Two Nanog molecules bind together, and these are joined by a third "co-activating" molecule called p300. This molecular complex then binds to the promoter region of a gene called Bmi1, an event that increases the expression of the gene. This, in turn, stimulates proliferation of cancer stem cells.

"Our work shows that the PKCepsilon/Nanog/Bmi1 sign
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study identifies protein essential for normal heart function
2. Study finds racial and ethnic disparities in usage of specialty services for children with autism
3. Study Finds Individuals with Arthritis Don’t Walk Enough, Allsup Reports
4. Older patients will make lifestyle changes to avoid fractures, study finds
5. Loopholes in Federally Mandated IVF Reporting Lead Some Clinics to Artificially Inflate IVF Pregnancy Rates, Center for Human Reproduction Study Reports
6. Study Shows Alcohol Abusers Cannot Depend on Their Designated Drivers
7. UF study finds brain-imaging technique can help diagnose movement disorders
8. First major study of suicide motivations to advance prevention
9. Insurance Service Center Discusses a Recent Health Study and Encourages the Wisconsin Community to Purchase Adequate Health Coverage to Avoid a Financial Disaster
10. Study Identifies Most Effective Natural Bed Bug Killer
11. Clearwater, FL Periodontist, Dr. Stephen Kobernick Cites Recent Periodontal Study Urging Patients to Seek Gum Disease Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... Recently, VogueQueen.com, a leading wedding dress wholesaler ... Online for 2015. Great discounts are now offered ... consumers can get a discount, up to 80% off, ... before January 30, 2015. , VogueQueen.com has recently released ... prom dress promotion. Many customers worldwide like VogueQueen’s special ...
(Date:12/20/2014)... Angeldress.co.uk, the distinguished wedding dress manufacturer ... dress fans. The company has recently updated its official ... the holiday season, Angeldress Blog has recommended ... , Angeldress.co.uk prides itself in offering a huge selection ... All the company’s outfits are very carefully selected based ...
(Date:12/20/2014)... Atore, Inc, (San Francisco, CA CEO: Masashi ... focused portal on December 17th, 2014. , One ... US and Japan. , MERRY BIRTHDAY SITE : ... , MERRY BIRTHDAY MESSAGE is part of 5 future ... Features, Choose from thousands of stock photos to decorate ...
(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer ... coming Christmas. In the promotion, all buyers worldwide can ... have something special for the women who are looking ... our new collections of 2015 dresses have been unveiled ... greatly discounted prices. Visit our website now before they ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 Xarelto ... they suffered uncontrollable bleeding and other serious side ... Eastern District of Louisiana for coordinated pretrial proceedings, Wright ... Multidistrict Litigation (JPML) issued an order Friday to transfer ... pending in 22 federal courts to the Louisiana district ...
Breaking Medicine News(10 mins):Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2Health News:Atore, Inc. Releasing the First Birthday Portal 2Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4
... to therapeutic applications in humans, researchers say ... neurons derived from reprogrammed adult skin cells successfully ... reduced symptoms of a Parkinson,s disease-like condition in ... the first demonstration that reprogrammed cells can integrate ...
... 7, 2008 , WHEN: Lecture: Thursday, April 10, 2008 from 1:30 ... interviews with spokespeople available before and ... to schedule., WHERE: The University of Texas at Austin ... 2405 Robert Dedman Drive ...
... new study says , , MONDAY, April 7 (HealthDay News) ... drugs, accidental overdoses and unfavorable reactions -- affect about ... study says. , That figure is much higher than ... errors involving hospitalized children -- an issue that generated ...
... 2008 Looking for new,ideas for a Mother,s Day ... Day MiniWeek from May 11 - 15, 2008, Deerfield ... everyone in their,party, and offering complimentary make-up applications prior ... will receive $200 each,towards spa services during their stay., ...
... Stronger than anticipated,revenues for flu vaccines, and the surprising ... cervical cancers, has led to a healthy,$16.3 billion in ... 38%,over 2006 sales of $11.7 billion, according to Vaccines ... a Fast-Changing Industry, a,new market research study and reforecast ...
... April 7, 2008 Forest Laboratories,Inc. (NYSE: ... products, will release its Fiscal 2008 Fourth Quarter,financial ... Tuesday, April 15,2008. Later that day, at 10:00 ... Dr. Lawrence Olanoff, President and Chief Operating Officer ...
Cached Medicine News:Health News:Reprogrammed Cells Reduce Parkinson's Symptoms 2Health News:Childhood Obesity Expert Dr. William Dietz Featured at the 2nd Annual Michael & Susan Dell Lectureship in Child Health 2Health News:Childhood Obesity Expert Dr. William Dietz Featured at the 2nd Annual Michael & Susan Dell Lectureship in Child Health 3Health News:Childhood Obesity Expert Dr. William Dietz Featured at the 2nd Annual Michael & Susan Dell Lectureship in Child Health 4Health News:Drug Mix-Ups Harm Hospitalized Kids 2Health News:Drug Mix-Ups Harm Hospitalized Kids 3Health News:Mother's Day Gifts from Deerfield Spa Give Moms What They Love Most ... Photographs and Memories 2Health News:Gardasil, Other New Products Spur Strong Vaccine Sales in 2007 2Health News:Forest Laboratories, Inc. Sets Date and Conference Call for Fiscal 2008 Fourth Quarter Earnings 2
(Date:12/19/2014)... 19, 2014  Advanced Medical Isotope Corporation ("AMIC") ... primarily in the development of brachytherapy devices and ... announced that a Life Sciences Discovery Fund (LSDF) ... which AMIC is the commercialization partner.  The award ... the proposal titled "Optimized Injectable Radiogels for High-dose ...
(Date:12/19/2014)... WESTMINSTER, Colo. , Dec. 19, 2014  Monarch ... (f/k/a Cannabis Kinetics Corp.) is pleased to provide this ... for continued growth in 2015. "Over this ... corporate goals and I am extremely proud to say ... diversified position today than it has ever been," stated ...
(Date:12/19/2014)... , Dec. 18, 2014  Sage Analytics ... generation of equipment for the testing of marijuana ... of the new Luminary™ Profiler, the industry,s first ... measurement in a cost-effective, portable unit. ... specific needs of the cannabis industry, the Luminary™ ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 2Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 3Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... symptom control ... with combination therapy ... published study presents,data demonstrating that patients with Chronic Obstructive ... bronchodilation and symptom control when treated with a,combination of ...
... a Benefit,of Anti-Tumor Necrosis Factor Therapies on Absenteeism Among Employees with ... ... a new analysis of the,Active Ulcerative Colitis Trials (ACT 1 and ... patients with moderately to severely active,ulcerative colitis (UC) receiving REMICADE(R) (infliximab) ...
Cached Medicine Technology:Concomitant Treatment With Nebulized Formoterol Fumarate and Tiotropium Provides Clinically Significant Improvements for COPD Patients 2Concomitant Treatment With Nebulized Formoterol Fumarate and Tiotropium Provides Clinically Significant Improvements for COPD Patients 3Concomitant Treatment With Nebulized Formoterol Fumarate and Tiotropium Provides Clinically Significant Improvements for COPD Patients 4Concomitant Treatment With Nebulized Formoterol Fumarate and Tiotropium Provides Clinically Significant Improvements for COPD Patients 5Concomitant Treatment With Nebulized Formoterol Fumarate and Tiotropium Provides Clinically Significant Improvements for COPD Patients 6Concomitant Treatment With Nebulized Formoterol Fumarate and Tiotropium Provides Clinically Significant Improvements for COPD Patients 7New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 2New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 3New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 4New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 5New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 6New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 7New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease 8
... tip is specially rounded, extra ... wound and manipulation in the ... flexible tubing 25cm, ID - ... annular rings start .85mm ...
For administering anesthetic agents into the posterior sub-Tenon's space 20G x 1in (.90 x 25mm)...
... This all digital single plane C-arm angiography ... cardiac imaging performance and an expansive range ... cardiac angiography to ECG triggered. ... Detector technology,State of the art dynamic Flat ...
For diagnostic and operative treatment of hand and wrist bones. The use of this distraction device allows fracture reduction or widening of the space between bones....
Medicine Products: