Navigation Links
Study shows how streptococcal bacteria can be used to fight colon cancer
Date:5/20/2014

Researchers at Western University (London, Canada) have shown how the bacteria primarily responsible for causing strep throat can be used to fight colon cancer. By engineering a streptococcal bacterial toxin to attach itself to tumour cells, they are forcing the immune system to recognize and attack the cancer.

Kelcey Patterson, a PhD Candidate at Western and the lead author on the study, showed that the engineered bacterial toxin could significantly reduce the size of human colon cancer tumours in mice, with a drastic reduction in the instances of metastasis. By using mouse models that are stripped of their immune system, they were able to create a 'humanized mouse' one that would not only grow human colon cancer cells, but would also support a human immune system, to test the anti-cancer immunotherapy.

The work was directed by John McCormick, PhD, an Associate Professor in the Department of Microbiology and Immunology and Scientist at the Lawson Health Research Institute. "Our team has been studying these bacterial toxins called 'superantigens' for their role in bacterial infections. But we are now utilizing the power of these toxins to re-direct the immune system to go after cancer cells." McCormick says their research provides important pre-clinical evidence that this may work in humans. "This work represents a 'next-generation immunotoxin' that we hope will eventually lead to a new class of cancer therapeutic."

The research was funded by the Canadian Institutes of Health Research. Jennifer Dixon Pittaro, Peter Bastedo, David Hess and Mansour Haeryfar all contributed to the paper entitled "Control of established colon cancer xenografts using a novel humanized single chain antibody-streptococcal superantigen fusion protein targeting the 5T4 oncofetal antigen."

McCormick and his colleagues have now received a new grant from the Cancer Research Society to develop different toxin and antibody combinations to fight other types of cancer.


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert  

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study shows how streptococcal bacteria can be used to fight colon cancer
(Date:12/5/2016)... ... December 05, 2016 , ... ... the 21st Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and ... Talamo said, “We are honored to have Amy E. Herman present at this ...
(Date:12/5/2016)... ... December 05, 2016 , ... Dr. Barry M. Weintraub, one of New ... recently participated in the 36th Annual Cutting Edge Aesthetic Symposium at the Waldorf Astoria ... getting that perfect, yet natural-looking, nose. Dr. Weintraub, who is world-renowned for his expertise ...
(Date:12/5/2016)... MALVERN, PA (PRWEB) , ... ... ... Management ("CSM"), a Great Point Partners ("GPP") portfolio company, today announced it ... Clinical Supplies ("TCS"). TCS was previously a subsidiary of Chiltern International ...
(Date:12/5/2016)... ... ... Shah MD, MBA has joined the Retina Group of New York (RGONY) specializing ... M. Maisel, MD and has been providing tertiary medical and surgical retinal care on Long ... expectations amongst her peers. Growing up in a family of doctors, Dr. Shah emulated ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... the 2016 Anti-Aging & Beauty Awards at The Aesthetic & Anti-aging Medicine ... Medicine European Congress (AMEC) brings together the industry’s leading scientific experts, speakers, ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... PUNE, India , December 5, 2016 ... Market by Product Type and by Application - Global Opportunity Analysis and Industry ... in 2015, and is expected to reach $5,255 million by 2022, growing at ... market in 2015 with more than four-fifths share. ... ...
(Date:12/5/2016)... Dec. 5, 2016  Wellbridge Health and Gateway Health proudly ... solutions to Medicare and Medicaid plan members with specific high ... the unique needs of this group of consumers, Wellbridge combines ... philosophies to provide insight into members, daily behaviors and lifestyle. ... , , ...
(Date:12/5/2016)... For the third consecutive year, Astellas has ... Rights Campaign Foundation,s (HRC) annual Corporate Equality ... tool used to rate companies on policies and practices ... For the last 15 years, HRC has ... equality efforts, culture and business practices. The survey rates ...
Breaking Medicine Technology: