Navigation Links
Study shows how normal cells influence tumor growth
Date:10/21/2009

COLUMBUS, Ohio It was once thought that the two communities of cells within a cancerous breast tumor fast-growing malignant cells and the normal cells that surround them existed independently, without interaction. Then evidence emerged indicating that the normal-looking cells encouraged cells within the tumor to become malignant, but how the one community influenced the other wasn't known.

A new study led by Ohio State University cancer researchers published in the Oct. 22 issue of Nature has begun solving the mystery. It shows for the first time that the loss of a gene called PTEN from one type of those surrounding cells can dramatically alter the tumor environment in ways that foster tumor growth.

"Our findings reveal a new role for this gene in the tumor environment, which could lead to entirely new treatments for breast cancer and perhaps other solid tumors using agents that target cells surrounding the tumor, as well as the cancer cells themselves," says co-principal investigator Gustavo Leone, associate professor of molecular virology, immunology and medical genetics at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

The findings should also improve the understanding of breast cancer and of other conditions that are influenced by the local tissue environment such as autoimmune disease, lung fibrosis and neurodegenerative diseases.

The PTEN gene produces a protein that is a key regulator of cell metabolism, and it is lost in many human cancers.

This new study shows that when PTEN is lost in fibroblasts, a principle cell component of the tissue that surrounds a tumor, it dramatically alters the structure and biochemical make-up of the tumor environment. For example, levels of the fibrous protein collagen rise, inflammatory cells called macrophages migrate into the tumor and the number of tumor blood vessels increases. These events all favor tumor growth.

"Our study demonstrates that PTEN in surrounding fibroblasts plays an important role in suppressing cancer development," says co-principal investigator Michael Ostrowski, professor and chair of molecular and cellular biochemistry and co-director of the cancer center's Molecular Biology and Cancer Genetics Program.

To show this, Leone, Ostrowski and their colleagues removed PTEN from fibroblasts in the mammary glands of mice. They were surprised to discover that PTEN regulates a second gene, called Ets2, which executes the changes that occur in the tumor environment when PTEN is lost.

"Remarkably, this animal model mimics many of the features observed in human breast cancer, " Leone says, "so it should help us evaluate experimental agents that might be used in combination therapies that target faulty cells in the tumor environment, as well as cancer cells."


'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Sex With a Partner Makes Evolutionary Sense: Study
2. Research partnership will study how electronic medical records can address genetics of drug safety
3. Internet fuels virtual subculture for sex trade, study finds
4. $8 million NIH grant for heart cell development and study
5. Study Forecasts More Young Doctors in Future
6. Frequency of Hospital Professional Liability Claims Increasing After Years of Declines, Says Aon and ASHRM Study
7. New Study Details Complex Health Care Needs of Medicaids Highest-Need, Highest-Cost Populations
8. Vascular Study Group of New England Selects Clinical Data Pathways, Powered by M2S, as Quality Improvement Registry Provider
9. Illness often undiscovered and undertreated among the uninsured: Harvard study
10. Thyroid surgery safe for older patients, study finds
11. New National Study of Crash-Involved Children Reaffirms Recommendations for Booster Seat Through Age 8
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... This campaign ... a stroke, which we as a society can control and change. , As nearly ... nearly every 40 seconds within the United States. Plus, with an estimated 129,000 of ...
(Date:5/27/2016)... ... , ... Beleza Medspa has initiated a new program to assist ... first time that Coolsculpting is being used for for more than just cosmetic purposes. ... meet the prescribed body-fat standard, measured by the circumference-based tape method. The tape-test ...
(Date:5/27/2016)... ... May 27, 2016 , ... Each ... studying complementary medicine. Allison Outerbridge is this year’s Life University winner ... 18 at the university’s Student Leadership Awards ceremony. , Outerbridge is approaching her ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... There are ... Hot Dog and Sausage Council (NHDSC) suggests that Americans prefer their dogs straight off ... 63 percent say grilling is their favorite way to cook a hot dog, far ...
(Date:5/26/2016)... Missouri (PRWEB) , ... May 26, 2016 , ... ... quality and clinical outcomes, hosted members and suppliers for its inaugural Member Conference ... focus on their mission of elevating the operational health of America’s healthcare providers. ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... biopharma company focused on the highly lucrative global ... substantial pipeline of potential first-in-class or best-in-class tyrosine ... in development with strategic partners. HCM,s profitable Chinese ... domestic market. We expect progress of the mid-to-late-stage ...
(Date:5/26/2016)... ALBANY, New York , May 26, 2016 ... Transparency Market Research "Medical Waste Management Market - U.S. Industry ... the medical waste management market in the U.S. was valued ... expand at a CAGR of 3.4% from 2015 to 2023 ... report provides exhaustive analysis of current and emerging needle free ...
(Date:5/26/2016)... , May 26, 2016 ... has matured into an essential life science tool for ... development applications. BCC Research reveals in its new report ... second growth phase, one powered by a range of ...      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ) , ...
Breaking Medicine Technology: