Navigation Links
Study shows how normal cells influence tumor growth
Date:10/21/2009

COLUMBUS, Ohio It was once thought that the two communities of cells within a cancerous breast tumor fast-growing malignant cells and the normal cells that surround them existed independently, without interaction. Then evidence emerged indicating that the normal-looking cells encouraged cells within the tumor to become malignant, but how the one community influenced the other wasn't known.

A new study led by Ohio State University cancer researchers published in the Oct. 22 issue of Nature has begun solving the mystery. It shows for the first time that the loss of a gene called PTEN from one type of those surrounding cells can dramatically alter the tumor environment in ways that foster tumor growth.

"Our findings reveal a new role for this gene in the tumor environment, which could lead to entirely new treatments for breast cancer and perhaps other solid tumors using agents that target cells surrounding the tumor, as well as the cancer cells themselves," says co-principal investigator Gustavo Leone, associate professor of molecular virology, immunology and medical genetics at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

The findings should also improve the understanding of breast cancer and of other conditions that are influenced by the local tissue environment such as autoimmune disease, lung fibrosis and neurodegenerative diseases.

The PTEN gene produces a protein that is a key regulator of cell metabolism, and it is lost in many human cancers.

This new study shows that when PTEN is lost in fibroblasts, a principle cell component of the tissue that surrounds a tumor, it dramatically alters the structure and biochemical make-up of the tumor environment. For example, levels of the fibrous protein collagen rise, inflammatory cells called macrophages migrate into the tumor and the number of tumor blood vessels increases. These events all favor tumor growth.

"Our study demonstrates that PTEN in surrounding fibroblasts plays an important role in suppressing cancer development," says co-principal investigator Michael Ostrowski, professor and chair of molecular and cellular biochemistry and co-director of the cancer center's Molecular Biology and Cancer Genetics Program.

To show this, Leone, Ostrowski and their colleagues removed PTEN from fibroblasts in the mammary glands of mice. They were surprised to discover that PTEN regulates a second gene, called Ets2, which executes the changes that occur in the tumor environment when PTEN is lost.

"Remarkably, this animal model mimics many of the features observed in human breast cancer, " Leone says, "so it should help us evaluate experimental agents that might be used in combination therapies that target faulty cells in the tumor environment, as well as cancer cells."


'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Sex With a Partner Makes Evolutionary Sense: Study
2. Research partnership will study how electronic medical records can address genetics of drug safety
3. Internet fuels virtual subculture for sex trade, study finds
4. $8 million NIH grant for heart cell development and study
5. Study Forecasts More Young Doctors in Future
6. Frequency of Hospital Professional Liability Claims Increasing After Years of Declines, Says Aon and ASHRM Study
7. New Study Details Complex Health Care Needs of Medicaids Highest-Need, Highest-Cost Populations
8. Vascular Study Group of New England Selects Clinical Data Pathways, Powered by M2S, as Quality Improvement Registry Provider
9. Illness often undiscovered and undertreated among the uninsured: Harvard study
10. Thyroid surgery safe for older patients, study finds
11. New National Study of Crash-Involved Children Reaffirms Recommendations for Booster Seat Through Age 8
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
Breaking Medicine Technology: