Navigation Links
Study shows how inflammation can lead to cancer
Date:4/19/2011

COLUMBUS, Ohio A new study shows how inflammation can help cause cancer. Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25 percent of all cancers.

This study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) found that inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155).

This, in turn, causes a drop in levels of proteins involved in DNA repair, resulting in a higher rate of spontaneous gene mutations, which can lead to cancer.

"Our study shows that miR-155 is upregulated by inflammatory stimuli and that overexpression of miR-155 increases the spontaneous mutation rate, which can contribute to tumorigenesis," says first author and post-doctoral researcher Dr. Esmerina Tili. "People have suspected for some time that inflammation plays an important role in cancer, and our study presents a molecular mechanism that explains how it happens."

"Our findings also suggest that drugs designed to reduce miR-155 levels might improve the treatment of inflammation-related cancers," Tili says.

The findings were published recently in the Proceedings of the National Academy of Sciences.

MicroRNAs form a large family of non-coding genes involved in many important cell processes. They carry out this function by suppressing the amount of particular proteins in cells, with each type of microRNA often affecting many different proteins.

MiR-155 is known to influence blood-cell maturation, immune responses and autoimmune disorders, and high levels of this molecule have been directly linked to the development of leukemias, and breast, lung and gastric cancers.

For this study, Tili and her colleagues examined the effects of inflammation-promoting substances such as tumor necrosis factor or lipopolysaccharide (found in the outer walls of bacteria) on miR-155 expression and on the frequency of spontaneous mutations in several breast-cancer cell lines.

When the researchers exposed breast-cancer cells to the two inflammatory factors the levels of miR-155 rose abnormally high, and the mutation rate increased two- to three-fold. To understand why, the investigators focused on the WEE1 gene, which stops the process of cell division to allow damaged DNA to be repaired.

The investigators learned that miR-155 also targets WEE1 and showed that high levels of miR-155 lead to low levels of WEE1. They reasoned that low levels of WEE1 allowed cell division to continue even when DNA damage is present, leading to a growing number of mutations.

"It is believed that cancer is caused by an accumulation of mutations in cells of the body," says principal investigator Dr. Carlo M. Croce, professor and chair of molecular virology, immunology and medical genetics, and director of the Human Cancer Genetics program the OSUCCC James. "Our study suggests that miR-155, which is associated with inflammation, increases the mutation rate and might be a key player in inflammation-induced cancers generally. This could make it an important therapeutic target."


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Poor Sense of Smell Not a Big Loss for Most People: Study
2. Parents Want Genetic Testing for Kids: Study
3. Results on national study of parental concerns about childhood vaccines announced
4. Overdose deaths down 35 percent after opening of Vancouvers supervised injection site: UBC-BC-CfE study
5. High-deductible health plans pose no special risks to the medically vulnerable, study finds
6. Study: Parents likely to embrace predictive genetic testing for their children if offered
7. Study links social environment to high attempted suicide rates among gay youth
8. Alcohol-Energy Drink Combo Riskier Than Booze Alone, Study Says
9. Large study finds ICS therapy reduces pneumonia mortality
10. Early School Start Tied to More Teen Crashes: Study
11. Study examines new treatment for recurrent urinary tract infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... , ... Shark Finds and Kevin Harrington, along with the Product ... with Belly Bands. , Having a dog is great—except when it wets every couch, ... nothing works, get Belly Bands, the easiest way to stop dogs from wetting ...
(Date:2/5/2016)... ... February 05, 2016 , ... VeloReality ... lighter, sleeker next generation LYNX VR Indoor Trainer with multi-rider capability to an ... and manufacturing not only reduce the weight of the unit, they also enhance ...
(Date:2/5/2016)... ... 2016 , ... The Muscular Dystrophy Association and Sailormen Inc., ... 14th annual “Appetite for a Cure” campaign on Feb. 1 to raise critical ... diseases that severely limit strength and mobility. , Now through March 20, ...
(Date:2/5/2016)... ... February 05, 2016 , ... After years as an ... Burn Unit, plastic and cosmetic surgeon Dr. Wayne Carman transitioned to chief of the ... successfully completed his first three-year term as chief and began a second three-year term ...
(Date:2/5/2016)... ... February 05, 2016 , ... The American public tends ... water may be safer than regular municipal or well water. The recent experience with ... Sharon Kleyne, could go a long way toward increasing public acceptance of recycled waste ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Wegener Polyangiitis - Pipeline Review, H2 ... Polyangiitis - Pipeline Review, H2 2015, provides an ... This report provides comprehensive information on the therapeutic ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ...
(Date:2/4/2016)... -- Summary Breast cancer, a malignant neoplasm, is ... cancer in women worldwide, accounting for 16% of all ... of women diagnosed with breast cancer has increased over ... has declined due to earlier diagnosis and better treatment ... the past four decades, especially with increasing usage of ...
(Date:2/4/2016)... Feb. 4, 2016 Frontier Pharma: Chronic ... First-in-Class Innovation Chronic Obstructive Pulmonary ... chronic inflammation of the airways and lungs. Persistent ... make the disease one of the leading causes ... in the world. COPD is linked to cumulative ...
Breaking Medicine Technology: