Navigation Links
Study shows how inflammation can lead to cancer
Date:4/19/2011

COLUMBUS, Ohio A new study shows how inflammation can help cause cancer. Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25 percent of all cancers.

This study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) found that inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155).

This, in turn, causes a drop in levels of proteins involved in DNA repair, resulting in a higher rate of spontaneous gene mutations, which can lead to cancer.

"Our study shows that miR-155 is upregulated by inflammatory stimuli and that overexpression of miR-155 increases the spontaneous mutation rate, which can contribute to tumorigenesis," says first author and post-doctoral researcher Dr. Esmerina Tili. "People have suspected for some time that inflammation plays an important role in cancer, and our study presents a molecular mechanism that explains how it happens."

"Our findings also suggest that drugs designed to reduce miR-155 levels might improve the treatment of inflammation-related cancers," Tili says.

The findings were published recently in the Proceedings of the National Academy of Sciences.

MicroRNAs form a large family of non-coding genes involved in many important cell processes. They carry out this function by suppressing the amount of particular proteins in cells, with each type of microRNA often affecting many different proteins.

MiR-155 is known to influence blood-cell maturation, immune responses and autoimmune disorders, and high levels of this molecule have been directly linked to the development of leukemias, and breast, lung and gastric cancers.

For this study, Tili and her colleagues examined the effects of inflammation-promoting substances such as tumor necrosis factor or lipopolysaccharide (found in the outer walls of bacteria) on miR-155 expression and on the frequency of spontaneous mutations in several breast-cancer cell lines.

When the researchers exposed breast-cancer cells to the two inflammatory factors the levels of miR-155 rose abnormally high, and the mutation rate increased two- to three-fold. To understand why, the investigators focused on the WEE1 gene, which stops the process of cell division to allow damaged DNA to be repaired.

The investigators learned that miR-155 also targets WEE1 and showed that high levels of miR-155 lead to low levels of WEE1. They reasoned that low levels of WEE1 allowed cell division to continue even when DNA damage is present, leading to a growing number of mutations.

"It is believed that cancer is caused by an accumulation of mutations in cells of the body," says principal investigator Dr. Carlo M. Croce, professor and chair of molecular virology, immunology and medical genetics, and director of the Human Cancer Genetics program the OSUCCC James. "Our study suggests that miR-155, which is associated with inflammation, increases the mutation rate and might be a key player in inflammation-induced cancers generally. This could make it an important therapeutic target."


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Poor Sense of Smell Not a Big Loss for Most People: Study
2. Parents Want Genetic Testing for Kids: Study
3. Results on national study of parental concerns about childhood vaccines announced
4. Overdose deaths down 35 percent after opening of Vancouvers supervised injection site: UBC-BC-CfE study
5. High-deductible health plans pose no special risks to the medically vulnerable, study finds
6. Study: Parents likely to embrace predictive genetic testing for their children if offered
7. Study links social environment to high attempted suicide rates among gay youth
8. Alcohol-Energy Drink Combo Riskier Than Booze Alone, Study Says
9. Large study finds ICS therapy reduces pneumonia mortality
10. Early School Start Tied to More Teen Crashes: Study
11. Study examines new treatment for recurrent urinary tract infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... Hill, NC (PRWEB) , ... February 23, 2017 , ... ... Platinum Sponsor for ACPA’s 74th Annual Meeting. KLS is a longtime supporter of ... 2017 as an exhibitor and Platinum Sponsor," said Dr. Bob Havlik, 2017 ACPA President. ...
(Date:2/23/2017)... Lawn, NJ (PRWEB) , ... February 23, 2017 ... ... specializing in thought leadership , media relations, content marketing, social media management, ... With several clients already in the state and in nearby New Hampshire, Massachusetts ...
(Date:2/23/2017)... ... February 23, 2017 , ... Dr. David Mahon leads Siena Dental, a ... Mahon was named a 2017 Top Patient Rated Henderson Dentist by Find ... that recognizes local physicians and dentists who have earned high ratings and superior patient ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... Phoenix, announced today that it will soon begin franchising throughout the U.S. starting ... mission to help bring the practice of meditation mainstream. Current Meditation will be ...
(Date:2/23/2017)... ... (PRWEB) February 23, 2017 -- ... to come together to combine its favorite springtime pastime – ... fruit – apples! To celebrate National Nutrition Month, the U.S. ... Madness” bracket tournament – a five-week, five-round online competition spotlighting ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... 23, 2017 The top three ... GE Healthcare, Koninklijke Philips N.V., and Schiller. Collectively, these ... global market in 2015. Strong product portfolio and a ... to be aiding these players remain leaders in the ... players in the global market are likely to focus ...
(Date:2/23/2017)... February 23, 2017 On Wednesday, February ... as four out of nine sectors finished the trading sessions ... a flat closing. Major US indices were also mixed at ... day at 5,860.63, slightly down by 0.09%; the Dow Jones ... the S&P 500 closed at 2,362.82, down 0.11%. This Thursday ...
(Date:2/23/2017)... , Feb. 23, 2017   SeraCare Life ... global in vitro diagnostics manufacturers and clinical laboratories, ... "Catalyzing Implementation of NGS-Based Tests" to be hosted ... 2017 at 11am Eastern Standard Time (US). ... highlight the need for improved performance and global ...
Breaking Medicine Technology: