Navigation Links
Study shows gene variations may predict risk of breast cancer in women
Date:5/2/2008

CHICAGO According to a recent study, led by Virginia Kaklamani, MD, an oncologist at Northwestern Memorial Hospital and assistant professor of medicine, Northwestern University Feinberg School of Medicine, variations of the adiponectin gene, which regulates a number of metabolic processes, may increase a womans risk of developing breast cancer. This discovery is an important step forward in cancer genetics research, as it could help experts develop a future genetic testing model to more accurately predict a womans risk of developing breast cancer.

Dr. Kaklamanis research, which is published in the May 1 issue of Cancer Research, suggests some women are born with different characteristics in the adiponectin gene which can alter its function and increase the risk of breast cancer. This finding, coupled with previous studies that have found a correlation between low levels of adiponectin in the body and cancer risk, suggest adiponectin may be the third gene linked to breast cancer among women with no previous family history of breast cancer. If confirmed through additional studies, adiponectin could be used along with TGF-beta and CHEK2, genes that have already been linked to breast cancer, to create a genetic testing model that will allow clinicians to more accurately predict breast cancer risk.

Clinicians currently rely on epidemiologic models to predict breast cancer risk. The most common is the GAIL model, which looks at a number of factors including a womans current age, the age she began menstruating, her age at menopause, age of first live birth, previous biopsies and family history.

All we know is that one in eight women will get breast cancer somehow, for some reason, says Dr. Kaklamani. One explanation for this is genetic background, and the adiponectin gene is one that may be responsible. By pinpointing which genes are associated with breast cancer risk, we can better predict risk, and ultimately may be able to enhanc
'/>"/>

Contact: Kimberly Arndt
karndt@nmh.org
312-926-6503
Northwestern Memorial Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... 13, 2014 Victorian Hotel has recently ... the rental of bikes for its "Cycle the City" ... Hotel to tour the area using a rental bicycle, ... enthusiasts love to call Vancouver home, as it is ... travel and picturesque journeys through the countryside. Vancouver hotel ...
(Date:7/13/2014)... July 13, 2014 Micro irrigation systems ... proper water dispersal as wells as to maintain soil ... is projected to become a dominant revenue generator for ... methods to reduce resource costs has led to the ... plantations, and has further caused massive demand for micro ...
(Date:7/13/2014)... July 13, 2014 Advanced boilers ... the least amount of fossil fuels, produce high-capacity ... Due to increased global warming and climate change ... to reduce harmful gas emissions and pollutants coming ... market in the global advance boilers market., The ...
(Date:7/13/2014)... According to a new market research ... Component (processor, GPU, DSP, connectivity), Technology Node (45nm-5nm), ... - Forecast and Analysis to 2014-2020", published by ... Market is expected to reach $61.70 Billion by ... 2014 to 2020. , Browse 71 market data ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 A Massachusetts ... to the cancer risks associated with power morcellators ( ... their story to federal regulators, as they presented poignant ... Food & Drug Administration (FDA) advisory panel meeting convened ... According to the Rochester Democrat and Chronicle, Dr. Hooman ...
Breaking Medicine News(10 mins):Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Heterogeneous Mobile Processing & Computing Market Worth $61.70 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4
... The contaminant bisphenol-A (BPA)—widely used to make many plastics ... long-term effects in female// development, according to a recent ... ,Lead investigator Hugh S. Taylor, M.D., associate professor ... (Ob/Gyn) at Yale, said the study shows that BPA ...
... (Viramune) is associated with a higher risk of rash, ... of the drug, according to Canadian research published in ... found that individuals who took nevirapine once daily were ... took the drug twice a day. For these reasons, ...
... consumers not to purchase, or use, Wild Kitty Cat Food ... monitoring activities, FDA collected and analyzed a sample of frozen ... product. Cats and other pets consuming this food may become ... if they handle or ingest this cat food, touch pets ...
... government warned on Tuesday of potentially life-threatening twisting of ... is the leading cause of early childhood diarrhea. ... led to the withdrawal of the first rotavirus vaccine ... Administration said it was unknown whether the recently approved ...
... has swung in favor of the coffee//. ,There ... on the relation of coffee with heart diseases. ... and led by Dr. Sarah A. Rosner conducted a research on ... ,This was conducted from 1987 to 1990. Results were ...
... is said to be associated with insecure feeling. This was ... led by Angelo Picardi of Italian National Institute of Health ... was conducted on 61 healthy women who were younger than ... women who were unable to form lasting and permanent relationships ...
Cached Medicine News:Health News:Once-daily Nevirapine Has More Side-effects Than Twice-daily Dose 2Health News:Once-daily Nevirapine Has More Side-effects Than Twice-daily Dose 3Health News:Consumers Warned of Using Cat Food Due to Salmonella Contamination 2Health News:FDA: Rotavirus Vaccine May Harm Infants 2
(Date:7/10/2014)... , July 10, 2014 Yesterday, ... Research,s (Moberg) medical device manufacturing facility. Rep. Kennedy ... advanced neurological monitors facilitate cutting-edge research in neurological ... Kennedy and mental health advocate, Garen Staglin ... dedicated to fostering fundamental changes that will radically ...
(Date:7/10/2014)... 2014   Ventana Medical Systems, Inc.  (Ventana), a ... entered into an agreement with Merck KGaA, Darmstadt, ... in the United States and ... KGaA,s biopharmaceutical division on the development and commercialization of ... Ventana,s proprietary diagnostic assays. In alignment with Merck KGaA,s ...
(Date:7/10/2014)... R.I. , July 10, 2014 CVS Caremark ... board of directors has approved a quarterly dividend of $0.275 ... dividend is payable on August 1, 2014, to holders of ... CVS Caremark is dedicated to helping people ... pharmacy company in the United States . ...
Breaking Medicine Technology:Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... Sept. 21 As consumer healthcare expenses rise, ... customer satisfaction has increased considerably from 2009, according ... National Pharmacy Study(SM) released today. ... http://www.newscom.com/cgi-bin/prnh/20050527/LAF028LOGO-a ) The study, now in ...
... 21 HealthWarehouse.com, Inc. (OTC Bulletin Board: ... Columbia Medical Associates, an outpatient clinic system offering medical ... partnership to offer patients a 30-day supply of more ... home delivery. Columbia Medical Associate,s "Columbia Care" ...
Cached Medicine Technology:J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 2J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 3J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 4J.D. Power and Associates Reports: As Consumers Shoulder More Healthcare Expenses, Cost Increasingly Drives Overall Customer Satisfaction With Pharmacies 5HealthWarehouse.com Partners with Columbia Medical Associates to Bring Affordable Healthcare to Washington State 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: