Navigation Links
Study shows gene positions may aid cancer diagnosis
Date:12/7/2009

Certain genes switch their nuclear position in tumor cells, offering a potential new method of diagnosing cancer, say researchers from the National Cancer Institute. The study by Meaburn et al. will be published online December 7, 2009 (www.jcb.org) and in the December 14, 2009 print issue of the Journal of Cell Biology (JCB).

Individual genes preferentially localize to specific points within the nucleus. The reasons for this aren't known, but the positions can be reshuffled during differentiation. Meaburn et al. wondered whether genes might also rearrange during carcinogenesis, when large-scale changes in nuclear morphology occur. The researchers previously identified four genes that shift their location in a 3D culture model of early breast cancer, and now turned their attention to human tissue.

The team analyzed 20 genes and found that most were positioned uniformly in healthy breast tissue from numerous individuals. Eight of these genes consistently relocated in the nuclei of invasive breast cancer cells, including HES5, which had an altered localization in all tumors examined. The researchers were able to distinguish between normal and diseased tissue on the sole basis of these genes' nuclear localization with success rates similar to current clinical tests.

The next step, says lead author Karen Meaburn, will be to repeat the study on a larger number of samples. HES5 is unlikely to be repositioned in all of these, so the authors hope to identify a set of genes that, in combination, can accurately diagnose breast cancer. The approach may be useful for prognosis, tooin vitro studies suggest that gene movements are an early event in cancer development, so gene positions might provide an indication of the cancer's future progress.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related medicine news :

1. Data from Phase 1 Study Confirm High Response Rate of Micromets Blinatumomab in Patients with Non-Hodgkins Lymphoma
2. Military children face more emotional challenges as parental deployments grow longer, study finds
3. New study finds barriers to pain treatment in children with sickle cell disease
4. BetterInvesting Magazine Releases February Stock to Study and Undervalued Stock Choicesfor Investors Informational and Educational Use
5. News brief -- childhood cancer survivor study report: Late recurrence is a risk for some cancers
6. Muscle cell infusion shown to strengthen sphincters in animals in Stanford study
7. Congress Has Allowed Most Previous Medicare Cuts to Take Effect, New Study Shows
8. NYU Langone Medical Center Study Shows VNS Therapy is a Safe and Effective Treatment for Refractory Epilepsy
9. Diabetes Drugs Go Head-to-Head in Study
10. Cell Phone Text Messaging Technology is a Low-Cost, Effective Way to Improve Use of Sunscreen and Reduce Risk of Skin Cancer, According to a New Study
11. Personality predicts success in medical school, says new study by U of Minnesota professor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study shows gene positions may aid cancer diagnosis
(Date:7/12/2014)... United Arab Emirates (PRWEB) July 12, 2014 ... another Los Angeles basketball legend is heading to the ... scorer and six-time champion will be in the UAE ... & Fitness Weekend in support of diabetes awareness. The ... an award-winning entertainment marketing and event management company based ...
(Date:7/12/2014)... Amarillo, Texas (PRWEB) July 12, 2014 ... and Breastfeeding Made Simple as a valuable new resource ... that roughly two-thirds of American women work away from ... many sources touting the benefits of breastfeeding, but often ... continuing to nurse their babies. With its evidence-based insights, ...
(Date:7/12/2014)... Restore My Vision Today is a new ... couple boasting very impressive credentials on the field of ... as a way to help consumers do without the ... respective patients’ treatments . , In particular, ... of pertinent information relevant to eye care like:, ...
(Date:7/12/2014)... 2014 Maxim Peptide, a website that ... used solely in scientific experiments, is currently celebrating its ... business, Maxim Peptide, which was created by the founders ... and updated website that now features a special deals ... updated with fascinating articles about peptide research, including a ...
(Date:7/12/2014)... 12, 2014 Ladies, it doesn't matter what ... Those who are looking for an affordable gown can ... occasion dresses) to get their dream items. Recently, the company ... length gowns . Along with that, it is also providing ... the special offer; the deadline of this promotion is July ...
Breaking Medicine News(10 mins):Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:Worldwide Brides-to-be: It Is Time To Show Your Beauty By Wearing A Trendy Summer Short Wedding Dress From Discount-Dress.com 2
... of Northwestern University, is a super sleuth of potentially ... team of doctors called RADAR (Research on Adverse ... School of Medicine. They swoop in to investigate early ... Administration (FDA) takes notice. ,A new study ...
... Court on Friday announced that it has accepted a ... to review the constitutionality of a Mexico City law ... the first three months' gestation, the Los Angeles Times ... Democratic Revolution in March in the Mexico City Legislature ...
... such as Girls Aloud, Pussycat Dolls and the Sugababes have ... promoting an ideal for what a womans figure should look ... ,Researchers from the universities of Leeds and Sussex ... where all the band-members are skinny, found that watching such ...
... in Physiological and Biochemical Zoology, a fascinating new ... evolution and artificial selection, providing insight into ... fluctuations. ,Dr. James Hicks, Editor in ... collection of papers: "This exciting approach experimental ...
... good for the fairer sex, for a new study has found that ... as fast as if she has just had a grueling workout. ... a group of 35 women and found that trying on a pair ... beats per minute. ,And, this is not just a one ...
... up boozing from home. ,Based on this, ... away from their middle school children, the best place to ... by a team of researchers including principal investigator Kelli Komro ... Minnesota, Minneapolis. ,As part of the study, researchers ...
Cached Medicine News:Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 2Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 3Health News:Mexico Supreme Court Accepts Petition To Review Mexico City Law Legalizing Abortion During First Three Months' Gestation 2Health News:Research Throws Light on Adaptation of E.coli to Changing Conditions 2
(Date:7/11/2014)... July 11, 2014 Research and Markets ... and Chinese Medical X-ray Film Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 Global And Chinese Medical X-Ray ... study on the current state of the Global medical ... situation. The report provides a basic overview of ...
(Date:7/11/2014)... On Thursday, July 10, 2014, the NASDAQ ... Average finished the day 0.42% lower at 16,915.07, and the ... broad based as eight out of ten sectors ended the ... ended the day at 711.88, down 0.02%, while the index ... initiated coverage on the following equities: Covidien PLC (NYSE: ...
(Date:7/11/2014)... Neurelis, Inc. ("Neurelis") today announced an agreement ... held by Biotie to purchase Neurelis, clearing the way ... diazepam) for pediatric and adult epilepsy patients who experience ... Biotie has advanced the development program for NRL-1 and ... work required for NDA submission to the FDA.  Given ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
... includes three major components: Blood pump, Cannulae, ... Driver. This system provides partial or total ... conventional therapy, is unable to maintain adequate ... support, blood flows from the natural heart ...
Datascope presents a unique new product for post-hemostasis puncture site management. Safeguard is the first product ever to combine a built-in inflatable bulb and a sterile dressing- providing adjus...
... catheter is inserted into the subclavian or ... vena cava. The Cool Line incorporates ... temperature-controlled saline flowing within a closed-loop design, ... circulation. The Cool Line combines two ...
... The Fortius catheter provides maximum ... to target temperature. The Fortius catheter ... design to provide the ultimate solution ... catheter is inserted percutaneously into the ...
Medicine Products: