Navigation Links
Study shows gene positions may aid cancer diagnosis
Date:12/7/2009

Certain genes switch their nuclear position in tumor cells, offering a potential new method of diagnosing cancer, say researchers from the National Cancer Institute. The study by Meaburn et al. will be published online December 7, 2009 (www.jcb.org) and in the December 14, 2009 print issue of the Journal of Cell Biology (JCB).

Individual genes preferentially localize to specific points within the nucleus. The reasons for this aren't known, but the positions can be reshuffled during differentiation. Meaburn et al. wondered whether genes might also rearrange during carcinogenesis, when large-scale changes in nuclear morphology occur. The researchers previously identified four genes that shift their location in a 3D culture model of early breast cancer, and now turned their attention to human tissue.

The team analyzed 20 genes and found that most were positioned uniformly in healthy breast tissue from numerous individuals. Eight of these genes consistently relocated in the nuclei of invasive breast cancer cells, including HES5, which had an altered localization in all tumors examined. The researchers were able to distinguish between normal and diseased tissue on the sole basis of these genes' nuclear localization with success rates similar to current clinical tests.

The next step, says lead author Karen Meaburn, will be to repeat the study on a larger number of samples. HES5 is unlikely to be repositioned in all of these, so the authors hope to identify a set of genes that, in combination, can accurately diagnose breast cancer. The approach may be useful for prognosis, tooin vitro studies suggest that gene movements are an early event in cancer development, so gene positions might provide an indication of the cancer's future progress.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related medicine news :

1. Data from Phase 1 Study Confirm High Response Rate of Micromets Blinatumomab in Patients with Non-Hodgkins Lymphoma
2. Military children face more emotional challenges as parental deployments grow longer, study finds
3. New study finds barriers to pain treatment in children with sickle cell disease
4. BetterInvesting Magazine Releases February Stock to Study and Undervalued Stock Choicesfor Investors Informational and Educational Use
5. News brief -- childhood cancer survivor study report: Late recurrence is a risk for some cancers
6. Muscle cell infusion shown to strengthen sphincters in animals in Stanford study
7. Congress Has Allowed Most Previous Medicare Cuts to Take Effect, New Study Shows
8. NYU Langone Medical Center Study Shows VNS Therapy is a Safe and Effective Treatment for Refractory Epilepsy
9. Diabetes Drugs Go Head-to-Head in Study
10. Cell Phone Text Messaging Technology is a Low-Cost, Effective Way to Improve Use of Sunscreen and Reduce Risk of Skin Cancer, According to a New Study
11. Personality predicts success in medical school, says new study by U of Minnesota professor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study shows gene positions may aid cancer diagnosis
(Date:4/18/2015)... Raleigh, NC (PRWEB) April 18, 2015 ... the risk of developing mesothelioma later in life, but ... ways from mesothelioma that is unrelated to radiation. Surviving ... study on its website. Click here to read ... and Australia compared the cases of 45 patients who ...
(Date:4/18/2015)... April 18, 2015 Aureus Medical ... staffing, including physical therapy jobs, has announced that ... South Carolina Physical Therapy Association Annual Conference to ... Center in Greenville, SC. , The SCAPTA ... exhibits with products and services. , Representatives ...
(Date:4/17/2015)... Bradley, Illinois (PRWEB) April 17, 2015 ... host a Party on the Patio from 2 p.m. ... which is located at 1320 Executive Ct. in Pekin, ... on Medicaid, who need some help to maintain their ... steel drums, and tropical treats will be served during ...
(Date:4/17/2015)... Florida Hospital Wesley Chapel, Florida Hospital at ... were all selected as Top Workplaces in Tampa Bay. ... is ranked number one for large businesses according to ... in partnership with an independent research firm. Florida Hospital ... opened in October of 2012 with a vision of ...
(Date:4/17/2015)... April 17, 2015 Representatives Jim Himes ... and Treatment Act HR 1849 in congress on April ... and treatment for patients with the genetic disease. ... past, would be the first to create a federally ... treatment of hereditary hemorrhagic telangiectasia. This would effectively prevent ...
Breaking Medicine News(10 mins):Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2Health News:John Evans Supportive Living Community Prepares for Party on the Patio 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 3Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 4Health News:House Representatives Introduce Bill to Fight Genetic Disease 2
... 2010) High doses of antioxidant nutritional supplements, such ... cells, which may predispose supplement-takers to developing cancer, according to ... The study, led by Eduardo Marbn, M.D., Ph.D., director ... the medical journal Stem Cells . The study ...
... find early stage cancers and precancerous growths than current ... -- Noninvasive stool DNA testing can detect two types ... in colon cancer prevention, say two new studies. , ... testing has higher detection rates for curable stage colorectal ...
... readmissions, study finds , TUESDAY, May 4 (HealthDay News) -- ... heart failure patient discharged from the hospital reduces the chance ... but that preventive measure is more often ignored than observed, ... 30,000 hospital patients covered by Medicare found that fewer than ...
... CINCINNATIThe popular diabetes medication metformin works in different fashion ... could lead to wider use of the drugparticularly in ... like tuberous sclerosis and lymphangioleiomyomatosis (LAM). The ... scientific director of UC,s Metabolic Diseases Institute, are published ...
... many times have you, after a particularly hard day, reached ... people, but for those trying to lose weight, it can ... programs never even address it. They focus on choosing ... key question: how can people who have eaten to cope ...
... ... cleaning machine that combines high impact cleaning efficiency with extended operating life, reduced life cycle ... can be completely stripped and rebuilt for maintenance ON-SITE in less than 15 minutes. ... (PRWEB) May 4, 2010 -- ...
Cached Medicine News:Health News:High doses of antioxidant supplements induce stem cell genetic abnormalities 2Health News:New Test for Colon Cancer Under Development 2Health News:Hospitals Falling Short on Heart Patients' Follow-Up Care 2Health News:Popular diabetes drug works differently than thought 2Health News:Managing the emotions behind eating 2Health News:BETE Fog Nozzle Announces HydroWhirl™ Orbitor – Clean-In-Place Rotating Tank Cleaning Machine with High Impact Cleaning for Extended Operating Life 2
(Date:4/17/2015)... April 17, 2015  Over the next five years, the ... grow, with ArcView predicting that 14 more states will legalize ... The U.S. market for legal cannabis grew 74 percent in ... Analysts project the market could grow more than fourfold to ... soften their stance on marijuana. Cannabiz Mobile Inc. ...
(Date:4/17/2015)... April 17, 2015 Today, the Pharmaceutical ... employees from 12 biopharmaceutical companies as "We Work ... policy advocacy and community service. Established ... Awards were created by the biopharmaceutical industry to ... their careers, but have also shown an outstanding ...
(Date:4/17/2015)... , April 17, 2015   IBA ... of radiopharmaceuticals, announced today that it has signed a ... North America, Inc. (IBAM NA), to Illinois Health and Science ... operate as an independent company headquartered in ... to take advantage of new product and footprint synergies. ...
Breaking Medicine Technology:Cannabiz Mobile Analyst Brief: Next Big Thing by Torus IR Issued by BrokerBank Securities, Inc. 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 3Health Care System to Acquire IBA Molecular North America 2Health Care System to Acquire IBA Molecular North America 3
... Md., Sept. 11 Northwest,Biotherapeutics, Inc. (OTC Bulletin ... "Company") today announced the most recent long-term,follow-up data, ... I and Phase,I/II clinical trials with DCVax(R)-Brain, which ... multiforme, the most lethal type of brain,cancer. This ...
... AUSTIN, Texas, Sept. 10 The first-ever human,clinical ... tea was,recently conducted, testing whether the tea can ... new trial also generated the first human safety ... that,short-term consumption of rooibos tea is safe for ...
Cached Medicine Technology:Long-Term Phase I and Phase I/II Trial Data Continue to Show Striking Improvement in Survival of Brain Cancer Patients Who Receive DCVax(R)-Brain 2Long-Term Phase I and Phase I/II Trial Data Continue to Show Striking Improvement in Survival of Brain Cancer Patients Who Receive DCVax(R)-Brain 3Long-Term Phase I and Phase I/II Trial Data Continue to Show Striking Improvement in Survival of Brain Cancer Patients Who Receive DCVax(R)-Brain 4Long-Term Phase I and Phase I/II Trial Data Continue to Show Striking Improvement in Survival of Brain Cancer Patients Who Receive DCVax(R)-Brain 5Long-Term Phase I and Phase I/II Trial Data Continue to Show Striking Improvement in Survival of Brain Cancer Patients Who Receive DCVax(R)-Brain 6Clinical Trial Shows Cardiovascular Benefits of Rooibos, Popular Antioxidant Herbal Tea from South Africa 2Clinical Trial Shows Cardiovascular Benefits of Rooibos, Popular Antioxidant Herbal Tea from South Africa 3Clinical Trial Shows Cardiovascular Benefits of Rooibos, Popular Antioxidant Herbal Tea from South Africa 4Clinical Trial Shows Cardiovascular Benefits of Rooibos, Popular Antioxidant Herbal Tea from South Africa 5
Illuminated Phoroptor Refracting Instrument. Illumination is provided by a cool-running, energy efficient LEDs (Light Emitting Diodes) that light only what you need to see without affecting the darke...
Double Maddox...
Maddox Rod, short handle (12cm)...
... The Snellen chart remains to most ... range of different optotypes can be ... sheridan-gardner, landolt Cs, tumbling Es and ... column can be shown and a ...
Medicine Products: