Navigation Links
Study shows epigenetic changes in children with Crohn's disease
Date:8/22/2014

August 22, 2014 A new study finds a wide range of epigenetic changesalterations in DNA across the genome that may be related to key environmental exposuresin children with Crohn's disease (CD), reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

The study provides "compelling evidence" of alterations of DNA in several regions of the genome in children with CD, according to Professor Jack Satsangi of University of Edinburgh and colleagues. In addition to providing new insights into how genes and the environment interact, the results may have early implications for clinical management of CD.

Epigenetic Changes in Childhood-Onset Crohn's Disease

The researchers performed a "genome-wide" study in children with newly diagnosed CD, before any treatment, to look for possible epigenetic changes that may affect gene behavior. Epigenetic changes reflect the impact of a wide range of environmental factors on genes.

The results showed strong evidence of such changes at 65 different sites across the genome. Nineteen sites showed clustering of epigenetic changes, pointing at genetic pathways that might be relevant to CD development.

Similar patterns were present in a separate group of children who had been treated for CD, as well as in a group of treated adults.

The study highlighted "highly significant" changes in two specific gene locations (loci), which include genes responsible for immune and cellular functions that could contribute to the development of CD. Two probes for these loci were highly accurate in predicting which children would have CD, providing a potentially useful "b
'/>"/>

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study identifies challenges faced by NYU nurses after Hurricane Sandy
2. Racial Disparities in Breast-Feeding May Start With Hospitals, Study Suggests
3. New Pediatrics Study Reveals Dramatic Increase in Speech Problems in Children Over Past Decade
4. Dr. Mary Hayes: Study Shows 3D Mammography Finds More Invasive Cancers While Reducing Unnecessary Recalls
5. Fewer U.S. Teens Using Sunscreen, Study Finds
6. Difficulty assessing effort drives motivation deficits in schizophrenia, study finds
7. Study: Men, Lesbians More Likely to Have Orgasms
8. Kids With Autism Have Extra Brain Connections, Study Says
9. Study shows steep decline in tooth loss, increase in socioeconomic disparities
10. Study Finds Bacteria Compound Shrinks Mesothelioma Tumors, According to Surviving Mesothelioma
11. Study Suggests Environmental Factors May Outweigh Genetics When It Comes to Myopia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Slone Partners , a national ... information technology, and laboratory testing industries, has promoted ... Officer. The announcement comes after a year of ... presence in Boston and several new additions to ... the client experience," said Adam Slone, Chief Executive ...
(Date:12/19/2014)... Dallas, TX (PRWEB) December 19, 2014 ... current state of the global Gliquidone industry with a ... statistics on the market status of the Gliquidone manufacturers ... for companies and individuals interested in the industry. , ... industry including its definition, applications and manufacturing technology. Then, ...
(Date:12/19/2014)... 19, 2014 The Hermitage Club ... in Southern Vermont’s Deerfield Valley, announced today that it ... classic rock songs. , Three time Grammy Award ... private concert followed by a trail naming ceremony. Hermitage ... names include: “I’m Alright” the theme song for the ...
(Date:12/19/2014)... 18, 2014 (HealthDay News) -- A new study suggests ... to severe hot flashes and night sweats -- and ... Hot flashes are common during menopause, affecting about 60 ... affect women after menopause, since they then face a ... findings suggest women who exhibit moderate or severe menopausal ...
(Date:12/19/2014)... HealthDay Reporter THURSDAY, Dec. 18, 2014 ... to high levels of air pollution late in pregnancy may ... suggests. Researchers found that of nearly 1,800 U.S. women ... the most air pollution during pregnancy were twice as likely ... during the third trimester, specifically, showed the strongest correlation to ...
Breaking Medicine News(10 mins):Health News:Slone Partners Promotes Leslie Loveless to Chief Operating Officer 2Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 2Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 3Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 4Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 5Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 6Health News:The Hermitage Club Officially Names Four Ski Trails after Iconic Rock Songs by Grammy Award Winner Kenny Loggins 2Health News:Severe Hot Flashes During Menopause May Raise Hip Fracture Risk Later: Study 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 3
... by researchers at the University of Exeter Peninsula College of ... blood pressure between arms could be a useful indicator of ... findings add support to the calls for both-arm blood pressure ... published in The Lancet online today (30th January) ...
... HealthDay Reporter , THURSDAY, Jan. 26 (HealthDay News) -- A ... insight into whether patients are at high risk of a ... The test, which is currently available, could help ... the cancer from returning. There are caveats: The test ...
... 27, 2012 An itch is just an itch. Or ... professor of dermatology at Wake Forest Baptist Medical Center and ... itch feels is related to the itch,s location. While ... analysis of itch relief at different body sites and related ...
... News) -- Positive reinforcement, such as receiving small, unexpected ... to help patients with high blood pressure take their ... black Americans. The findings are significant because poor ... death, the researchers from the Center for Healthful Behavior ...
... HealthDay Reporter , THURSDAY, Jan. 26 (HealthDay News) ... and cervical cancers still fall below national targets, federal health ... were being screened for breast cancer, below the target of ... women, while the target is 93 percent, and for colon ...
... , THURSDAY, Jan. 26 (HealthDay News) -- New genetic ... menopause have been identified by an international team of ... a gene on a chromosome) linked with immune function ... menopause begins, said the researchers from the Boston University ...
Cached Medicine News:Health News:2-arm blood pressure check indicator for risk from heart disease or death 2Health News:Test Might Predict Risk of Lung Cancer's Return 2Health News:Body location plays part in scratching pleasure 2Health News:Positive Reinforcement May Help Patients Take Their Meds 2Health News:Too Few Americans Getting Screened for Common Cancers: CDC 2Health News:Too Few Americans Getting Screened for Common Cancers: CDC 3Health News:Factors Linked to Age of Onset of Menopause Identified 2
(Date:12/19/2014)... Ky. , Dec. 18, 2014 Baptist Health ... States to receive full Atrial Fibrillation with Electrophysiology ... Care (SCPC). Atrial fibrillation is the most common ... that in some cases can lead to stroke and possible ... United States have atrial fibrillation and the numbers ...
(Date:12/19/2014)... , Dec. 18, 2014   Aratana ... a biopharmaceutical company focused on the licensing, development ... today announced positive results from its pivotal field ... for treating pain in dogs with osteoarthritis.  In ... pain assessment scores that were statistically significant compared ...
(Date:12/19/2014)... separating membrane market has witnessed robust development with the ... as a later starter. In 2012, the size of ... billion, with the proportion worldwide soaring to 16.3%. It is ... will continue its growth rate by around 20% in the ... to roughly RMB25 billion. An integrated membrane industrial ...
Breaking Medicine Technology:Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3
... and PARIS, Feb. 24, 2011 /PRNewswire-Asia-FirstCall/ -- Sanofi-aventis (EURONEXT: ... it has completed the previously announced acquisition of BMP ... stockholders held today, BMP Sunstone stockholders approved the adoption ... Star 2010, Inc., a wholly owned subsidiary of sanofi-aventis, ...
... Conn., Feb. 24, 2011 Mira Dx announced today that ... acceptance of a pivotal breast cancer study in the January ... BRCA1 coding sequence mutations are associated with breast ... less than 5% of breast cancer risk. The research identified ...
Cached Medicine Technology:Sanofi-Aventis Announces Approval and Closing of BMP Sunstone Acquisition Creating a Strong Consumer Health Care Platform in China 2Mira Dx Licenses Triple Negative Breast Cancer Risk Variant from Yale University 2
... allows the user to quickly and accurately count ... digital counting or manual counting. An optional 1.5X ... magnification to 3.0X. The adjustable focusing rod allows ... lowered. The lens also rotates a full 360 ...
The Accucount 2000 is designed to automatically count microscopic objects in a field displaying totals on a highly visible digital readout....
The Accucount 1000 is designed to automatically count macroscopic objects in a field displaying totals on a highly visible digital readout....
... The CA-1000 counts a Petri dish ... on the optical characteristics of the colonies ... The CA-1000 is equipped with three types ... are lighter or darker than the agar ...
Medicine Products: