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Study shows drug effective in treating, preventing breast cancer
Date:11/1/2007

CORVALLIS, Ore. A new study of an estrogen-derived drug shows promise as a treatment for breast cancer and breast cancer metastases to bone.

The study, which was done in mice, appears on the cover of the November issue of Cancer Research.

Urszula Iwaniec, an assistant professor in the Department of Nutrition and Exercise Sciences at OSU, is the one of the authors of the study, along with OSU professor Russell Turner and researchers from the Mayo Clinic. Iwaniec and Turner are both researchers at OSUs Skeletal Biology Laboratory.

In breast cancer, the cancer commonly lodges in the bone, destroying it in a debilitating painful process called osteolysis. Osteolysis can lead to bone fractures and causes patients to feel tired, or even to lose consciousness.

Iwaniec and Turner studied the effect of 2-methoxyestradiol (meth-oxy-es-tra-di-ol), or 2ME2, on the bone. 2ME2 is derived from estrogen and works by suppressing tumor growth and blocking the formation of new blood vessels that feed tumors.

We were expecting the drug to have an effect, but we were not expecting to have as big of an effect as it did, Iwaniec said.

In studies of other cancers, 2ME2 has been shown to induce cancer cells to self-destruct. Otherwise, tumor cells evade this process allowing them to continually divide and spread throughout the body.

Clinical trials of 2ME2 for breast cancer patients are in progress. These trials are based on an oral version of 2ME2 to treat primary tumors, but this method has limitations as the oral version of 2ME2 is poorly suited to getting into the blood system and reaching tumors. Researchers resolved this problem by delivering 2ME2 by injection and found it was much more effective.

Researchers described 2ME2 as an attractive candidate for controlling tumor growth, metastasis to bone and bone disorders, such as osteolysis caused by the spread of breast cancer.

This is potentially
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Contact: Urszula Iwaniec
urszula.iwanie@oregonstate.edu
541-737-9925
Oregon State University
Source:Eurekalert

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