The research team examined the effects of a 24-month lifestyle weight-loss program in 301 overweight or obese participants with elevated fasting blood glucose, a common indicator of prediabetes. The study was conducted in and around Forsyth County, N.C., from 2007 through 2011 with the volunteers representing the racial composition of the county's population. Fasting blood glucose, insulin, insulin resistance, body weight, body mass index (BMI) and waist circumference were assessed every six months for 24 months.
Overweight and obese volunteers with elevated fasting blood glucose were assigned randomly to either a group-based, lifestyle weight-loss intervention (LWL) or an enhanced usual care comparison (UCC). The UCC was designed to exceed the usual care a person with prediabetes would typically receive, which might include a doctor advising a patient to lose weight and to exercise. In this study, the enhanced UCC provided participants with two meetings with a registered dietitian and monthly newsletters.
Results indicated that the significant reductions in body weight, BMI, waist circumference, fasting blood glucose, insulin and insulin resistance achieved during the first year of the program by the LWL group largely were maintained in the second year as compared to the usual care group. Additionally, at 24 months the percentage of volunteers who lost 5 percent or more of their initial body weight was 46.5 percent in the LWL group versus 15 percent in the UCC group.
"Many previous studies have shown that people can lose weight for six months, but maintaining those changes, particularly metabolic changes, over time is the real challenge," Katula said.
The study was limited in that participants were only from one county in North Carolina that included a mid-sized city. It is unknown whether this type of intervention can be implemented effectively in varying geographic locations involving various racial distribu
|Contact: Marguerite Beck|
Wake Forest Baptist Medical Center