Navigation Links
Study shows carvedilol is effective in preventing variceal bleeding in cirrhotic patients
Date:8/19/2009

Patients with cirrhosis are at risk for developing portal hypertension that can lead to the formation, dilation, and rupture of esophageal varices. The annual incidence of esophageal varices is approximately 5% and one third of those will bleed.

In a recent study, researchers from the University of Edinburgh determined carvedilol was more effective in the prevention of variceal hemorrhaging than variceal band ligation (VBL), a common treatment used for the past 20 years. The results of the first clinical trial to test carvedilol for prevention of variceal hemorrhage are available in Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

Dhiraj Tripathi and colleagues at the Royal Infirmary of Edinburgh enlisted 152 cirrhotic patients with grade II or larger esophageal varices that had not bled in this study. Researchers treated 77 patients with carvedilol, a non-cardioselective beta-blocker (NSBB) marketed under the trade name Eucardic (Roche), while 75 patients underwent VBL every two weeks until eradication. Patients were administered carvedilol orally at a starting dose of 6.25 mg per day, increasing to a target dose of 12.5 mg per day.

Results showed 10% of patients receiving carvedilol and 23% of patients treated by VBL experienced variceal bleeding during the follow-up period. There was no difference in survival rates between the two groups. "The greater efficacy of carvedilol in the prevention of the first variceal bleed is an important finding of this study," said Dr. Tripathi. "No other randomized trial has demonstrated drug therapy to have an advantage over VBL."

While researchers concluded carvedilol had greater effectiveness in treating portal hypertension than endoscopic therapy, there were limitations to their study. "Measurements of hepatic venous-pressure gradient (HVPG) were not included as part of the study, making it diff
'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Profiles International Releases New Study Identifying Key Factors for Strategic Workforce Planning
2. Thomson Reuters Study Finds Impact of Recession Easing on U.S. Hospitals
3. Retirees health-care benefits at risk, study warns
4. Lilly Reports on Outcome of Phase III Study of Arzoxifene
5. New study finds links between video-game playing and health risks in adults
6. Gen-Probe Begins U.S. Clinical Study of APTIMA(R) Trichomonas Vaginalis Assay on the TIGRIS(R) System
7. Study shows how to boost value of Alzheimers-fighting compounds
8. Low-income kids report first sexual intercourse at 12 years old in new national study
9. Excessive exercise can be addicting, new study says
10. New study expands the list of hazardous chemicals in smokeless tobacco
11. Summer heat increases risk of amniotic fluid level deficiency, Ben-Gurion University study reveals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... (PRWEB) August 28, 2014 ABC television ... the 49th MDA Show of Strength Telethon airing Sunday, ... country to help raise funds and awareness to help ... affected by muscle disease. , Viewers tuning into the ... enjoy heart-felt appeals and introductions from some of the ...
(Date:8/28/2014)... Allegheny Health Network and ... designed to advance sports nutrition education, concussion awareness ... scholastic athletes and their families across western Pennsylvania. ... Initiative will offer a comprehensive and multi-disciplined educational ... dynamics involved in pursuing athletic excellence,” said Come ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Gurnick Academy ... MRI Technology program is re-accredited for the 5 years ... Resonance Imaging Technologists (ARMRIT). , “We are very ... constantly improving our program to make sure we provide ... lot of interest in MRI field nowadays and I ...
(Date:8/28/2014)... problem in winemaking is "stuck fermentation," when yeast that ... carbon dioxide prematurely shuts down, leaving the remaining sugar ... the wine. , A team of researchers including UC ... communication system behind this problem. Working through a ... itself -- the system enables bacteria in fermenting wine ...
(Date:8/28/2014)... Tenn. The New England Journal of Medicine ... clinical trial of a drug shown to safely reduce ... volunteers intranasally infected with respiratory syncytial virus (RSV). ... of Tennessee Health Science Center researcher Infectious Disease Specialist ... , RSV is the most common cause ...
Breaking Medicine News(10 mins):Health News:ABC Stars Unite to Fight Back Against Muscle Disease During MDA Show of Strength Telethon 2Health News:ABC Stars Unite to Fight Back Against Muscle Disease During MDA Show of Strength Telethon 3Health News:ABC Stars Unite to Fight Back Against Muscle Disease During MDA Show of Strength Telethon 4Health News:Allegheny Health Network and Come Ready Nutrition Announce Regional Partnership 2Health News:Allegheny Health Network and Come Ready Nutrition Announce Regional Partnership 3Health News:Allegheny Health Network and Come Ready Nutrition Announce Regional Partnership 4Health News:Gurnick Academy’s MRI Program Is Re-Accredited by ARMRIT for the 5 Years 2Health News:Prions can trigger 'stuck' wine fermentations, researchers find 2Health News:DeVincenzo study breakthrough in RSV research 2
... in losing weights and are not healthy attempts to do ... Dieticians consulted by WebMD also agree and say that spending ... ,The growing rate of obesity in the United States ... the increasing childhood obesity. Cynthia Sass, MPH, MA, RD, LDN, ...
... families in North Carolina and Virginia found evidence of ... to call for pesticide safety training for workers’ spouses. ... from Wake Forest University School of Medicine report that ... pesticide exposure than had been found in similar studies ...
... those pills to beat the blues, just think positive instead. ... the key// to contentment lies in the mind and people ... from depression. ,D.V. Pasupuleti, director of neurology ... Michigan State University, believes anyone can create their own happiness ...
... pay compensation and apologise to a young woman orphaned by ... ,Beijing Chaoyang District Court ordered the local China Times ... and issue an apology on its front page for a ... of the woman and the story of her sufferings after ...
... According to the parliament's Health Select Committee the charges levied ... reviewed//. ,It pointed out to the fact that ... have any comprehensible underlying principles. Hence it concluded in its ... changed. These charges have a woeful effect on the patients ...
... region, Meghalaya Health mininster E D Marak was today hospitalised ... who returned from the Garo hills on Saturday, was admitted ... son told PTI., ,The Health minister had accompanied chief ... Garo Hills district town Tura., ,Malaria had claimed 40 ...
Cached Medicine News:Health News:Research Documents Children’s Exposure to Pesticide 2Health News:Inculcating Positive Thoughts Could Eliminate Depressive Mood 2
(Date:8/28/2014)... SALT LAKE CITY , Aug. 28, 2014 /PRNewswire-iReach/ ... in 2000 by service academy graduates, has published a ... its concentrated, three-day Leadership Excellence Course . In ... the  Leadership Excellence Course to Albuquerque , ... Tucson . Photo - http://photos.prnewswire.com/prnh/20140828/140814 ...
(Date:8/28/2014)... , August 28, 2014 ... "DNA diagnostics Market (products, applications, techniques, end users ... Growth and Forecast, 2013 - 2020," indicates that ... billion by 2020 registering a CAGR of 9.8% ... accurate diagnosis and cost effectiveness over alternative diagnostic ...
(Date:8/28/2014)... , Aug. 28, 2014   Venaxis, Inc. ... focused on obtaining FDA clearance for and commercializing its ... test for aiding in identifying children, adolescent, and young ... low risk for appendicitis, today announced it will present ... 16 th Annual Global Investment Conference being held ...
Breaking Medicine Technology:Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 2Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 3Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 4Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 5DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 3Venaxis to Present at September Investor Conferences 2Venaxis to Present at September Investor Conferences 3
... many benefits of fibre bronchoscopy: The HF-compatible ... which all other fibre bronchoscopes are measured., ... from PENTAX, including the FB-19TV, FB-18V and ... FB-10V and the pediatric FB-8V, offer much ...
... High performance fiberoptic imaging from the ... has improved its fiberscope range, focussing ... and enhanced image performance. Olympus has ... for diagnosis and therapy in the ...
Fujinon's standard fiberoptic bronchoscope is fully submersible and offers a large image for more comfortable and efficient observation....
... fiberoptic imaging from the latest 60 ... its fiberscope range, focussing on providing ... image performance. Olympus has a impressive ... and therapy in the respiratory tract ...
Medicine Products: