Navigation Links
Study shows bone fluoride levels not associated with osteosarcoma

Alexandria, VA, USA The International and American Associations for Dental Research have released in its Journal of Dental Research a study that investigated bone fluoride levels in individuals with osteosarcoma, which is a rare, primary malignant bone tumor that is more prevalent in males. Since there has been controversy as to whether there is an association between fluoride and risk for osteosarcoma, the purpose of this study, titled "An Assessment of Bone Fluoride and Osteosarcoma," was to determine if bone fluoride levels were higher in individuals with osteosarcoma.

No significant association between bone fluoride levels and osteosarcoma risk was detected in this case-control study, based on controls with other tumor diagnoses.

In the case-control study, by lead researcher Chester Douglass of Harvard University, patients were identified by physicians in the orthopedic departments from nine hospitals across the U.S. between 1993 and 2000. In this report, the study sample included incident cases of primary osteosarcoma and a control group of patients with newly-diagnosed malignant bone tumors. Specimens of tumor-adjacent bone and iliac crest bone were analyzed for fluoride content. The study was approved by the Institutional Review Boards of the respective hospitals, Harvard Medical School and the Medical College of Georgia.

Logistic regression of the incident cases of osteosarcoma (N=137) and tumor controls (N=51), adjusting for age and sex and potential confounders of osteosarcoma, was used to estimate odds ratios (OR) and 95% confidence intervals (CI). There was no significant difference in bone fluoride levels between cases and controls. The OR adjusted for age, gender, a history of broken bones was 1.33 (95% CI: 0.56-3.15).

"The controversy over whether there is an association between fluoride and risk for osteosarcoma has existed since an inconclusive animal study 20 years ago," said IADR Vice-president Helen Whelton. "Numerous human descriptive and case-control studies have attempted to address the controversy, but this study of using actual bone fluoride concentrations as a direct indicator of fluoride exposure represents our best science to date and shows no association between fluoride in bone and osteosarcoma risk."


Contact: Ingrid L. Thomas
International & American Associations for Dental Research

Related medicine news :

1. NIH awards WSU researcher $1.7 million to study non-alcoholic fatty liver disease
2. Speed Cameras Save Lives, Money: Study
3. Building Muscle May Reduce Diabetes Risk, Study Says
4. Cell Phones Dont Seem to Pose Cancer Risk to Kids: Study
5. Hepatitis Rates Soar Among IV Drug Users, Study Finds
6. Gene Study Sheds Light on Deadly German E. Coli Strain
7. 1 in 3 Nose Job Patients Has a Mental Illness: Study
8. Computer-Aided Mammography Doesnt Improve Breast Cancer Detection: Study
9. Big gap exists on health care spending between Latinos and whites, study finds
10. Age-Related Memory Loss May Be Reversible, Animal Study Suggests
11. Yoga boosts stress-busting hormone, reduces pain: York U study
Post Your Comments:
(Date:10/12/2015)... ... 2015 , ... The American Society of Clinical Hypnosis (ASCH) ... and clinical training in a health care discipline. , Many practitioners claim ... losing weight, managing pain, or stopping smoking, etc. Frequently, extravagant statements and guarantees ...
(Date:10/12/2015)... ... October 12, 2015 , ... AcousticSheep LLC, creators of ... in honor of Breast Cancer Awareness Month. During the month of October, ... a SleepPhones® Classic product to a breast cancer patient at the Cleveland Clinic. ...
(Date:10/12/2015)... ... October 12, 2015 , ... To help ... its charitable donation to the National Breast Cancer Foundation. The National Breast Cancer ... breast cancer through early detection, education, and support services. , The annual campaign ...
(Date:10/12/2015)... ... October 12, 2015 , ... NFL football fans who are interested in having an opportunity to ... CLICK HERE to donate to Smile for a Lifetime (S4L) Foundation and gift ... all-inclusive trip to the 2016 NFL Super Bowl! , Donors contributing $20.00 or more between ...
(Date:10/12/2015)... , ... October 12, 2015 , ... The translation for ... seamless migration of complete ARIS installations into the Microsoft world. The ARIS models ... As Microsoft Visio® is very familiar for both IT and Office users it is ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... October 12, 2015 ... Pipeline Review, H2 2015 market research report provides ... pipelines by identifying new targets and MOAs to ... . --> . ... spread across 62 pages, analyzing 6 companies, 8 ...
(Date:10/12/2015)... , Oct. 12, 2015 Device usage ... need to help integrate these devices into existing clinical ... ergonomic healthcare mounting and mobility solutions, has launched the ... cart yet, for a wide array of laptops and ... SV10 was developed exclusively for Microsoft Surface and is ...
(Date:10/12/2015)... 2015  Today, Divurgent is honored to announce Paul ... former CIO, Paul brings 15 years of hands-on experience as ... with today,s CIOs, he is one. The challenges that face ... faced, and his new role with Divurgent allows him to ... an organization. ...
Breaking Medicine Technology: