Navigation Links
Study shows antidepressant could do double duty as diabetes drug
Date:12/14/2012

University of Texas Medical Branch at Galveston researchers have discovered that the commonly used antidepressant drug paroxetine could also become a therapy for the vascular complications of diabetes.

The scientists made their discovery after screening 6,766 clinically used drugs and pharmacologically active substances.

"We developed this assay and used it to test literally every single existing drug and a good selection of other biologically active compounds," said UTMB professor Csaba Szabo, senior author of a paper on the research published online by Diabetes. "We were quite surprised when paroxetine came out as an active compound a result, we later determined, of what seems to be a completely new effect unrelated to its antidepressant actions and not shared by any other known antidepressant drug."

The initial screening process tested the ability of different compounds to protect the cells that make up the inner linings of blood vessels from the destructive effects of the high sugar levels produced by diabetes, known as hyperglycemia. In people with diabetes, hyperglycemia causes these endothelial cells to generate toxic molecules known as reactive oxygen species (ROS), which ravage blood-vessel linings and lead to diabetic endothelial dysfunction, the key factor in such destructive diabetic complications as heart attacks, strokes, retinopathy, nephropathy and neuropathy.

In subsequent test-tube studies, researchers found that paroxetine which is sold as an antidepressant under the trade name "Paxil" prevents hyperglycemia-initiated ROS damage to endothelial cells in two ways. First, it directly reduces concentrations of superoxide, a powerful ROS. Second, it suppresses superoxide production by mitochondria, tiny structures whose real job is making the energy-transfer molecules needed for most cellular processes. In a hyperglycemic environment, mitochondria are cells' biggest source of superoxide. According to
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... Nitrosigine®, a patented complex of bonded arginine silicate ... is hosting the Nitrosigine Pump Challenge at the America’s ... The Arnold Sports Festival in Columbus, Ohio. The event ... 2015. , Nitrosigine is a patented ingredient of ... status; now affirmed as GRAS.^ It has been clinically ...
(Date:3/4/2015)... The report “Vasculitis – Pipeline Review, H1 ... Vasculitis. Vasculitis is a disease that features tenderness of ... is not known. Vasculitis can affect any body system ... can include fever, weight loss, tiredness, aches, pains, night ... limb. Vasculitis is treatable, but it is not curable. ...
(Date:3/4/2015)... The week of March 2nd - 8th ... Awareness Day being recognized on March 13th, the aim ... risks associated with sleep related illnesses, costing the United ... of America have turned to social media with an ... virally inspire conversation regarding the disease. , The ...
(Date:3/4/2015)... California (PRWEB) March 04, 2015 ... a worrisome public health issue worldwide. The rising prevalence ... economic and social burden in both developed and developing ... is projected to rise to 1.5 billion, equating to ... of these patients are forecast to come from the ...
(Date:3/4/2015)... Bird B Gone, the leader in ... now offers its popular plastic (polycarbonate) bird spike in ... bird deterrent is ready-to-use and comes in ... décor of the building or structure onto which it ... clear, light grey, brown, black and tan—make the spikes ...
Breaking Medicine News(10 mins):Health News:Nitrosigine® Challenges Fitness Enthusiasts at The Arnold to Get Pumped 2Health News:Nitrosigine® Challenges Fitness Enthusiasts at The Arnold to Get Pumped 3Health News:Vasculitis Therapeutics Pipeline H1 2015 Review Report Available at RnRMarketResearch.com 2Health News:Vasculitis Therapeutics Pipeline H1 2015 Review Report Available at RnRMarketResearch.com 3Health News:Vasculitis Therapeutics Pipeline H1 2015 Review Report Available at RnRMarketResearch.com 4Health News:Innovative Sleep Apnea Procedure Could Save US Healthcare System Billions 2Health News:Innovative Sleep Apnea Procedure Could Save US Healthcare System Billions 3Health News:Innovative Sleep Apnea Procedure Could Save US Healthcare System Billions 4Health News:Aging Population Drives Demand for Blood Pressure Monitoring & Measurement Instruments, According to a New Report by Global Industry Analysts, Inc. 2Health News:Aging Population Drives Demand for Blood Pressure Monitoring & Measurement Instruments, According to a New Report by Global Industry Analysts, Inc. 3Health News:Aging Population Drives Demand for Blood Pressure Monitoring & Measurement Instruments, According to a New Report by Global Industry Analysts, Inc. 4Health News:Plastic Bird Spikes Now Come in 7 Colors to Blend in With Their Surroundings 2
... world-renowned fragile X syndrome researcher, who was the first ... disorder, will be honored by the March of Dimes. ... Timmie Professor of Human Genetics and Charles Howard Candler ... as professor of biochemistry and pediatrics at Emory University ...
... of persons who smoked 20 or more cigarettes per day declined ... smoking 10 or more cigarettes a day, with these declines greater ... a study in the March 16 issue of JAMA . ... in the United States, consumption was typically 1 pack (about 20 ...
... by a new type of self-monitoring blood glucose sensor being ... Clinic in Arizona. More than 23 million people in ... leading cause of death in the United States. It contributes ... lower extremity amputations and other chronic conditions. Many people ...
... University doctor should be studied and copied as a way to ... problem of adding 40 million people to its health care system ... Health Team Model (FHT) could help ease the burden. "What we ... and efficient way of providing health care," says Walter Rosser, professor ...
... technique has demonstrated that it can measure the interactions between ... other biological molecules. These extremely difficult measurements can aid the ... percent of the 7,000 proteins in a human cell reside ... 60 to 70 percent of the signals that control the ...
... 15, 2011Since the first laparoscopic procedure was performed to ... University in St. Louis, this breakthrough minimally invasive technique ... This remarkable achievement is celebrated with a series of ... peer-reviewed journal published by Mary Ann Liebert, Inc. ( ...
Cached Medicine News:Health News:Fragile X researcher honored by March of Dimes 2Health News:Prevalence of heavy smokers in US decreases 2Health News:Prevalence of heavy smokers in US decreases 3Health News:New device holds promise of making blood glucose testing easier for patients with diabetes 2Health News:New device holds promise of making blood glucose testing easier for patients with diabetes 3Health News:New laser technique opens doors for drug discovery 2Health News:20th anniversary of first laparoscopic nephrectomy 2
(Date:3/4/2015)... 4, 2015   InspireMD, Inc.  ("InspireMD" or the ... systems ("EPS"), today announced that it has entered into ... million shares of common stock and warrants to purchase ... in a public offering.  The common stock will be ... share, and each purchaser will receive a warrant to ...
(Date:3/4/2015)... Israël, 4 mars 2015 /PRNewswire/ ... (« RedHill » ou la « Société »), une ... sur les spécialités pharmaceutiques administrés ... stade clinique avancé pour les ... notamment les cancers gastro-intestinaux, a ...
(Date:3/4/2015)... -- ANI Pharmaceuticals, Inc. (NASDAQ: ANIP ) announced today ... at the Ritz-Carlton at Laguna Niguel, California ... Arthur S. Przybyl , President and CEO, will give the ... ANI,s website at www.anipharmaceuticals.com . Mr. Przybyl,s presentation will ... available through the link through June 7, 2015. ...
Breaking Medicine Technology:InspireMD Announces Public Offering for Approximately $13.5 Million 2InspireMD Announces Public Offering for Approximately $13.5 Million 3InspireMD Announces Public Offering for Approximately $13.5 Million 4RedHill Biopharma présentera à l'événement en ligne sur VirtualInvestorConferences.com le 5 mars 2015 2RedHill Biopharma présentera à l'événement en ligne sur VirtualInvestorConferences.com le 5 mars 2015 3RedHill Biopharma présentera à l'événement en ligne sur VirtualInvestorConferences.com le 5 mars 2015 4RedHill Biopharma présentera à l'événement en ligne sur VirtualInvestorConferences.com le 5 mars 2015 5ANI Pharmaceuticals To Present At 27th Annual ROTH Conference 2
... YORK, Jan. 12, 2011 NeoStem, Inc. (NYSE Amex: ... company with operations in the U.S. and China, today announced ... present on Wednesday, January 12, 2011 at the OneMedForum 2011 ... at 11:00 AM PST. Both events will be held in ...
... InstaCare Corp. (OTC Bulletin Board:  ISCR) a ... testing products for the chronically ill, a leading ... and a leading developer of revolutionary cell phone ... company,s Board of Directors has received the initial ...
Cached Medicine Technology:NeoStem to Present at Two Investor Conferences in San Francisco on Wednesday, January 12, 2011 2NeoStem to Present at Two Investor Conferences in San Francisco on Wednesday, January 12, 2011 3InstaCare Corp. Announces 2011 Genstrip Guidance Report Penned by William Walling, CFA 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: