Navigation Links
Study shows antidepressant could do double duty as diabetes drug
Date:12/14/2012

University of Texas Medical Branch at Galveston researchers have discovered that the commonly used antidepressant drug paroxetine could also become a therapy for the vascular complications of diabetes.

The scientists made their discovery after screening 6,766 clinically used drugs and pharmacologically active substances.

"We developed this assay and used it to test literally every single existing drug and a good selection of other biologically active compounds," said UTMB professor Csaba Szabo, senior author of a paper on the research published online by Diabetes. "We were quite surprised when paroxetine came out as an active compound a result, we later determined, of what seems to be a completely new effect unrelated to its antidepressant actions and not shared by any other known antidepressant drug."

The initial screening process tested the ability of different compounds to protect the cells that make up the inner linings of blood vessels from the destructive effects of the high sugar levels produced by diabetes, known as hyperglycemia. In people with diabetes, hyperglycemia causes these endothelial cells to generate toxic molecules known as reactive oxygen species (ROS), which ravage blood-vessel linings and lead to diabetic endothelial dysfunction, the key factor in such destructive diabetic complications as heart attacks, strokes, retinopathy, nephropathy and neuropathy.

In subsequent test-tube studies, researchers found that paroxetine which is sold as an antidepressant under the trade name "Paxil" prevents hyperglycemia-initiated ROS damage to endothelial cells in two ways. First, it directly reduces concentrations of superoxide, a powerful ROS. Second, it suppresses superoxide production by mitochondria, tiny structures whose real job is making the energy-transfer molecules needed for most cellular processes. In a hyperglycemic environment, mitochondria are cells' biggest source of superoxide. According to
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... Purity Products®, a leading direct to ... of their revolutionary new weight loss product, MuffinStop™. ... placebo-controlled clinical studies to be effective in reducing ... is a combination of two traditionally used botanical ... to create one of the most innovative weight ...
(Date:3/28/2015)... LTW Cyber is an innovation hub for ... purpose of addressing the needs of the global market ... opportunities to grow while seeking collaborative opportunities with the ... Ventures in LTW Cyber focus on secure application security, ... vulnerabilities and analyzing open source. As the hub ...
(Date:3/27/2015)... March 27, 2015 Wellness for Cancer–the ... business criteria for the spa and wellness industry–has certified ... who have experienced or are living with cancer. ... Wellness 365® Network, will be identified with a special ... a provider of safe, therapeutic services for cancer patients. ...
(Date:3/27/2015)... FL (PRWEB) March 27, 2015 Florida Hospital ... Storm as the team’s exclusive health care provider for the ... provider, Florida Hospital provides medical care and an athletic trainer ... Storm will kick off its season against the Cleveland Gladiators ... , “This partnership is extremely important to us as it ...
(Date:3/27/2015)... Texas (PRWEB) March 27, 2015 First ... 7am today. The new facility is located 12665 W Lake ... “As a resident of Summerwood, I look forward to delivering ... said Dr. Sowell, Facility Medical Director of First Choice Emergency ... Choice Emergency Room made a donation to Summer Creek High ...
Breaking Medicine News(10 mins):Health News:Purity Products Releases Revolutionary New Weight Loss Product, MuffinStop™ 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 2Health News:Canadian Cybersecurity Ventures Globalize as a Collective 3Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 3Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 4Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2
... teen’s online behavior associated with online interpersonal victimization. ... likely to become// victims of online harassment than ... Internet. The report was published in the February ... one of the JAMA/Archives journals. ,Online ...
... the February issue of Archives of General Psychiatry, one ... mental// illnesses are significantly more likely to die from ... those without mental illnesses. ,Physical health is ... to background information in the article. The adverse effects ...
... the composition of bacterial populations on the skins using a ... the largest organ in our body harbors many more new ... that it appears that the skin, is a kind of ... ,Researchers found evidence for 182 species of bacteria in ...
... they are more prepared than other doctors to hasten death ... futile,// reveals research published ahead of print in the Fetal ... ,The findings are based on an anonymous survey ... (neonatologists) across Australia and New Zealand. ,The ...
... Dutch study, high blood pressure during pregnancy could lead ... was conducted among 491// post-menopausal women. Among them, those ... a 57% chance of developing atherosclerosis than their counterparts ... which was published in the latest issue of ‘Hypertension’ ...
... worst hit by the flu pandemic, has stopped sharing human ... flu with foreign laboratories last// month. ,This was ... fight the highly pathogenic illness and to protect its intellectual ... International. ,The H5N1 virus has spread into ...
Cached Medicine News:Health News:Teens More Likely to Become Victims of Online Harassments 2Health News:Mentally Ill Have High Risk Of Cardiovascular Death 2Health News:Human Skin Harbors Many More Types of Bacteria 2Health News:Human Skin Harbors Many More Types of Bacteria 3Health News:Human Skin Harbors Many More Types of Bacteria 4Health News:Human Skin Harbors Many More Types of Bacteria 5Health News:Doctors’ Own Fear of Death Linked to Hastening Death of Very Sick Newborn 2
(Date:3/27/2015)... 27, 2015 Zimmer Holdings, Inc. (NYSE and SIX: ZMH) is ... ® Complete Knee System. , ... year since Zimmer first introduced the NexGen knee system, ... more than five million implantations of the NexGen knee have ... NexGen knee demonstrates the importance of design innovation and component ...
(Date:3/27/2015)... March 27, 2015 XRpro Sciences, Inc., ... discovery and development services which features high throughput ... industry, announced financial results for the year ended ...  Tyson, Chairman of XRpro Sciences commented, "We have ... from development stage to commercial stage in large ...
(Date:3/27/2015)... Report Details  New study shows ... What does the future hold for top companies ... new report shows you potential revenues to 2025, assessing ... 242-page report provides 185 tables, charts, and graphs. Discover ... future market prospects. Our new study lets you assess ...
Breaking Medicine Technology:Zimmer Celebrates Key Milestones For NexGen Complete Knee System 2XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 5Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 6Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 7
... 2011 The Consumer Healthcare Products Association (CHPA) ... North Carolina legislature passing a real-time, stop-sale system ... effective medicines containing pseudoephedrine (PSE), while stopping sales ... passage of a real-time, stop-sale system is a ...
... 2011 SmallCapVoice.com, Inc. announced today that ... Medical Equipment, Inc. (Pinksheets: SHOM), a holding ... durable medical equipment to medical institutions, is ... at http://smallcapvoice.com/blog/6-14-11-audio-interview-with-southern-home-medical-equipment-inc-pink-sheets-shom . SmallCapVoice ...
Cached Medicine Technology:A New Audio Interview With Jerry Overcash, Director for Southern Home Medical Equipment, Inc., is now at SmallCapVoice.com 2A New Audio Interview With Jerry Overcash, Director for Southern Home Medical Equipment, Inc., is now at SmallCapVoice.com 3
... Ultracompact high end desktop multilaser flow cytometer ... kind of cell analysis and absolute counting. ... and two different side scatter signals in ... The new CyFlow ML instrument can perform ...
This unique system combines the analytical power of a research cytometer into a compact, truly walk away, clinical analyzer ergonomically designed to expedite sample throughput....
This unique system combines the analytical power of a research cytometer into a compact, truly walk away, clinical analyzer ergonomically designed to expedite sample throughput....
The Elecsys 2010 Rack System streamlines processes and allows for smooth implementation of laboratory automation....
Medicine Products: