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Study shows antibiotic improves respiratory function in lung transplant patients
Date:5/23/2012

atory function, the researchers used a common lung function measurement called FEV1 (forced expiratory volume in the first second), which measures the volume of air (in millimeters, or ml) that can be forcibly exhaled in one second after taking a deep breath. By comparing patients' FEV1 values at the beginning of the study to FEV1 measurements made during the 12-week follow-up period, the researchers were able to determine if the patients' lung function had improved after being treated with azithromycin.

At the conclusion of their study, the researchers found that the patients who completed the study had a significant improvement in FEV1, with a mean difference of 358ml from baseline to 12 weeks; by comparison, patients in the placebo group experienced declines in their FEV1 measurements.

"Our randomized trial has confirmed that azithromycin improves lung function in patients with BOS following lung transplantation and this translates to improved survival for such patients," Dr. Corris noted. "There are ongoing studies trying to elucidate how the drug works which may well give clues to other potentially effective therapies."


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Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

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