Navigation Links
Study shows antibiotic improves respiratory function in lung transplant patients
Date:5/23/2012

ATS 2012, SAN FRANCISCO Researchers in the United Kingdom have determined that azithromycin, a broad-spectrum antibiotic that also has anti-inflammatory properties, can be an effective treatment option for patients suffering from bronchiolitis obliterans syndrome (BOS), a life-threatening complication that occurs in the majority of patients following lung transplantation.

BOS is the leading cause of mortality after the first year following transplantation, and occurs in part when the body repeatedly rejects the transplanted lung tissue. The syndrome causes the airways to become narrow and obstructed, resulting in a progressive decline in lung function and, eventually, respiratory failure. The exact full causes of the syndrome are unknown.

The study will be presented at the ATS 2012 International Conference in San Francisco.

The researchers evaluated the potential benefits of azithromycin, a type of antibiotic known as a macrolide, which works by inhibiting the ability of infection-causing bacteria to divide and replicate.

"In open studies, we and others have noted an improvement in lung function in BOS patients treated with macrolide antibiotics," said study lead author Paul Corris, professor of thoracic medicine at Newcastle University. "Other studies have not observed lung function gain with macrolide therapy, and there have been no randomized trials to date in patients with BOS."

"In this randomized study, we wanted to determine if patients treated with the antibiotic had improved lung function compared to patients who were treated with placebo," he said.

For their study, the researchers recruited 46 lung transplant patients with BOS and randomized them to receive either azithromycin (250mg on alternate days)or placebo. During the course of the study, 13 patients either withdrew or were withdrawn from the study; data from those individuals were included in a separate intent-to-treat (ITT) report.

To measure respiratory function, the researchers used a common lung function measurement called FEV1 (forced expiratory volume in the first second), which measures the volume of air (in millimeters, or ml) that can be forcibly exhaled in one second after taking a deep breath. By comparing patients' FEV1 values at the beginning of the study to FEV1 measurements made during the 12-week follow-up period, the researchers were able to determine if the patients' lung function had improved after being treated with azithromycin.

At the conclusion of their study, the researchers found that the patients who completed the study had a significant improvement in FEV1, with a mean difference of 358ml from baseline to 12 weeks; by comparison, patients in the placebo group experienced declines in their FEV1 measurements.

"Our randomized trial has confirmed that azithromycin improves lung function in patients with BOS following lung transplantation and this translates to improved survival for such patients," Dr. Corris noted. "There are ongoing studies trying to elucidate how the drug works which may well give clues to other potentially effective therapies."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... 27, 2016 , ... An educational campaign aimed at everyone ... courtesy of awareness-driven celebrities and thought leaders. It also provides insight to the ... leaders such as Bioness. , As patients feel increasingly concerned about the ...
(Date:5/27/2016)... , ... May 27, 2016 , ... ... scholarships to students studying complementary medicine. Allison Outerbridge is this year’s Life ... award on May 18 at the university’s Student Leadership Awards ceremony. , Outerbridge ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, ... defective respirators, according to court documents and SEC filings. A jury has ... Tyler v. American Optical Corporation, Case No. BC588866, Los Angeles County, California. The ...
(Date:5/26/2016)... ... 2016 , ... The Woodlands at John Knox Village , Florida’s first ... for living and healing, celebrated its grand opening, today. The Woodlands at John Knox ... by Empowered Staff. , “This is an incredibly fulfilling time for John Knox Village ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James Maisel will ... Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the Farmingdale Public ... Retina Group of New York , is a Board Certified ophthalmologist who ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016 ARANZ Medical  Ltd ... healthcare sector, has been named the Coretex Hi-Tech Emerging Company ... Dr Bruce Davey , CEO of ARANZ ...  It,s really good to be recognised for the work we ... are used in 35 countries around the world from Sub-Saharan ...
(Date:5/24/2016)... BioMarketing as senior vice president of sales, announced Andrea Heslin Smiley , VMS ... company,s business development and sales team, exploring new opportunities for VMS to empower patients ... ... ... ...
(Date:5/24/2016)... May 24, 2016 ... , la première endoprothèse à double ... à l,intervention portant sur les membres inférieurs ... OrbusNeich, entreprise mondiale spécialisée dans la ... la vie, a élargi son portefeuille pour ...
Breaking Medicine Technology: