Navigation Links
Study shows advance in using patients' own tumor-fighting cells to knock back advanced melanoma
Date:3/5/2012

SEATTLE A small, early-phase clinical trial to test the effectiveness of treating patients with advanced melanoma using billions of clones of their own tumor-fighting cells combined with a specific type of chemotherapy has shown that the approach has promise. One patient of the 11 experienced a long-term, complete remission that has lasted more than three years, and in four others with progressive disease, the melanoma temporarily stopped growing. The results of the study are published in the Early Edition of the Proceedings of the National Academy of Sciences for the week of March 5.

The goal of the research, led by Cassian Yee, M.D., a member of the Clinical Research Divison of Fred Hutchinson Cancer Research Center, was to find the optimum cellular environment in which to infuse 15 billion to 20 billion cancer-fighting CD8+ T cells so that they persisted for as long as possible in the body to battle the tumors. The cells, which were extracted from the patients and multiplied in the lab before re-infusion, are a type of white blood cell that attacks a protein associated with the cancer.

All of the patients in this study had progressive metastatic melanoma that no longer responded to traditional therapy. Prior to the T-cell infusions, all were treated with high doses of cyclophosphamide to eradicate their lymphocytes, a type of white blood cell that is part of the immune system. This was done to stimulate the production of certain growth factors that help promote further expansion of the T cells within the body.

Eight of the 11 patients received low doses of interleukin-2 growth factor after the T cells were infused to further promote cell growth. Among these patients, one showed a complete remission and four patients, who had failed conventional therapy, experienced a temporary non-progression of their disease. The remaining three patients received higher doses of IL-2, which was found to be more toxic to the body. Two of the
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... California (PRWEB) May 19, 2013 Grinding ... than just losing sleep, or annoying your spouse. At ... report by CNY Central (“Snoring and Teeth Grinding Could ... type of teeth grinding can be hard to prevent. ... million Americans, and one of its symptoms is a ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 According ... Market Analysis and Forecast (2013 – 2018): By ... Defense, Industrial)); Technology (CCD, CMOS, Contact IS, Infrared, ... of image sensor market was $8.00 billion in ... in 2018, at an estimated CAGR of 3.84% ...
(Date:5/19/2013)... 6Webs.com is the leader in reviews ... are considering an alarm system can do a comparison ... security system providers online at 6Webs.com. Just recently finishing ... home security system companies, 6Webs.com currently is announcing ... home security companies before ranking the home security system ...
(Date:5/19/2013)... These molecular diagnostics market reports ... Japan, Italy, Germany and France:, ... practice, as well as key economic, regulatory, demographic, ... during the next five years. ,     An ... test formats, detection methodologies, trends in testing automation ...
(Date:5/19/2013)... 19, 2013 The report “Feed Additives ... & Forecasts up to 2017” published by MarketsandMarkets, defines ... analysis and forecasting of the global volume and revenue ... driving and restraining factors for the global market with ... challenges. The market is segmented and revenue is forecasted ...
Breaking Medicine News(10 mins):Health News:Dr. Kanani, Woodland Hills Dentist: Dangers of Tooth Damage and Obstructive Sleep Disorder 2Health News:Dr. Kanani, Woodland Hills Dentist: Dangers of Tooth Damage and Obstructive Sleep Disorder 3Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 2Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 3Health News:Top Rated DIY Home Security System Companies Published by 6Webs.com 2Health News:Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com 2Health News:Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com 3Health News:Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com 4Health News:Feed Additives Market to Reach $19.5 Billion by 2017 at a CAGR of 3.8% - New Report by MarketandMarkets 2Health News:Feed Additives Market to Reach $19.5 Billion by 2017 at a CAGR of 3.8% - New Report by MarketandMarkets 3
... sex with an infected partner, adolescent girls have a 1% ... herpes . ,Britain is facing a major teen sex ... (STIs) and high levels of teenage pregnancy in the UK ... enhance sexual activity, Independent Advisory Group (IAG) on Sexual Health ...
... Researchers at the Salk Institute for Biological Studies have found ... kind humans experience in everyday life, may contribute to ... a hallmark of Alzheimers disease. ,The researchers say ... Alzheimers disease, a number of studies have pointed to stress ...
... in patients with rheumatoid arthritis (RA) is significantly reduced ... first trimester to the third trimester of the participants ... ,This is the first prospective study ... 124 female RA patients throughout their pregnancy and at ...
... ruled that Ontario residents can get cold and allergy ... . ,The Ontario Superior Court has overturned ... Ontario College of Pharmacists preventing grocers from selling medications ... and Benadryl. ,The original decision was made ...
... the University at Buffalo conducted a content analysis of newspaper ... results for organ donation. ,In a study ... results showed that 57 percent of the articles were positive ... were neutral. ,"Research has shown that most of ...
... or more of oral steroid treatment decreases the risk of ... were found regardless of when in the course of the ... were not observed if the steroids were taken for less ... of corticosteroid treatment in rheumatoid arthritis have been a subject ...
Cached Medicine News:Health News:UK Facing Major Sexual Health Crisis Among Teens 2Health News:UK Facing Major Sexual Health Crisis Among Teens 3Health News:Emotional Stress Could Be a Factor in Causing Alzheimers: Study 2Health News:Intensity of Rheumatoid Arthritis Significantly Reduced by Pregnancy 2Health News:Canadian Court Rules Grocery Shops can Sell Cold Medications Containing Pseudoephedrine 2Health News:Newspaper Analysis positive Results for Organ Transplantation 2Health News:Long-term Oral Steroid Therapy Decreases Lymphoma Risk in Rheumatoid Arthritis 2
(Date:5/19/2013)... Fla. , May 19, 2013  The ... and low temperature radiofrequency (RF) energy is effective ... eliminates or reduces the need for medication 10 ... assessment presented today at the Digestive Disease Week ... Orlando, Florida . "The ...
(Date:5/18/2013)... 18, 2013 Although colonoscopy exams prevent many ... most sensitive method for detecting colorectal cancers 2 , ... cases 3 . EndoChoice ® Inc. today unveiled ... improves the accuracy of this procedure and greatly reduces ... be discussing these clinical trial results and featuring the ...
(Date:5/18/2013)... SAN FRANCISCO , May 18, 2013 /PRNewswire-USNewswire/ ... MadinAmerica.com , Occupy Psychiatry ... reform mental health care, announces a social media ... by the traditional psychiatric model, which focuses on ... The launch coincides with the American Psychiatric Association,s ...
Breaking Medicine Technology:Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 2Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 3New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 2New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 3New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 2New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 3
... WALTHAM, Mass. , May 20 Inverness Medical ... enabling individuals to take charge of their health at home through ... it will attend the Citi Global Health Care Conference being held ... Hilton Hotel in New York City .  Jon Russell, Vice ...
... DALLAS , May 20 As part of its ongoing commitment ... announced that it will be one of the sponsors of the Living for ... Country Club in Plano, Texas . , ... The Living for Zachary golf event is named for 16-year-old Plano ...
Cached Medicine Technology:HeartSine Technologies Supports 'Living for Zachary' Benefit Golf Tournament 2HeartSine Technologies Supports 'Living for Zachary' Benefit Golf Tournament 3
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... • BTN/1Q-CAB chairs are recommended for ... clean room, static control, health care ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTN/1Q-CAB chairs are recommended for the ... room, static control, health care and ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
Medicine Products: