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Study shows additional role for abiraterone in blocking tumor growth in CRPC
Date:3/15/2013

Arnhem, 14 March 2013 - As part of an EU-supported IMI-PREDECT consortium (http://www.predect.eu), a Dutch study showed that anti-androgenic properties of the drug abiraterone may provide an additional mechanism of action in blocking tumour growth of castration resistant prostate cancer (CRPC).

The study, which won the first prize for best abstract in oncology at the 28th European Association of Urology (EAU) Congress to be held in Milan from March 15 to 19, demonstrated that although the use of abiraterone can potentially lead to an accumulation of precursor hormones, its anti-androgenic properties may stop precursor hormone-induced androgen receptor (AR) activation.

"Our results show that high concentrations of androgen precursors can drive CRPC growth through direct activation of (overexpressed) AR and not necessarily via the result of (intratumoural) CYP17-metabolism. This suggests that CRPC may not rely solely on de novo androgen synthesis," said lead author Dr. Jan Matthijs Moll of the Erasmus Medical Center, Dept. of Urology in Rotterdam, Netherlands.

Men with castration resistant prostate cancer are a difficult group to treat. Although metastatic prostate cancer may respond well to androgen ablation therapy initially, castration resistance usually develops within three years. Even though circulating testosterone levels are low in these patients, the androgen receptor reactivates, which indicates the AR remains an important target in CRPC.

The Rotterdam-based group has previously demonstrated that conversion of adrenal androgens into testosterone, rather than intratumoural de novo steroidogenesis, is the major source of testosterone in CRPC tumours. [1]

Clinical trials have demonstrated that abiraterone acetate plus prednisone/prednisolone can increase survival in CRPC patients even after chemotherapy [2]. "Blocking androgen synthesis (pregnenolone and proges
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Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

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