Navigation Links
Study shows SBRT for stage I NSCLC safe and effective
Date:7/1/2013

DENVER Stereotactic body radiotherapy (SBRT) is considered the treatment of choice for early-stage nonsmall-cell lung cancer (NSCLC) if patients are inoperable because of additional medical conditions. This is based on several prospective phase II trials, which reported consistently high rates of local tumor control. However, these studies only included small number of patients, the methodology of SBRT varied between the studies and SBRT was mainly practiced in specialized centers. Therefore, safety and efficacy of SBRT practiced in routine clinical practice outside of study protocols is not well analyzed.

A working group called Extracranial Stereotactic Radiotherapy was formed within the German Society for Radiation Oncology and this group performed a patterns-of-care and patterns-of-outcome analysis looking at safety and efficacy of SBRT for stage I NSCLC in Germany and Austria. Their research, published in the August issue of the Journal of Thoracic Oncology (JTO), concludes SBRT for stage I NSCLC was safe and effective in this multi-institutional environment. In addition, radiotherapy dosage was identified as a major treatment factor influencing local tumor control and overall survival.

The researchers looked at data from 582 patients treated at 13 institutions between 1998 and 2011. Average follow-up for all patients was 21.4 months and the maximum was 144 months (12 years); follow-up was more than 3 years for 108 patients. Three-year freedom from local progression was 79.6 percent for all 582 patients.

The biological effective dosage was the most significant factor influencing freedom from local progression and overall survival. No evidence of a learning curve or improvement of results with larger SBRT experience and implementation of new radiotherapy technologies was observed. The group concluded that SBRT for stage I NSCLC was safe and effective in this multi-institutional, academic environment, despite considerable inter-institutional variability and time trends in SBRT practice.


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. Study links cardiac hormone-related inflammatory pathway with tumor growth
2. How to boost Hispanics participation in clinical trials? Relate to them, Moffitt study shows
3. Impact of iPad® on radiology residents daily clinical duties is limited, study suggests
4. New study on popular prostate cancer protein provides insight into disease progression
5. Study finds dramatic increase in hospitalization of US children with inflammatory bowel disease
6. GAP-AF study helps to define optimal approach to ablation
7. New Study: Alcohol Drinkers May Face Long Term Health Issues
8. A Study Shows That Mom’s Obesity Surgery May Help Break Cycle in Obese Kids
9. New Study Casts Doubt on FDA Pradaxa Conclusions
10. Results of landmark 11-year study on weight losss effect on heart disease risks published today
11. Rottenstein Law Group LLP Acknowledges BMJ Study of Risks of Byetta, Januvia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. ... 217 Portion Road in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine ... visits to the dentist fit into their patients’ busy lifestyles. Dental365 also gladly ...
(Date:6/23/2017)... ... 2017 , ... "The Better Care Reconciliation Act (BCRA) falls ... people with all chronic conditions, including mental illnesses, while increasing the cost of ... Care Act (ACA) requirement that insurers cover pre-existing conditions, it does not require ...
(Date:6/23/2017)... ... 2017 , ... The Military Officers Association of America (MOAA) announced its support ... retired Marine Col. Thomas G. Bowman. , Bowman currently serves as the staff director ... with the issues and challenges veterans face with the VA. Following a 30-year career ...
(Date:6/23/2017)... ... June 23, 2017 , ... Goodcents Deli Fresh Subs today announced the opening ... 4210 SW 21st St. Topeka, Kan. 66604 (near 21st and Gage). It is owned ... owns three other locations in the Topeka and Bonner Springs, Kan. area. , ...
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and South ... selected 21 leaders from government, business and civil society in 11 countries across the ... this fall, engaging in a transformative exchange of knowledge and ideas with the leading ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)...  Diplomat Specialty Infusion Group, a brand of Diplomat Pharmacy, Inc. ... Iowa location. The Iowa ... an ISO 7 cleanroom—the standard needed to compound intravenous (IV) nutrition ... of pollutants. "Our new cleanroom ... serve our Iowa patients," said Phil ...
(Date:6/1/2017)... 2017 Nutriceutical Holdings (NH), parent company of ... and KD Pharma Group have decided to join forces ... Pharma Group. KD Pharma Group will become the largest ... the entire company. "We believe we have ... to growing the NH companies by providing us with ...
(Date:5/26/2017)... 2017  Endo International plc (NASDAQ: ENDP ) ... will represent the Company in a fireside chat at Goldman ... June 13, 2017 at 10:40 a.m. PT / 1:40 p.m. ... Rancho Palos Verdes, CA. ... be available on the Company,s website at http://www.endo.com/investors/overview . ...
Breaking Medicine Technology: