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Study shows PRP, commonly used technique to improve healing, doesn't work in rotator cuff surgery
Date:2/18/2011

hloride to make a gummy substance that they could implant in the patient. "It is essentially a material that can be actually sutured in at the time of surgery. It's almost like chewing gum in consistency," Dr. Rodeo said. "In rotator cuff repair, we attached it to a suture which was used to reattach the tendon to the bone." The substance is then supposed to stimulate healing.

In the prospective, patient-blinded trial, 79 patients were randomized to rotator cuff surgery with or without an implant of PRFM. Patients in both groups received the same rehabilitation after surgery. The primary end point of the study was tendon healing evaluated by ultrasound at 6 to 12 weeks. Investigators also analyzed shoulder outcome scales and strength measurements. Overall, there was no difference in tendon-to-bone healing between the PRFM and the control group. There were also no significant differences in the shoulder outcome scales between groups. If any difference was identified, it was slightly negativepatients in the PRFM group showed more tendon defects at 12 weeks, although the difference was not statistically significant.

"There are a number of variables that we need to better control including dosing and timing," Dr. Rodeo said. He pointed out that only one injection was used in the study and that perhaps repeat injections are needed.

He also said that a major issue that needs tackling is the variability in how PRP is made. "The bigger issue is that there is a lot of variability from patient to patient. There are inter-individual variations, potentially huge variations in my platelet count versus your platelet count and how many proteins are in my cells versus your cells," Dr. Rodeo said. He said studies are needed to shed light on how this affects the product that is produced.

"Before this study, we knew that platelets had the potential to improve healing and now we know that in the dose and the type used in this study that it did not h
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Contact: Phyllis Fisher
phyllis.fisher@gmail.com
212-606-1197
Hospital for Special Surgery
Source:Eurekalert

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