Navigation Links
Study shows PET can measure effectiveness of novel breast cancer treatment
Date:7/2/2009

er, these samples may not represent the overall characteristics of the tumor and may not accurately estimate HER2 expression. In addition, there are currently no means to evaluate how long a therapeutic agent takes to affect the targeted tumors and how long the effects last.

In the study, researchers attached the radioactive nuclide flourine-18 to an HER2-binding variant of a small protein known as an Affibody molecule. PET scans can detect the Affibody compound and allow researchers to visualize breast cancer tumors with HER2 protein in mice. These molecules can also be engineered to specifically bind to other targets for cancer diagnosis and therapy.

The researchers implanted human breast cancer cellsexpressing either very high or high levels of HER2under the skin of mice to show that this method of imaging can be used to monitor changes in HER2 expression after treatment. Researchers then intravenously injected the HER2-targeting Affibody compound and performed PET imaging three to five weeks after tumors had formed. Four doses of the drug 17-DMAG were administered, which decreases HER2 expression, spaced 12 hours apart. PET scans were performed before the treatment and after each dose.

The researchers found that HER2 expression was reduced by 71 percent in mice bearing tumors with very high levels of HER2 protein and by 33 percent in mice bearing tumors with high levels of the protein, compared to the levels measured before treatment and to tumors that did not receive the treatment. Researchers confirmed their data using established laboratory techniques to determine the concentrations of HER2 proteins in the same tumors after they were removed from the mice.


'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Study Shows Many Unplanned Quit Smoking Attempts are Successful
2. Study examines dietary influences of liver disease
3. Study examines liver transplantation after drug induced acute liver failure
4. Study Supports Wider Use of Statins
5. Study identifies biomarker that safely monitors tumor response to new brain cancer treatment
6. The European Association for the Study of the Liver renews publishing partnership with Elsevier
7. Study to see if video games can boost thinking skills in elderly
8. GIE: Gastrointestinal Endoscopy June issue study highlights
9. Study shows 1 in 25 deaths worldwide attributable to alcohol
10. Veterans Affairs Researchers Study Benefits of Robot for Ankle Rehabilitation
11. U-M study finds voice box can be preserved, even with the largest cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... 2014 According to a new market ... (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - Global ... the global endoscopy devices market was valued at USD ... at a CAGR of 6.8% from 2013 to 2019, ... in 2019. , Endoscopy procedures are performed by inserting ...
(Date:7/27/2014)... Prominent Vancouver Chiropractors, Dr. Shervin Ranjbar and ... hamstring release procedure in Vancouver, BC. Both these chiropractors ... and have years of experience in the field of ... by the two professionals using a foam roller exercise. ... release tight hamstrings and relieve the client of the ...
(Date:7/27/2014)... The report, “Oil Filter & Fuel Filter ... Market Type (OE & Aftermarket), Filter Type (Oil & ... Industry Trends & Forecast to 2018”, defines and segments ... analysis and forecasting of the global volume and revenue. ... reach a revenue of $6.1 billion in 2018, while ...
(Date:7/27/2014)... The report provides market analysis ... Market Analysis (Commercial Aviation And Defense Aviation Landing ... - Forecasts 2014 - 2019." The report covers ... shape the market during the study period. It ... that are currently prevailing in the global market. ...
(Date:7/27/2014)... Australia (PRWEB) July 27, 2014 ... in Australia is restricted to two companies, heavy ... to IBISWorld industry analyst Spencer Little, “Demand for ... due to rising health concerns, frequent anti-smoking campaigns, ... result, industry revenue is estimated to fall at ...
Breaking Medicine News(10 mins):Health News:Global Endoscopy Devices Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Health News:Global Endoscopy Devices Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Health News:Global Endoscopy Devices Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4Health News:Renowned Vancouver Chiropractors Demonstrates Hamstring Release in Vancouver, BC 2Health News:Oil Filter & Fuel Filter Market Worth $18.6 Billion by 2018 - Report by MarketsandMarkets 2Health News:Oil Filter & Fuel Filter Market Worth $18.6 Billion by 2018 - Report by MarketsandMarkets 3Health News:Oil Filter & Fuel Filter Market Worth $18.6 Billion by 2018 - Report by MarketsandMarkets 4Health News:Oil Filter & Fuel Filter Market Worth $18.6 Billion by 2018 - Report by MarketsandMarkets 5Health News:Actuator Systems Market in Aviation Estimated to Reach $3,839.74 Million by 2019 - New Report by MarketsandMarkets 2Health News:Actuator Systems Market in Aviation Estimated to Reach $3,839.74 Million by 2019 - New Report by MarketsandMarkets 3Health News:Actuator Systems Market in Aviation Estimated to Reach $3,839.74 Million by 2019 - New Report by MarketsandMarkets 4Health News:Cigarette and Tobacco Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Cigarette and Tobacco Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Cigarette and Tobacco Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4
... lost their limbs due to disease, accident or disasters like ... Jakarta//. ,"On the invitation of a non-resident Indian association, ... in which 350 people will be fitted with the Jaipur ... Sahayta Samiti in Jaipur, told IANS here. ...
... our weight or a bad hair day is common ... spend// nearly every waking moment--up to 80 to 90 ... professionals with the Eating Disorders Program at The Menninger ... concern with body shape and size that is a ...
... Administration ordered the makers of ADHD drugs to indicate the ... psychiatric and cardiovascular risks. ,Dr. Steven Galson, director ... that although these drugs are immensely useful in treating patients ... the public. He also said that FDA is working ...
... Age-related macular degeneration (AMD) is the leading cause of ... affecting// more than two million people. ... that although AMD is incurable, there are new treatments ... vision loss from the disease. ,The Academy ...
... safe and healthy multivitamin? Vitamins and Minerals: What You ... School//, offers the following advice. ,Look for ... U.S. Pharmacopeia Dietary Supplement Verification Program (USP-DSVP) mark, which ... ,Consider safe levels. All dietary supplements ...
... has immensely deteriorated over the last seven years and married ... said Wednesday. ,According to the National Family Health ... group between 15 and 49 were anemic in 2006 as ... deficiency of red blood cells, which can lead to a ...
Cached Medicine News:Health News:Indonesians to Be Fitted Jaipur-made Artificial Limbs 2Health News:Improving Body Image Key to Treating Eating Disorders 2Health News:Improving Body Image Key to Treating Eating Disorders 3Health News:Spring is Time for Age-Related Macular Degeneration (AMD) Awareness 2Health News:Married Women, Children Most Anemic in India 2
(Date:7/24/2014)... PARK, Kan. , July 24, 2014 /PRNewswire/ ... of two compounds that will be added to ... with Australian-based CIMTECH Pty Ltd, a biotechnology company. ... PAR 122 have shown promise in bone regeneration ... license to develop the compounds for the veterinary ...
(Date:7/24/2014)... , Deutschland, und MARSEILLE ... -- , Weltweite ... ermöglicht QIAGEN die Entwicklung von Tests ... für Blutkrebs  Neuer Test weist ... mit Knochenmarkserkrankungen (myelodysplastischen Syndromen) einen günstigen Krankheitsverlauf ...
(Date:7/24/2014)... Calif., July 24, 2014  Abaxis, Inc. (NasdaqGS: ... blood analysis systems, today reported financial results for the ... First quarter overview: , Revenues of $47.5 million, ... Diluted EPS of $0.21, up 50% over last year,s ... market revenues of $7.2 million, up 20% over last ...
Breaking Medicine Technology:Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 2Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 3Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 4QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 2QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 3QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 4QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 2Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 3Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 4Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 6Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 7Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 8Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 9Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 10Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 11
... (NYSE: LMT ) has completed its acquisition of ... is the largest provider of outsourced medical evaluation services to ... 450,000 evaluations last year. Founded in 1981, ... to the Department of Defense, the VA and other U.S. ...
... BRUNSWICK, N.J., Sept. 27, 2011 Bluestar Silicones Senior ... to Control Bacterial Growth" at the upcoming Medical Silicones ... Dr. Hoy, the rising number of hospital acquired infections, ... are factors that contribute to growing demand for medical ...
Cached Medicine Technology:Bluestar Silicones to Present Antimicrobial Silicones at Medical Silicones Conference in Boston 2
... Monarc Subfascial Hammock™ is a minimally ... suffering from stress urinary incontinence (SUI). ... the urethra during abdominal stress events, ... Monarc's outside-to-in transobturator approach avoids the ...
... Proven tension-free sling technology ... porcine acellular collagen matrix sling, ... tissue-to-tissue contact between sling and ... urethral or vaginal abrasion or ...
... Delivers the advanced performance ... exceptional strength, versatility, and durability ... implant that augments the effectiveness ... pelvic floor reconstruction. Comprised of ...
... Q-Tel RMS system is a state-of-the-art, ... system. Its programs, modalities, and parameters ... support for multiple applications including cardiac ... heart failure clinics. Its open architecture ...
Medicine Products: