Navigation Links
Study shows PET can measure effectiveness of novel breast cancer treatment
Date:7/2/2009

er, these samples may not represent the overall characteristics of the tumor and may not accurately estimate HER2 expression. In addition, there are currently no means to evaluate how long a therapeutic agent takes to affect the targeted tumors and how long the effects last.

In the study, researchers attached the radioactive nuclide flourine-18 to an HER2-binding variant of a small protein known as an Affibody molecule. PET scans can detect the Affibody compound and allow researchers to visualize breast cancer tumors with HER2 protein in mice. These molecules can also be engineered to specifically bind to other targets for cancer diagnosis and therapy.

The researchers implanted human breast cancer cellsexpressing either very high or high levels of HER2under the skin of mice to show that this method of imaging can be used to monitor changes in HER2 expression after treatment. Researchers then intravenously injected the HER2-targeting Affibody compound and performed PET imaging three to five weeks after tumors had formed. Four doses of the drug 17-DMAG were administered, which decreases HER2 expression, spaced 12 hours apart. PET scans were performed before the treatment and after each dose.

The researchers found that HER2 expression was reduced by 71 percent in mice bearing tumors with very high levels of HER2 protein and by 33 percent in mice bearing tumors with high levels of the protein, compared to the levels measured before treatment and to tumors that did not receive the treatment. Researchers confirmed their data using established laboratory techniques to determine the concentrations of HER2 proteins in the same tumors after they were removed from the mice.


'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Study Shows Many Unplanned Quit Smoking Attempts are Successful
2. Study examines dietary influences of liver disease
3. Study examines liver transplantation after drug induced acute liver failure
4. Study Supports Wider Use of Statins
5. Study identifies biomarker that safely monitors tumor response to new brain cancer treatment
6. The European Association for the Study of the Liver renews publishing partnership with Elsevier
7. Study to see if video games can boost thinking skills in elderly
8. GIE: Gastrointestinal Endoscopy June issue study highlights
9. Study shows 1 in 25 deaths worldwide attributable to alcohol
10. Veterans Affairs Researchers Study Benefits of Robot for Ankle Rehabilitation
11. U-M study finds voice box can be preserved, even with the largest cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... The North America Artificial lift market report defines ... analysis and forecast of revenue. The artificial lift market in ... in 2013 to around $7 billion by 2018, at a ... through the TOC of North America artificial lift market report, ... provides a glimpse of the segmentation in North America Artificial ...
(Date:7/25/2014)... July 25, 2014 Agoura Hills dentist ... on Zoom Whitening. Zoom Whitening is one of the most ... through a dental professional. This light-assisted treatment uses a prescription-strength ... of the tooth to break up stains that are in ... coffee, tea, wine, soft drink and tobacco stains. , ...
(Date:7/25/2014)... The rising pharmaceutical sale across the US ... of the US PBM industry. A slow but steady increase ... sales in the US over the past few years. The ... in the prescription volume over the past few years. , ... 2013 Edition” the demand for the pharmacy benefit managers in ...
(Date:7/25/2014)... July 25, 2014 Ross A. Clevens, ... been invited to join the exclusive Obagi Clinical Advisory ... facial plastic surgeons, plastic surgeons and dermatologists. , ... exclusive Advisory Board of thought leaders held its first ... meeting was to give Obagi the opportunity to meet ...
(Date:7/25/2014)... 25, 2014 (HealthDay News) -- Dietary changes can dramatically ... a daily basis, according to a new study. ... might help detect and ease flare-ups for people with ... colitis and Crohn,s disease), the researchers said. Trillions ... effect on human health isn,t well understood, the Massachusetts ...
Breaking Medicine News(10 mins):Health News:North America Artificial Lift Services Market is Expected to Reach $7 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:North America Artificial Lift Services Market is Expected to Reach $7 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:North America Artificial Lift Services Market is Expected to Reach $7 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Agoura Hills Dentist, Dr. Amir Choroomi, is Now Offering a Promotion on Zoom Whitening 2Health News:US Pharmacy Benefit Management (PBM) Market Trends and Developments Now Available at MarketReportsOnline.com 2Health News:US Pharmacy Benefit Management (PBM) Market Trends and Developments Now Available at MarketReportsOnline.com 3Health News:Renowned Melbourne Plastic Surgeon to Join Private Medical Advisory Board 2Health News:Diet Changes Can Alter Gut Bacteria, Study Says 2
... MONDAY, March 7 (HealthDay News) -- Genetics may predispose some ... and stress are a fact of daily life -- to ... warns. The culprit is a specific abnormality of the ... gene is known to play a key role in the ...
... March 7, 2011 Embargoed by the journal ... time Working as part of a public program to ... useful molecules, scientists from The Scripps Research Institute and ... potent class of potential anti-cancer and anti-neurodegenerative disorder compounds. ...
... it won,t be obvious to UCSF Medical Center patients, behind ... processes their medications. With a new automated hospital pharmacy, believed ... technology and electronics to prepare and track medications with the ... error has occurred in the 350,000 doses of medication prepared ...
... of recognizing tumor growth, and naturally mounts an anti-cancer ... (antigens) and present them to T cells, and those ... kill tumor cells. In recent years, researchers have attempted ... new therapies- namely, by generating a pool of tumor ...
... Transplanting stem cells derived from umbilical ... offer future therapeutic benefit for those suffering from ... says a team of neuroscience researchers from the ... Brain Repair and collaborators from three private-sector research ...
... Reinberg HealthDay Reporter , SUNDAY, March 6 (HealthDay ... a safe way to detect Down syndrome during pregnancy, researchers ... identified a gene mutation associated with Down syndrome with 100 ... is a common birth defect, with one Down syndrome birth ...
Cached Medicine News:Health News:Mix of Genetics and Stress Can Impair Mental Abilities 2Health News:Scripps Research and MIT scientists discover class of potent anti-cancer compounds 2Health News:Scripps Research and MIT scientists discover class of potent anti-cancer compounds 3Health News:Scripps Research and MIT scientists discover class of potent anti-cancer compounds 4Health News:New UCSF robotic pharmacy aims to improve patient safety 2Health News:New UCSF robotic pharmacy aims to improve patient safety 3Health News:Transplanting umbilical cord and menstrual blood-derived stem cells offer hope for disorders 2Health News:Transplanting umbilical cord and menstrual blood-derived stem cells offer hope for disorders 3Health News:Transplanting umbilical cord and menstrual blood-derived stem cells offer hope for disorders 4Health News:Noninvasive Test May Identify Down Syndrome Early On 2
(Date:7/24/2014)... HILDEN , Deutschland, und ... , ... ermöglicht QIAGEN die Entwicklung von ... Genpanels, für Blutkrebs  Neuer Test ... Patienten mit Knochenmarkserkrankungen (myelodysplastischen Syndromen) einen günstigen ...
(Date:7/24/2014)... July 24, 2014  Uroplasty, Inc. (NASDAQ: ... manufactures and markets innovative proprietary products to treat ... fiscal 2015 first quarter ended June 30, 2014.  ...  PC Neuromodulation System grew 19% to $4.1 million, ... quarter of the prior year.  Total revenue for ...
(Date:7/24/2014)... July 24, 2014  Mettler-Toledo International Inc. (NYSE: ... 2014.  Provided below are the highlights: , ... quarter compared with the prior year. Reported sales increased ... , Net earnings per diluted share as reported (EPS) ... of 2013. Adjusted EPS was $2.57, an increase of ...
Breaking Medicine Technology:QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 2QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 3QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 4QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 5Uroplasty Reports Fiscal First Quarter Results 2Uroplasty Reports Fiscal First Quarter Results 3Uroplasty Reports Fiscal First Quarter Results 4Uroplasty Reports Fiscal First Quarter Results 5Uroplasty Reports Fiscal First Quarter Results 6Uroplasty Reports Fiscal First Quarter Results 7Uroplasty Reports Fiscal First Quarter Results 8Uroplasty Reports Fiscal First Quarter Results 9Uroplasty Reports Fiscal First Quarter Results 10Uroplasty Reports Fiscal First Quarter Results 11Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 14
... , SAN DIEGO , Feb. 3 ... BDX ), today announced the launch of the ... prevention of influenza. Recognizing that schools and hospitals are important centers ... is designed to communicate that everyone can help prevent the spread ...
... , ATLANTA , Feb. 3 ... of Vytex® Natural Rubber Latex (NRL), a patented, all-natural ... natural rubber latex, has engaged The Investor Relations Group ... New York City , to serve as its ...
Cached Medicine Technology:BD Launches 'Be a Flu Fighter' Campaign to Promote Influenza Awareness and Prevention in Schools, Hospitals and Laboratories 2Vystar Corporation Engages The Investor Relations Group 2Vystar Corporation Engages The Investor Relations Group 3
... RayShield X-Drape combines full 0.25 ... Soft Fiber sterile drape material that ... sterile field between the clinician and ... when the clinician must be in ...
... The first mobile clinical assistant that ... convergence of technologies in the C5 ... normally do during your,shift such as ... take pictures using one single device.,With ...
Patent Pending lateral flow assay platform that contributes to increased sensitivty...
Colloidal Gold Conjugated, Rabbit anti-goat IgG (H&L) - 50 OD...
Medicine Products: