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Study shows 1 in 5 women with ovarian cancer has inherited predisposition
Date:1/22/2014

d in DNA repair and have been linked to certain cancers, including breast and ovarian tumors.

Surprisingly, the researchers found that 37 percent of women with ovarian cancer had either inherited or acquired mutations in the Fanconi anemia pathway, a very high number that indicates its significant role in the development of the disease, Ding said. Women with inherited mutations in this pathway also were more likely to be diagnosed with ovarian cancer at a younger age, the research shows.

A lot of cancer genomics has focused either on inherited mutations or on those acquired during a person's lifetime, called somatic mutations. However, research that involves sequencing both tumor and normal samples from the same patients, like in this study, gives scientists the opportunity to integrate genetic data to see how inherited and somatic mutations cooperate to cause cancer.

"We're now able to obtain a fuller picture of the way cancer develops in a particular patient," Ding said. "More studies are needed, but our findings could have important implications for developing better screening strategies for ovarian cancer and improving early detection."


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Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

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Study shows 1 in 5 women with ovarian cancer has inherited predisposition
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