Navigation Links
Study shows 1 in 5 women with ovarian cancer has inherited predisposition
Date:1/22/2014

with ovarian cancer in the study did not have known family histories of breast or ovarian cancer or rare cancer syndromes, all of which can increase the odds of developing ovarian tumors. The women ranged in age from 26 to 89, and 90 percent were Caucasian.

The researchers, including Washington University first authors Krishna Kanchi, Kimberly Johnson, PhD, and Charles Lu, PhD, performed a genetic analysis of each woman's tumor and her own DNA, taken from a skin sample. By comparing the genetic sequences side-by-side, they identified the acquired mutations in individual tumor samples. In addition, by comparing the patients' DNA samples with the DNA of 557 women who did not have ovarian cancer and served as controls, the researchers found inherited mutations.

In all, the scientists identified 222 inherited genetic variants that increase the risk of ovarian cancer. Some occurred in genes already known to be associated with a genetic predisposition to ovarian cancer, such as BRCA1 and BRCA2, while others occurred in genes that have never been linked to the disease.

The inherited mutations identified as part of the study involved major genetic changes where large chunks of the protein-coding sequences were truncated, or shortened, disrupting the function of key proteins such as those that normally keep cell division in check or repair mistakes in DNA. The scientists also are working to develop new experimental approaches to verify or rule out whether other, smaller inherited genetic changes they discovered also are linked to the development of ovarian cancer.

"With more research, we expect to find additional mutations linked to hereditary ovarian cancer," Ding said. "Thus, 20 percent is a conservative estimate."

Twenty percent of women with ovarian cancer in the study had inherited mutations in a critical pathway of genes associated with Fanconi anemia, a rare, hereditary bone marrow disease. Genes in this pathway are involve
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study shows 1 in 5 women with ovarian cancer has inherited predisposition
(Date:9/4/2015)... ... September 04, 2015 , ... Mile High Connects today releases “First and Last ... funding for sidewalks, bike paths, and other vital supports severely limit access to public ... billions of dollars to expand public transit, there’s very little support for safe and ...
(Date:9/4/2015)... ... ... IVF New England, one of the largest and most successful fertility centers ... for women who wish to learn more about their fertility and egg freezing. , ... Elm Street, Manchester, NH from 6PM to 7PM , This hip, casual and informative ...
(Date:9/4/2015)... ... September 04, 2015 , ... Inmar announced today ... meeting of its Product, Quality and Manufacturers, Dietary Supplements and Supply Chain Committees. ... in the consumer goods industry, it can be difficult for companies to navigate, ...
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... Keeping mold ... and around the home is quite common. Mold can grow anywhere - on carpet, ... leaking pipes. Checking for excessive moisture and water in the home is key to ...
(Date:9/4/2015)... ... September 04, 2015 , ... Mike Day, a former Navy SEAL who ... the Ironman World Championships in Kona on October 10th. , Mike is running the ... (TBI) through combat and the cutting-edge treatments that restore their quality of life. ...
Breaking Medicine News(10 mins):Health News:Missed Connections in Metro Denver Transit 2Health News:IVF New England to Host ManchVegas New Hampshire Fertility Happy Hour on October 15, 2015 in Manchester for Women Who Wish to Learn More About Fertility and Egg Freezing 2Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 2Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 3Health News:September is Mold Awareness Month 2Health News:September is Mold Awareness Month 3Health News:September is Mold Awareness Month 4Health News:Navy SEAL Shot 27 Times Competes in Ironman World Championship in Kona to Raise Money for Veteran's Suffering from TBI and PTSD 2
... solid reputation within industry , , HOFFMAN ESTATES, ... Spine, Inc. announced today that it has appointed Todd P. ... Fanning has held senior sales and marketing positions at well ... orthopaedic industries, including Spinal Concepts (now part of Zimmer ...
... EHR/PM System to Help Physicians, Organization Deliver on Its ... DALLAS, June 9 iMedica Corporation ... physician practices, announced today that after more than two ... Organization of the University Medical Center at Princeton ...
... by Miley Cyrus at the 20th Annual A Time For ... Glaser Pediatric AIDS Foundation , , LOS ANGELES, June ... at the 20th annual A Time For Heroes Family Picnic, ... Elizabeth Glaser Pediatric AIDS Foundation. More than 80 of Hollywood,s ...
... Denise Gott Agrees that Everyone Needs Protection for Longer-Lasting ... , KIRKLAND, Wash., June 9 The traditionally conservative ... Congress on health reform, according to one insurance leader, ... Kennedy (D-MA) for his crusading efforts. "He sees more ...
... ... (MARS) has received CE Mark approval for treating patients with peripheral aneurysms. Product rollout ... ... received CE Mark approval for the commercial sale of its Multilayer Aneurysm Repair System. ...
... ... Global will offer a 22% Recession Price Rollback on their 22, Dell Touch Screen Monitor. ... value. , ... June 9, 2009 -- Today,s market is a very discerning. Smaller budgets, less tax revenues ...
Cached Medicine News:Health News:The Physicians' Organization of the University Medical Center at Princeton Chooses iMedica's EHR and Practice Management Solutions 2Health News:The Physicians' Organization of the University Medical Center at Princeton Chooses iMedica's EHR and Practice Management Solutions 3Health News:Celebrities Come Together to Fight Pediatric AIDS 2Health News:Celebrities Come Together to Fight Pediatric AIDS 3Health News:Insurance Leader Praises Senator Kennedy for Promoting Long-Term Care Aid for All Americans as Part of Health Reform 2Health News:Insurance Leader Praises Senator Kennedy for Promoting Long-Term Care Aid for All Americans as Part of Health Reform 3Health News:Insurance Leader Praises Senator Kennedy for Promoting Long-Term Care Aid for All Americans as Part of Health Reform 4Health News:Cardiatis Multilayer Aneurysm Repair System, MARS, Receives CE Mark Approval for Treating Peripheral Aneurysms 2Health News:Tech Global Price Rollback on their 22" Dell Touch Screen Monitor 2
(Date:9/4/2015)... MENLO PARK, Calif. , Sept. 4, 2015 ... and the "Company"), a biopharmaceutical company focused on the ... its financial results for the fiscal year ending June ... highlights and expected near-term milestones. DelMar,s ... and live webcast for investors, analysts and other interested ...
(Date:9/3/2015)... -- Cipla, a global pharmaceutical company which uses technology and ... today announced that its UK arm, Cipla EU has ... InvaGen Pharmaceuticals Inc., and Exelan Pharmaceuticals Inc. The transaction ... $550 million and will be an all cash transaction. ... million for the year ended Dec 2014 and over ...
(Date:9/3/2015)... Report Details What can be expected from ... grow at the fastest rates? Visiongain,s brand new report ... opportunities and prospects there. Our 205-page report ... lucrative areas in the industry and the future market ... at overall world market and regional level. You will ...
Breaking Medicine Technology:DelMar Pharmaceuticals Reports Fiscal 2015 Year-End Financial Results and Provides Corporate Update 2DelMar Pharmaceuticals Reports Fiscal 2015 Year-End Financial Results and Provides Corporate Update 3DelMar Pharmaceuticals Reports Fiscal 2015 Year-End Financial Results and Provides Corporate Update 4DelMar Pharmaceuticals Reports Fiscal 2015 Year-End Financial Results and Provides Corporate Update 5DelMar Pharmaceuticals Reports Fiscal 2015 Year-End Financial Results and Provides Corporate Update 6DelMar Pharmaceuticals Reports Fiscal 2015 Year-End Financial Results and Provides Corporate Update 7DelMar Pharmaceuticals Reports Fiscal 2015 Year-End Financial Results and Provides Corporate Update 8Cipla to acquire 100% of generic businesses in US for $550M 2Cipla to acquire 100% of generic businesses in US for $550M 3Cipla to acquire 100% of generic businesses in US for $550M 4Cipla to acquire 100% of generic businesses in US for $550M 5Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 2Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 3Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 4
... The 5548 is our High Penetration Steered ... ranging from 3 to 8 MHz. ... offering Pure Harmonic Detection with 4 different ... or deeper vessels. The high color and ...
A rigid version of the popular flexible laparoscopic transducer. It has been proven that a rigid "lap transducer has great utility in the OR for being an extra lifting tool inside the abdomen....
Super High Density, multi-frequency "I shaped convex intraoperative transducer. The UST-995-7.5 nestles comfortably between your index and middle fingers so that you can palpate organs while scanning...
Super High Density, multi frequency Side Fire "T intraoperative transducer. A narrower field of view is this transducers benefit for when scanning in smaller abdomens or in tighter spaces....
Medicine Products: