Navigation Links
Study shows 1 in 5 women with ovarian cancer has inherited predisposition
Date:1/22/2014

A new study conservatively estimates that one in five women with ovarian cancer has inherited genetic mutations that increase the risk of the disease, according to research at Washington University School of Medicine in St. Louis.

Most women in the study would have been unaware of a genetic predisposition to ovarian cancer because they didn't have strong family histories that suggested it.

The research, published Jan. 22 in Nature Communications, is the first large-scale analysis of the combined contributions of inherited and acquired mutations in a major cancer type. The inherited mutations by themselves are unlikely to cause ovarian cancer but may conspire with other genetic changes acquired over a woman's lifetime to tip the balance toward cancer, the researchers said.

Earlier studies that have looked at inherited susceptibility to ovarian cancer have focused on women with known family histories of the disease. For the current study, however, the researchers studied 429 women with ovarian cancer that appeared to develop sporadically, meaning the women did not have known family histories of the disease.

"Using advanced genomic analysis, we found that 20 percent of women with ovarian cancer had inherited mutations in a gene pathway known to be important in inherited breast and ovarian cancer. That number seems pretty high," explained senior author Li Ding, PhD, assistant director at The Genome Institute at the School of Medicine and a research member of Siteman Cancer Center. "This tells us that we need to find better ways to screen women for ovarian cancer, even if they don't have family histories of the disease."

Ovarian cancer strikes an estimated 22,000 women annually. Its symptoms are nonspecific and include bloating, pelvic pain and frequently feeling the need to urinate. Most women aren't diagnosed until the cancer has spread, leading to a poor five-year survival rate of 43 percent.

Women
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study shows 1 in 5 women with ovarian cancer has inherited predisposition
(Date:7/12/2014)... (PRWEB) July 12, 2014 For those who ... bodies can readily absorb the nutrients in food. The enzymes ... that are small enough to be absorbed by human bodies. ... a lack of enzymes in regular food is the cause ... product that was started by Michelle DelPresto, a mother of ...
(Date:7/12/2014)... Salt Lake City, Utah (PRWEB) July 12, 2014 ... Five spotlighted two types of startups, with awards being ... UVEF’s new emphasis spotlighted Utah’s outstanding entrepreneur community with ... are proving a sustainable model with incoming revenue. , ... companies from across the state that are under 5 ...
(Date:7/12/2014)... 2014 Restore My Vision Today is ... Pearson, a couple boasting very impressive credentials on the ... Vision Today as a way to help consumers do ... in their respective patients’ treatments . , ... “secret” trove of pertinent information relevant to eye care ...
(Date:7/11/2014)... MagicQuinceaneraDresses.com, the popular online supplier of special occasion gowns, ... dresses . The company’s new items are specially designed ... a large amount of money. They are all available ... company’s online shop has become a one stop platform ... addition to exquisite Quinceanera dresses, it also offers great ...
(Date:7/11/2014)... July 11, 2014 As transvaginal ... against Johnson & Johnson’s Ethicon Inc. unit continue ... notes that the Texas Attorney General’s Office has ... of surgical mesh products used to treat pelvic ... a report from kens5.com, the probe began nearly ...
Breaking Medicine News(10 mins):Health News:New Super Digestive Enzyme, DZ10, Supercharges The Digestion Process 2Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 3Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 4
... Onchocerciasis, river blindness or craw craw is endemic to ... weakening// in affected individuals thus rendering them listless and ... the economy of this area. The disease is caused ... the bite of the black fly, Simulium. ...
... study published by scientists from California University in the ... re-evaluation//. Scientist have discovered that the virus evaded ... intestinal tissue of patients, where it continued to replicate ... showed that the antiretrovirals were working. ...
... iodine dose to cure deadly brain tumors such as ... is used as carriers for radioactive iodine. The first ... was conducted by under Adam N. Mamelak, M.D., a ... About 18 patients participated in the trial and it ...
... patient was discharged for a week after undergoing successful surgery, ... Guoxing, 30, who had not seen his wife and two ... returned home Friday for a week-long visit to his family ... his face is alive and Li has been doing well, ...
... – The accomplishments of Thailand and Cambodia in the ... achieved primarily through the extensive use of condoms.// ... Singapore's Ministry of Health, said "The 100 per cent ... prominent examples of successful prevention efforts." ,In ...
... been the cornerstones of managing type 2 diabetes. But ... ,Now, a new systematic review shows that exercise ... sensitivity to insulin, and decreases blood lipids (fats) while ... 2 diabetes is an increasing problem in Western societies ...
Cached Medicine News:Health News:Onchocerciasis: Presentation And Treatment 2Health News:New Carrier Developed To Deliver Drugs to Gliomas 2Health News:New Carrier Developed To Deliver Drugs to Gliomas 3Health News:Exercise in Itself Improves Blood Glucose Control in Type 2 Diabetes 2Health News:Exercise in Itself Improves Blood Glucose Control in Type 2 Diabetes 3
(Date:7/10/2014)... NEWPORT NEWS, Virginia , 11. ... führender Hersteller von Kameras für die ... Brust (MBI/BSGI), hat heute die CE-Zulassung ... Mit dem CE-Zeichen kann Dilon das ... seinen Vertriebsbereich auf den Großteil der ...
(Date:7/10/2014)... Yesterday, former Congressman Patrick Kennedy ... facility. Rep. Kennedy and Dick Moberg ... research in neurological disease and treatment. ... Garen Staglin , created One Mind, a ... that will radically accelerate the development and implementation ...
(Date:7/10/2014)... 2014   LabStyle Innovations Corp . (OTCQB:DRIO), developer ... the appointment of Professor Richard B. Stone ... of Directors. Prof. Stone brings over ... LabStyle as an entrepreneur, venture capitalist public, company ... expert. He currently serves on the board of ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4
... half of,health care workers get an annual flu shot, ... and the federal Centers for Disease,Control of the need ... is plenty of vaccine available this season, so there ... shot," said Joanne Grossi, deputy,secretary for health promotion and ...
... COGENT Trials To Enroll 4,000 Patients Worldwide, ... announced today it is launching a global Phase ... of its novel combination therapy CGT-2168.,The program, which ... 4,000 patients at hundreds of sites in the ...
Cached Medicine Technology:State, Federal Officials Remind Health Care Workers, Other at-Risk Individuals to Get Annual Flu Shot 2Cogentus to Launch Phase III Program of Novel Combination Product Designed to Reduce Bleeding Side Effect of Antiplatelet Therapy 2
Straight shafts with 0.5 mm teeth and 6 mm tying platform. Wide serrated handle with thumb catch lock and polished finish....
Angled 45 degree shafts 8 mm long with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Straight shafts with 1 x 2 teeth and 6 mm tying platform. Wide serrated handle with polished finish....
Straight shafts with 1 x 2 teeth. Wide serrated handle with polished finish....
Medicine Products: