Navigation Links
Study sheds new light on role of genetic mutations in colon cancer development
Date:6/7/2012

SEATTLE In exploring the genetics of mitochondria the powerhouse of the cell researchers at Fred Hutchinson Cancer Research Center have stumbled upon a finding that challenges previously held beliefs about the role of mutations in cancer development.

For the first time, researchers have found that the number of new mutations are significantly lower in cancers than in normal cells.

"This is completely opposite of what we see in nuclear DNA, which has an increased overall mutation burden in cancer," said cancer geneticist Jason Bielas, Ph.D., whose findings are published in the June 7 issue of PLoS Genetics.

Mutations are changes in the genetic sequence of a cell's genome and can occur as a result of environmental exposure to viruses, radiation and certain chemicals, or due to spontaneous errors during cell division or DNA replication.

Mitochondria, which are primarily responsible for the cell's energy production, are semi-autonomous; similar to the nucleus, they have their own set of DNA, which encodes genes critical for the functioning of the cell. While the role of genomic instability has been well characterized in nuclear DNA, this is the first attempt to determine whether instability in mitochondrial DNA may play a similar role in cancer growth and metastasis.

"We were surprised to find that the frequency of new mutations in mitochondrial DNA from tumor cells is decreased compared to that of normal cells," said Bielas, an assistant member of the Public Health Sciences and Human Biology divisions at the Hutchinson Center. "By extension, this suggests, somewhat counterintuitively, that higher mitcochondrial mutation rates may actually serve as a barrier to cancer development, and drugs that focus directly on increasing mitochondrial DNA damage and mutation might swap cancer's immortality for accelerated aging and tumor-cell death."

For the study, the researchers used using an ultra-sensitive test to detect mutations in mitoch
'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Two-Thirds of Osteo Hip Fractures Occur After 80: U.S. Study
2. Study links teamwork, communication with quality of nursing home care
3. HIV superinfection in Uganda may be more common than previously thought, study finds
4. Many Kids on Medicaid Dont See Dentist: Study
5. Reach2HD, a Phase II study in Huntingtons disease, launched
6. Belly Membrane May Regulate Immune System, Mouse Study Finds
7. Skin Cells Turned Into Brain Cells in Lab Study
8. Head-to-head study in RA shows that abatacept has comparable efficacy to adalimumab
9. Exercise Appears to Ease Nerve-Damage Pain in Rat Study
10. New Medicine Might Fight Drug-Resistant TB, Study Says
11. Exercise Controls Weight in White Girls Better Than in Black Girls: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... August 20, 2014 LunaDress, a popular ... cocktail dresses for ladies, is now providing a discount ... dresses . The company’s cheap white prom outfits are ... backless, and A-line outfits. , There are over ... product category, and the special offer is valid until ...
(Date:8/19/2014)... Los Angeles, CA (PRWEB) August 19, 2014 ... is an online training course designed to provide users ... businesses using proven email marketing techniques and strategies. The ... has created a buzz of excitement throughout the internet ... caught the attention of HonestyFirstReviews.com's Tiffany Hendricks prompting an ...
(Date:8/19/2014)... HealthDay Reporter TUESDAY, Aug. 19, ... infant has long been linked to development of asthma and ... risk may persist into the teen years. The study, ... underscores the dangers of parental smoking, experts say. ... a child,s risk of developing allergic disease even up to ...
(Date:8/19/2014)... Following the completion of a $16 million rooms renovation ... proud to debut the highly anticipated final phase of its ... of all public spaces to match the fresh look and ... dining experience at 1823 Kitchen and Bar and an innovative ... of 1823 Kitchen and Bar, Grand Hyatt Tampa Bay has ...
(Date:8/19/2014)... Program has selected three geriatric social work ... development and mentorship for projects that will improve ... for all older adults. , The 2014 Hartford/VA ... among veterans, transitions from VA nursing facilities back ... older veterans. The Hartford/VA Geriatric Scholars Program provides ...
Breaking Medicine News(10 mins):Health News:Popular Supplier LunaDress Providing an Exclusive Assortment of White Prom Dresses at a Discount of Up to 67% 2Health News:Anik Singal’s “Inbox Blueprint” Review Released By HonestyFirstReviews.com 2Health News:For Kids, Risks of Parental Smoking Persist Long-Term, Study Finds 2Health News:For Kids, Risks of Parental Smoking Persist Long-Term, Study Finds 3Health News:Grand Hyatt Tampa Bay Hotel Unveils the Finishing Touches of Its $20 Million Makeover 2
... Oct. 4 The following is a,statement regarding Microsoft,s ... information online:, It is encouraging that companies like ... health record (PHR) products and systems,that people can use ... companies will follow suit. Having ready access to your ...
... Orr, fired for managing diabetes at work but ... Thursday before House Judiciary,Subcommittee about his experience, ... today reiterated its strong support for the ADA,Restoration ... the landmark,1990 Americans with Disabilities Act. On Thursday, ...
... ACTON, Mass., Oct. 4 Psychemedics Corporation,(AMEX: ... joined the company,as Vice President, Controller. Jennifer ... financial,reporting activities, as well as the financial analysis ... Jennifer will,report directly to the Chairman and CEO. ...
... Connector, provides patients with virtual diabetes health- ... management ... Association today unveiled a new web-based diabetes tool that,makes it ... -- to,share and organize important health information to improve their ...
... BOSTON, Oct. 4 Diet.com has joined ... of the newly launched Microsoft,HealthVault consumer health ... which currently include,Diet.com Calorie/Meal Tracker, Diet.com Weight ... incorporated into HealthVault. The trackers will,enable users ...
... Oct. 4 Genta,Incorporated (Nasdaq: GNTA ) announced ... Raymond P. Warrell, Jr., will provide an,update of corporate ... 10th at 2:15 pm PDT. The conference will be ... The presentation will be webcast and accessible at the ...
Cached Medicine News:Health News:Statement Regarding Microsoft's Announcement of New Services to Help People Store Their Health Information Online 2Health News:American Diabetes Association Urges Congress to Pass ADA Restoration Act, Help End Employment Discrimination Against Americans with Diabetes 2Health News:American Diabetes Association Urges Congress to Pass ADA Restoration Act, Help End Employment Discrimination Against Americans with Diabetes 3Health News:Jennifer Chmieleski Joins Psychemedics Corporation as Top Financial Officer 2Health News:New Diabetes Tool Available on American Diabetes Association Web Site 2Health News:New Diabetes Tool Available on American Diabetes Association Web Site 3Health News:New Diabetes Tool Available on American Diabetes Association Web Site 4Health News:Diet.com Enters Strategic Collaboration To Support Microsoft HealthVault 2Health News:Genta to Present at Bio Investor Forum 2007 Conference 2Health News:Genta to Present at Bio Investor Forum 2007 Conference 3
(Date:8/19/2014)... , Aug. 19, 2014  Stryker Corporation,s Orthopaedics Division, ... Champions Tour, is bringing its message of joint health to ... Jersey this week at The Barclays.  The company,s ... in the Spectator Village near the 17 th fairway ... starting on Thursday, August 21 st .    ...
(Date:8/19/2014)... 19, 2014  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) will ... , Sanofi and Regeneron will host an IR Thematic Conference Call ... September 2, 2014 , Baird 2014 Healthcare Conference ... 2014 , Citi,s 9 th Annual Biotech ... 4, 2014 , Morgan Stanley Global Healthcare Conference ...
(Date:8/19/2014)... ENGLEWOOD, Colo. , Aug. 19, 2014 /PRNewswire/ ... of Ampio Pharmaceuticals, Inc. (NYSE MKT: ... 73 rd Annual Meeting of the American ... of Acute Care Surgery in Philadelphia, ... 10-13, 2014.  The presentation will report results from ...
Breaking Medicine Technology:Stryker, The Official Joint Replacement Products Of The PGA TOUR, Welcomes Golf Fans To Its Home State Of New Jersey For The Barclays 2Stryker, The Official Joint Replacement Products Of The PGA TOUR, Welcomes Golf Fans To Its Home State Of New Jersey For The Barclays 3Stryker, The Official Joint Replacement Products Of The PGA TOUR, Welcomes Golf Fans To Its Home State Of New Jersey For The Barclays 4Stryker, The Official Joint Replacement Products Of The PGA TOUR, Welcomes Golf Fans To Its Home State Of New Jersey For The Barclays 5Luoxis Announces Presentation of Positive Clinical Findings from Five-Year Clinical Study of Traumatic Brain Injury and Oxidation-Reduction Potential at 2014 American Academy of Surgical Trauma Meeting 2Luoxis Announces Presentation of Positive Clinical Findings from Five-Year Clinical Study of Traumatic Brain Injury and Oxidation-Reduction Potential at 2014 American Academy of Surgical Trauma Meeting 3
... Nov. 16, 2011 Hotspur Technologies today announced ... Catheter in the United States and select international ... Hotspur,s innovative GPSCath™ Balloon Dilatation Catheter integrates ... physicians to inject contrast during a procedure without ...
... DIEGO, Nov. 16, 2011 OncoSec Medical Incorporated (OTCBB: ... to treat solid tumor cancers, today announced it has ... to analyze subjects in three OncoSec Phase II ... cutaneous T-cell lymphoma with the goal of identifying biomarkers ...
Cached Medicine Technology:Hotspur Technologies Commences US Launch at Veith/AIM Conference in New York City 2OncoSec and Serametrix Collaborate to Identify Potential Biomarkers to Enhance Skin Cancer Immune Therapies 2OncoSec and Serametrix Collaborate to Identify Potential Biomarkers to Enhance Skin Cancer Immune Therapies 3OncoSec and Serametrix Collaborate to Identify Potential Biomarkers to Enhance Skin Cancer Immune Therapies 4
Open blade speculum designed for both temporal and superior approach ocular surgery. Thumb screw adjusting mechanism. Manufactured in titanium....
Open 11 mm blades. Dull finish. Most popular size or model....
Open 5 mm blades. Dull finish. Most popular size or model....
Closed wire 5 mm blade with a wing tip twist giving the surgeon better on-axis accessibility....
Medicine Products: