Navigation Links
Study sheds light on role of stem cells in children's brain tumor

New research from scientists at Queen Mary, University of London shows how the most common type of children's brain cancer can arise from stem cells.

Scientists know relatively little about medulloblastomas or why some cases respond better to treatments than others.

The new research, published today in Oncogene*, shows that medulloblastomas can grow from a type of brain stem cell and that these cancers are a distinct form of the disease which may require a completely different approach to treatment.

Medulloblastomas account for one in five of all children's brain tumours. They are most common in children between the ages of three and eight but they can also affect young adults.

Silvia Marino, Professor of Neuropathology at Queen Mary, University of London, led the study. She said: "This type of brain tumour can pose a great challenge to doctors. In some children, treatment works well but in others the cancer is aggressive and far harder to treat.

"As scientists we've been trying to understand how these cancers which look the same can behave so differently.

"This study is a major advance for us because it shows for the first time that some of these tumours develop from endogenous stem cells.

"This is important for two reasons. First, it could help us to tell which cancers will respond well to treatment and which will need a more aggressive therapy. Second, this new understanding could help us to find much-needed new drugs for the disease."

Previous research has shown that human brains contain a small number of stem cells called neural stem cells - which enable the brain to repair itself to some degree. Professor Marino and her team studied equivalent cells taken from mouse brains.

They found that two particular genes called Rb and p53, which are already known to play a role in cancer, could malfunction in these cells and allow the cells to grow uncontrollably. They also found that in mice, these cells turned into medulloblastomas.

The researchers then looked more closely at the genetic makeup of these tumours and found a particular pattern which they compared with tumours taken from patients with medulloblastomas. They found that patients whose tumours also had this genetic pattern were those with the worst survival chances.

The researchers believe that their findings are a crucial first step in understanding the most aggressive form of this disease. They can now begin to look for new ways to tackle the disease in a more effective and possibly less toxic way.


Contact: Sian Halkyard
Queen Mary, University of London

Related medicine news :

1. Study explains why light worsens migraine headaches
2. Abraxis Provides Overview Of ABRAXANE Study
3. Study Suggests Way to Mop Up Leukemia Cells
4. Periodic Paralysis Study Reveals Gene Causing Disorder
5. UCLA study shows metformin is safe for patients with advanced heart failure and diabetes mellitus
6. Technology new gateway into treatment for problem alcohol users: Study
7. Few breast cancer surgeons follow quality of care standards, U-M study finds
8. Study shows serious emotional disturbances among children after Katrina
9. Study links restless leg syndrome with erectile dysfunction in older men
10. Study identifies those elderly most at risk for major depression
11. Despite Earlier Doubts, Feinstein Study Shows Fetal Transplants May Benefit Parkinson's Patients Over Age 60
Post Your Comments:
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... safe and convenient way to dispense prescription medications at home, so he invented ... way to monitor and dispense prescription medications. In doing so, it could help ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is a ... X. With ProSidebar: Fasion, video editors can easily add an informative sidebar to ... title opener. Utilize presets featuring self-animating drop zones, lines, bars, and text with ...
(Date:11/27/2015)... , ... November 27, 2015 , ... A simply groundbreaking ... is an interesting show that delves into an array of issues that are presently ... could benefit from open dialogue, this show is changing the subjects consumers focus on, ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and women on ... organizations in the country. They have overseen financial turnarounds, shown commitment to their ... healthcare industry as a whole through their advocacy and professional efforts. , Becker's ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 --> ... to use SyMRI to find optimal contrast weighting of MRI ... metastases, and has signed a research agreement with SyntheticMR in ... hospital. Using SyMRI, it is possible to generate multiple contrast ... after the patient has left, thus making it possible to ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the Global Cell Surface Testing ... Opportunities" report to their offering.  ... the addition of the  "2016 Future ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
Breaking Medicine Technology: